Expression of two DEAD box genes (DDX1 and DDX6) is independent of that of MYCN in human neuroblastoma cell lines

Kiyotaka Akiyama; Yukihiro Akao; Masahiro Yokoyama; Yoshihito Nakagawa; Tohru Noguchi; Kunio Yagi; Yoshisuke Nishi

Expression of two DEAD box genes (DDX1 and DDX6) is independent of that of MYCN in human neuroblastoma cell lines

Kiyotaka Akiyama, Yukihiro Akao, Masahiro Yokoyama, Yoshihito Nakagawa, Tohru Noguchi, Kunio Yagi, Yoshisuke Nishi

Research output: Contribution to journal › Article › peer-review

Abstract

To examine whether two DEAD box genes, DDX1 and DDX6, would have some roles in the progression of tumors, we investigated the correlation of the expression of these genes with that of MYCN in neuroblastomas either with or without MYCN amplification. The mRNA of MYCN was observed only in the cell lines with amplification of MYCN. The mRNAs of DDX1 and DDX6 were found in all the cell lines examined, but the correlation between the mRNA levels of DDX1 or DDX6 and MYCN was poor. These findings suggest that the expression of neither DEAD box gene is correlated with the gene expression of MYCN.

Original language	English
Pages (from-to)	563-568
Number of pages	6
Journal	Biochemistry and Molecular Biology International
Volume	47
Issue number	4
Publication status	Published - 04-1999
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Genetics

Cite this

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title = "Expression of two DEAD box genes (DDX1 and DDX6) is independent of that of MYCN in human neuroblastoma cell lines",

abstract = "To examine whether two DEAD box genes, DDX1 and DDX6, would have some roles in the progression of tumors, we investigated the correlation of the expression of these genes with that of MYCN in neuroblastomas either with or without MYCN amplification. The mRNA of MYCN was observed only in the cell lines with amplification of MYCN. The mRNAs of DDX1 and DDX6 were found in all the cell lines examined, but the correlation between the mRNA levels of DDX1 or DDX6 and MYCN was poor. These findings suggest that the expression of neither DEAD box gene is correlated with the gene expression of MYCN.",

author = "Kiyotaka Akiyama and Yukihiro Akao and Masahiro Yokoyama and Yoshihito Nakagawa and Tohru Noguchi and Kunio Yagi and Yoshisuke Nishi",

note = "Funding Information: We thank R. F. Geiger, Jr. for design and construction of the BICON instrument that made this work possible. Acknowledgment is made to the donors of The Petroleum Research Fund, administered by the American Chemical Society, for partial support of this research.",

year = "1999",

month = apr,

language = "English",

volume = "47",

pages = "563--568",

journal = "Biochemistry and Molecular Biology International",

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TY - JOUR

T1 - Expression of two DEAD box genes (DDX1 and DDX6) is independent of that of MYCN in human neuroblastoma cell lines

AU - Akiyama, Kiyotaka

AU - Akao, Yukihiro

AU - Yokoyama, Masahiro

AU - Nakagawa, Yoshihito

AU - Noguchi, Tohru

AU - Yagi, Kunio

AU - Nishi, Yoshisuke

N1 - Funding Information: We thank R. F. Geiger, Jr. for design and construction of the BICON instrument that made this work possible. Acknowledgment is made to the donors of The Petroleum Research Fund, administered by the American Chemical Society, for partial support of this research.

PY - 1999/4

Y1 - 1999/4

N2 - To examine whether two DEAD box genes, DDX1 and DDX6, would have some roles in the progression of tumors, we investigated the correlation of the expression of these genes with that of MYCN in neuroblastomas either with or without MYCN amplification. The mRNA of MYCN was observed only in the cell lines with amplification of MYCN. The mRNAs of DDX1 and DDX6 were found in all the cell lines examined, but the correlation between the mRNA levels of DDX1 or DDX6 and MYCN was poor. These findings suggest that the expression of neither DEAD box gene is correlated with the gene expression of MYCN.

AB - To examine whether two DEAD box genes, DDX1 and DDX6, would have some roles in the progression of tumors, we investigated the correlation of the expression of these genes with that of MYCN in neuroblastomas either with or without MYCN amplification. The mRNA of MYCN was observed only in the cell lines with amplification of MYCN. The mRNAs of DDX1 and DDX6 were found in all the cell lines examined, but the correlation between the mRNA levels of DDX1 or DDX6 and MYCN was poor. These findings suggest that the expression of neither DEAD box gene is correlated with the gene expression of MYCN.

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JO - Biochemistry and Molecular Biology International

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ER -

Expression of two DEAD box genes (DDX1 and DDX6) is independent of that of MYCN in human neuroblastoma cell lines

Abstract

All Science Journal Classification (ASJC) codes

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