Extranodal NK/T-cell lymphoma, nasal type accompanied by PR3-ANCA-associated glomerulonephritis

Yuta Tamoto, Ryo Ishida, Kazuya Shiogama, Hiroshi Kado, Michitsugu Kamezaki, Yoshiaki Chinen, Yosuke Matsumoto, Tetsuro Kusaba, Eiichi Konishi, Yutaka Tsutsumi, Keiichi Tamagaki

Research output: Contribution to journalArticle

Abstract

A 62-year-old man exhibiting nasal obstruction and glomerulonephritis with proteinase 3-antineutrophil cytoplasmic antibodies (PR3-ANCAs) was diagnosed with extranodal NK/T-cell lymphoma, nasal type (ENKL) with infiltration of neutrophils with apoptosis. Chemoradiotherapy reduced the tumor, improved the renal function, and decreased the PR3-ANCA levels. ANCA-positivity is observed in immunoinsufficient diseases, in which neutrophils lead to apoptosis and translocate intracellular granules, such as PR3, to the cell surface, triggering the production of ANCAs. In our case, the PR3-ANCA production was derived from the expression of PR3 on the cell surface of apoptotic neutrophils. This is the first report on ENKL describing the mechanism of ANCA development.

Original languageEnglish
Pages (from-to)2007-2012
Number of pages6
JournalInternal Medicine
Volume56
Issue number15
DOIs
Publication statusPublished - 01-01-2017

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Extranodal NK-T-Cell Lymphoma
Myeloblastin
Antineutrophil Cytoplasmic Antibodies
Glomerulonephritis
Neutrophils
Apoptosis
Nasal Obstruction
Neutrophil Infiltration
Chemoradiotherapy
Antibody Formation
Kidney

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Tamoto, Yuta ; Ishida, Ryo ; Shiogama, Kazuya ; Kado, Hiroshi ; Kamezaki, Michitsugu ; Chinen, Yoshiaki ; Matsumoto, Yosuke ; Kusaba, Tetsuro ; Konishi, Eiichi ; Tsutsumi, Yutaka ; Tamagaki, Keiichi. / Extranodal NK/T-cell lymphoma, nasal type accompanied by PR3-ANCA-associated glomerulonephritis. In: Internal Medicine. 2017 ; Vol. 56, No. 15. pp. 2007-2012.
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abstract = "A 62-year-old man exhibiting nasal obstruction and glomerulonephritis with proteinase 3-antineutrophil cytoplasmic antibodies (PR3-ANCAs) was diagnosed with extranodal NK/T-cell lymphoma, nasal type (ENKL) with infiltration of neutrophils with apoptosis. Chemoradiotherapy reduced the tumor, improved the renal function, and decreased the PR3-ANCA levels. ANCA-positivity is observed in immunoinsufficient diseases, in which neutrophils lead to apoptosis and translocate intracellular granules, such as PR3, to the cell surface, triggering the production of ANCAs. In our case, the PR3-ANCA production was derived from the expression of PR3 on the cell surface of apoptotic neutrophils. This is the first report on ENKL describing the mechanism of ANCA development.",
author = "Yuta Tamoto and Ryo Ishida and Kazuya Shiogama and Hiroshi Kado and Michitsugu Kamezaki and Yoshiaki Chinen and Yosuke Matsumoto and Tetsuro Kusaba and Eiichi Konishi and Yutaka Tsutsumi and Keiichi Tamagaki",
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Tamoto, Y, Ishida, R, Shiogama, K, Kado, H, Kamezaki, M, Chinen, Y, Matsumoto, Y, Kusaba, T, Konishi, E, Tsutsumi, Y & Tamagaki, K 2017, 'Extranodal NK/T-cell lymphoma, nasal type accompanied by PR3-ANCA-associated glomerulonephritis', Internal Medicine, vol. 56, no. 15, pp. 2007-2012. https://doi.org/10.2169/internalmedicine.56.8365

Extranodal NK/T-cell lymphoma, nasal type accompanied by PR3-ANCA-associated glomerulonephritis. / Tamoto, Yuta; Ishida, Ryo; Shiogama, Kazuya; Kado, Hiroshi; Kamezaki, Michitsugu; Chinen, Yoshiaki; Matsumoto, Yosuke; Kusaba, Tetsuro; Konishi, Eiichi; Tsutsumi, Yutaka; Tamagaki, Keiichi.

In: Internal Medicine, Vol. 56, No. 15, 01.01.2017, p. 2007-2012.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Extranodal NK/T-cell lymphoma, nasal type accompanied by PR3-ANCA-associated glomerulonephritis

AU - Tamoto, Yuta

AU - Ishida, Ryo

AU - Shiogama, Kazuya

AU - Kado, Hiroshi

AU - Kamezaki, Michitsugu

AU - Chinen, Yoshiaki

AU - Matsumoto, Yosuke

AU - Kusaba, Tetsuro

AU - Konishi, Eiichi

AU - Tsutsumi, Yutaka

AU - Tamagaki, Keiichi

PY - 2017/1/1

Y1 - 2017/1/1

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AB - A 62-year-old man exhibiting nasal obstruction and glomerulonephritis with proteinase 3-antineutrophil cytoplasmic antibodies (PR3-ANCAs) was diagnosed with extranodal NK/T-cell lymphoma, nasal type (ENKL) with infiltration of neutrophils with apoptosis. Chemoradiotherapy reduced the tumor, improved the renal function, and decreased the PR3-ANCA levels. ANCA-positivity is observed in immunoinsufficient diseases, in which neutrophils lead to apoptosis and translocate intracellular granules, such as PR3, to the cell surface, triggering the production of ANCAs. In our case, the PR3-ANCA production was derived from the expression of PR3 on the cell surface of apoptotic neutrophils. This is the first report on ENKL describing the mechanism of ANCA development.

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