Extremely preterm infants small for gestational age are at risk for motor impairment at 3years corrected age

Takeshi Kato, Tsurue Mandai, Sota Iwatani, Tsubasa Koda, Miwako Nagasaka, Kaori Fujita, Daisuke Kurokawa, Keiji Yamana, Kosuke Nishida, Mariko Ikeda, Kenji Tanimura, Masashi Deguchi, Hideto Yamada, Kazumoto Iijima, Ichiro Morioka

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Few studies have targeted psychomotor development and associated perinatal risk factors in Japanese very low birth weight (VLBW) infants who are severely small for gestational age (SGA). Design/subjects: A single-center study was conducted in 104 Japanese VLBW infants who were born preterm, due to maternal, umbilical cord, or placental abnormalities, between 2000 and 2007. Psychomotor development as a developmental quotient (DQ) was assessed using the Kyoto Scale of Psychological Development at 3. years corrected age. Severely SGA was defined as birth weight or length below -2 standard deviation values of the mean values at the same gestation. VLBW infants were divided into 2 subgroups based on gestational age at birth: ≥28. weeks (n= 64) and <28. weeks (n= 40). DQs of infants with severe SGA were compared with those of infants who were appropriate for gestational age (AGA). Factors associated with developmental disabilities in VLBW infants with severe SGA (n= 23) were determined. Results: In the group born at ≥28. weeks gestation, infants with severe SGA had normal DQ values and did not significantly differ from those with AGA. However, in the group born at <28. weeks gestation, severe SGA infants had significantly lower postural-motor DQ values than AGA infants. Gestational age <28. weeks was an independent factor for low postural-motor DQ, regardless of the cause of severe SGA or pregnancy termination. Conclusions: Extremely preterm newborns with severe SGA are at risk of motor developmental disability at age 3 years.

Original languageEnglish
Pages (from-to)188-195
Number of pages8
JournalBrain and Development
Volume38
Issue number2
DOIs
Publication statusPublished - 01-02-2016

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Extremely Premature Infants
Gestational Age
Very Low Birth Weight Infant
Pregnancy
Developmental Disabilities
Small for Gestational Age Infant
Umbilical Cord
Birth Weight

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Clinical Neurology

Cite this

Kato, Takeshi ; Mandai, Tsurue ; Iwatani, Sota ; Koda, Tsubasa ; Nagasaka, Miwako ; Fujita, Kaori ; Kurokawa, Daisuke ; Yamana, Keiji ; Nishida, Kosuke ; Ikeda, Mariko ; Tanimura, Kenji ; Deguchi, Masashi ; Yamada, Hideto ; Iijima, Kazumoto ; Morioka, Ichiro. / Extremely preterm infants small for gestational age are at risk for motor impairment at 3years corrected age. In: Brain and Development. 2016 ; Vol. 38, No. 2. pp. 188-195.
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abstract = "Background: Few studies have targeted psychomotor development and associated perinatal risk factors in Japanese very low birth weight (VLBW) infants who are severely small for gestational age (SGA). Design/subjects: A single-center study was conducted in 104 Japanese VLBW infants who were born preterm, due to maternal, umbilical cord, or placental abnormalities, between 2000 and 2007. Psychomotor development as a developmental quotient (DQ) was assessed using the Kyoto Scale of Psychological Development at 3. years corrected age. Severely SGA was defined as birth weight or length below -2 standard deviation values of the mean values at the same gestation. VLBW infants were divided into 2 subgroups based on gestational age at birth: ≥28. weeks (n= 64) and <28. weeks (n= 40). DQs of infants with severe SGA were compared with those of infants who were appropriate for gestational age (AGA). Factors associated with developmental disabilities in VLBW infants with severe SGA (n= 23) were determined. Results: In the group born at ≥28. weeks gestation, infants with severe SGA had normal DQ values and did not significantly differ from those with AGA. However, in the group born at <28. weeks gestation, severe SGA infants had significantly lower postural-motor DQ values than AGA infants. Gestational age <28. weeks was an independent factor for low postural-motor DQ, regardless of the cause of severe SGA or pregnancy termination. Conclusions: Extremely preterm newborns with severe SGA are at risk of motor developmental disability at age 3 years.",
author = "Takeshi Kato and Tsurue Mandai and Sota Iwatani and Tsubasa Koda and Miwako Nagasaka and Kaori Fujita and Daisuke Kurokawa and Keiji Yamana and Kosuke Nishida and Mariko Ikeda and Kenji Tanimura and Masashi Deguchi and Hideto Yamada and Kazumoto Iijima and Ichiro Morioka",
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Kato, T, Mandai, T, Iwatani, S, Koda, T, Nagasaka, M, Fujita, K, Kurokawa, D, Yamana, K, Nishida, K, Ikeda, M, Tanimura, K, Deguchi, M, Yamada, H, Iijima, K & Morioka, I 2016, 'Extremely preterm infants small for gestational age are at risk for motor impairment at 3years corrected age', Brain and Development, vol. 38, no. 2, pp. 188-195. https://doi.org/10.1016/j.braindev.2015.07.008

