Extravasation of pegylated-liposomal doxorubicin: Favorable outcome after immediate subcutaneous administration of corticosteroids

Ayako Mitsuma; Masataka Sawaki; Takashi Shibata; Sachi Morita; Megumi Inada; Tomoya Shimokata; Mihoko Sugishita; Koichi Kitagawa; Masaki Sawada; Akihiro Nawa; Yuichi Ando

Extravasation of pegylated-liposomal doxorubicin: Favorable outcome after immediate subcutaneous administration of corticosteroids

Ayako Mitsuma, Masataka Sawaki, Takashi Shibata, Sachi Morita, Megumi Inada, Tomoya Shimokata, Mihoko Sugishita, Koichi Kitagawa, Masaki Sawada, Akihiro Nawa, Yuichi Ando

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

A massive extravasation of pegylated-liposomal doxorubicin (Doxil®) accidentally occurred, affecting the right forearm of a 54-year-old woman with metastatic ovarian cancer who was receiving an intravenous infusion of the drug. In accordance with the institutional guidelines for vesicant drugs, a corticosteroid preparation was immediately injected subcutaneously into the surrounding tissues. Clobetasol propionate and an ice pack were then topically applied to the affected region. There were no serious complications at the extravasation site, such as tissue necrosis or severe pain, and only a transient erythema of the skin and desquamation remained after 2 months.

Original language	English
Pages (from-to)	189-192
Number of pages	4
Journal	Nagoya journal of medical science
Volume	74
Issue number	1-2
Publication status	Published - 2012
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@article{7c90784a63d44a16a6af6b6ddf3f8cb1,

title = "Extravasation of pegylated-liposomal doxorubicin: Favorable outcome after immediate subcutaneous administration of corticosteroids",

abstract = "A massive extravasation of pegylated-liposomal doxorubicin (Doxil{\textregistered}) accidentally occurred, affecting the right forearm of a 54-year-old woman with metastatic ovarian cancer who was receiving an intravenous infusion of the drug. In accordance with the institutional guidelines for vesicant drugs, a corticosteroid preparation was immediately injected subcutaneously into the surrounding tissues. Clobetasol propionate and an ice pack were then topically applied to the affected region. There were no serious complications at the extravasation site, such as tissue necrosis or severe pain, and only a transient erythema of the skin and desquamation remained after 2 months.",

keywords = "Chemotherapy, Extravasation, Liposomal doxorubicin, Ovarian cancer",

author = "Ayako Mitsuma and Masataka Sawaki and Takashi Shibata and Sachi Morita and Megumi Inada and Tomoya Shimokata and Mihoko Sugishita and Koichi Kitagawa and Masaki Sawada and Akihiro Nawa and Yuichi Ando",

year = "2012",

language = "English",

volume = "74",

pages = "189--192",

journal = "Nagoya journal of medical science",

issn = "0027-7622",

publisher = "Nagoya University",

number = "1-2",

}

TY - JOUR

T1 - Extravasation of pegylated-liposomal doxorubicin

T2 - Favorable outcome after immediate subcutaneous administration of corticosteroids

AU - Mitsuma, Ayako

AU - Sawaki, Masataka

AU - Shibata, Takashi

AU - Morita, Sachi

AU - Inada, Megumi

AU - Shimokata, Tomoya

AU - Sugishita, Mihoko

AU - Kitagawa, Koichi

AU - Sawada, Masaki

AU - Nawa, Akihiro

AU - Ando, Yuichi

PY - 2012

Y1 - 2012

N2 - A massive extravasation of pegylated-liposomal doxorubicin (Doxil®) accidentally occurred, affecting the right forearm of a 54-year-old woman with metastatic ovarian cancer who was receiving an intravenous infusion of the drug. In accordance with the institutional guidelines for vesicant drugs, a corticosteroid preparation was immediately injected subcutaneously into the surrounding tissues. Clobetasol propionate and an ice pack were then topically applied to the affected region. There were no serious complications at the extravasation site, such as tissue necrosis or severe pain, and only a transient erythema of the skin and desquamation remained after 2 months.

AB - A massive extravasation of pegylated-liposomal doxorubicin (Doxil®) accidentally occurred, affecting the right forearm of a 54-year-old woman with metastatic ovarian cancer who was receiving an intravenous infusion of the drug. In accordance with the institutional guidelines for vesicant drugs, a corticosteroid preparation was immediately injected subcutaneously into the surrounding tissues. Clobetasol propionate and an ice pack were then topically applied to the affected region. There were no serious complications at the extravasation site, such as tissue necrosis or severe pain, and only a transient erythema of the skin and desquamation remained after 2 months.

KW - Chemotherapy

KW - Extravasation

KW - Liposomal doxorubicin

KW - Ovarian cancer

UR - https://www.scopus.com/pages/publications/84860604257

UR - https://www.scopus.com/inward/citedby.url?scp=84860604257&partnerID=8YFLogxK

M3 - Article

C2 - 22515126

AN - SCOPUS:84860604257

SN - 0027-7622

VL - 74

SP - 189

EP - 192

JO - Nagoya journal of medical science

JF - Nagoya journal of medical science

IS - 1-2

ER -

Extravasation of pegylated-liposomal doxorubicin: Favorable outcome after immediate subcutaneous administration of corticosteroids

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

Other files and links

Fingerprint

Cite this