Expression of vascular endothelial growth factor-C and vascular endothelial growth factor receptor-3 in esophageal squamous cell carcinoma

Itaru Omoto, Masataka Matsumoto, Hiroshi Okumura, Yasuto Uchikado, Tetsuro Setoyama, Yoshiaki Kita, Tetsuhiro Owaki, Yuko Kijima, Hiroyuki Shinchi, Sumiya Ishigami, Shinichi Ueno, Shoji Natsugoe

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19 Citations (Scopus)

Abstract

Lymph node metastasis is one of the most important prognostic factors in esophageal squamous cell carcinoma (ESCC). Vascular endothelial growth factor (VEGF)-C and its receptor, VEGF receptor-3 (VEGFR-3), are key in the process of lymphangiogenesis. The present study immunohistochemically examined the expression of VEGF-C, VEGFR-3 and D2-40 in 119 patients with ESCC, and microlymphatic vessel density (MLVD) was calculated based on D2-40 expression counts. Positive expression of VEGF-C was found to correlate significantly with depth of tumor invasion, lymphatic invasion and lymph node metastasis (P<0.001, P<0.0001 and P<0.0001, respectively). Patients with deeper tumor invasion showed higher positivity of VEGFR-3 expression (P<0.05), while patients with lymph node metastasis showed higher MLVD (P<0.05). When patients were divided into three groups according to the expression of VEGF-C and VEGFR-3, patients with coexpression of VEGF-C and VEGFR-3 exhibited poorer prognosis and higher MLVD. The VEGF-C/VEGFR-3 axis is important in tumor lymphangiogenesis.

Original languageEnglish
Pages (from-to)1027-1032
Number of pages6
JournalOncology Letters
Volume7
Issue number4
DOIs
Publication statusPublished - 04-2014

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Omoto, I., Matsumoto, M., Okumura, H., Uchikado, Y., Setoyama, T., Kita, Y., Owaki, T., Kijima, Y., Shinchi, H., Ishigami, S., Ueno, S., & Natsugoe, S. (2014). Expression of vascular endothelial growth factor-C and vascular endothelial growth factor receptor-3 in esophageal squamous cell carcinoma. Oncology Letters, 7(4), 1027-1032. https://doi.org/10.3892/ol.2014.1823