Expression of two DEAD box genes (DDX1 and DDX6) is independent of that of MYCN in human neuroblastoma cell lines

Kiyotaka Akiyama, Yukihiro Akao, Masahiro Yokoyama, Yoshihito Nakagawa, Tohru Noguchi, Kunio Yagi, Yoshisuke Nishi

Research output: Contribution to journalArticle

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Abstract

To examine whether two DEAD box genes, DDX1 and DDX6, would have some roles in the progression of tumors, we investigated the correlation of the expression of these genes with that of MYCN in neuroblastomas either with or without MYCN amplification. The mRNA of MYCN was observed only in the cell lines with amplification of MYCN. The mRNAs of DDX1 and DDX6 were found in all the cell lines examined, but the correlation between the mRNA levels of DDX1 or DDX6 and MYCN was poor. These findings suggest that the expression of neither DEAD box gene is correlated with the gene expression of MYCN.

Original languageEnglish
Pages (from-to)563-568
Number of pages6
JournalBiochemistry and Molecular Biology International
Volume47
Issue number4
Publication statusPublished - 01-04-1999

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Neuroblastoma
Genes
Cells
Cell Line
Messenger RNA
Amplification
Gene Expression
Gene expression
Tumors
Neoplasms

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Genetics

Cite this

Akiyama, Kiyotaka ; Akao, Yukihiro ; Yokoyama, Masahiro ; Nakagawa, Yoshihito ; Noguchi, Tohru ; Yagi, Kunio ; Nishi, Yoshisuke. / Expression of two DEAD box genes (DDX1 and DDX6) is independent of that of MYCN in human neuroblastoma cell lines. In: Biochemistry and Molecular Biology International. 1999 ; Vol. 47, No. 4. pp. 563-568.
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Expression of two DEAD box genes (DDX1 and DDX6) is independent of that of MYCN in human neuroblastoma cell lines. / Akiyama, Kiyotaka; Akao, Yukihiro; Yokoyama, Masahiro; Nakagawa, Yoshihito; Noguchi, Tohru; Yagi, Kunio; Nishi, Yoshisuke.

In: Biochemistry and Molecular Biology International, Vol. 47, No. 4, 01.04.1999, p. 563-568.

Research output: Contribution to journalArticle

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AU - Akiyama, Kiyotaka

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