Extremely preterm infants small for gestational age are at risk for motor impairment at 3years corrected age. / Kato, Takeshi; Mandai, Tsurue; Iwatani, Sota; Koda, Tsubasa; Nagasaka, Miwako; Fujita, Kaori; Kurokawa, Daisuke; Yamana, Keiji; Nishida, Kosuke; Ikeda, Mariko; Tanimura, Kenji; Deguchi, Masashi; Yamada, Hideto; Iijima, Kazumoto; Morioka, Ichiro.

In: Brain and Development, Vol. 38, No. 2, 01.02.2016, p. 188-195.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Extremely preterm infants small for gestational age are at risk for motor impairment at 3years corrected age

AU - Kato, Takeshi

AU - Mandai, Tsurue

AU - Iwatani, Sota

AU - Koda, Tsubasa

AU - Nagasaka, Miwako

AU - Fujita, Kaori

AU - Kurokawa, Daisuke

AU - Yamana, Keiji

AU - Nishida, Kosuke

AU - Ikeda, Mariko

AU - Tanimura, Kenji

AU - Deguchi, Masashi

AU - Yamada, Hideto

AU - Iijima, Kazumoto

AU - Morioka, Ichiro

PY - 2016/2/1

Y1 - 2016/2/1

N2 - Background: Few studies have targeted psychomotor development and associated perinatal risk factors in Japanese very low birth weight (VLBW) infants who are severely small for gestational age (SGA). Design/subjects: A single-center study was conducted in 104 Japanese VLBW infants who were born preterm, due to maternal, umbilical cord, or placental abnormalities, between 2000 and 2007. Psychomotor development as a developmental quotient (DQ) was assessed using the Kyoto Scale of Psychological Development at 3. years corrected age. Severely SGA was defined as birth weight or length below -2 standard deviation values of the mean values at the same gestation. VLBW infants were divided into 2 subgroups based on gestational age at birth: ≥28. weeks (n= 64) and <28. weeks (n= 40). DQs of infants with severe SGA were compared with those of infants who were appropriate for gestational age (AGA). Factors associated with developmental disabilities in VLBW infants with severe SGA (n= 23) were determined. Results: In the group born at ≥28. weeks gestation, infants with severe SGA had normal DQ values and did not significantly differ from those with AGA. However, in the group born at <28. weeks gestation, severe SGA infants had significantly lower postural-motor DQ values than AGA infants. Gestational age <28. weeks was an independent factor for low postural-motor DQ, regardless of the cause of severe SGA or pregnancy termination. Conclusions: Extremely preterm newborns with severe SGA are at risk of motor developmental disability at age 3 years.

AB - Background: Few studies have targeted psychomotor development and associated perinatal risk factors in Japanese very low birth weight (VLBW) infants who are severely small for gestational age (SGA). Design/subjects: A single-center study was conducted in 104 Japanese VLBW infants who were born preterm, due to maternal, umbilical cord, or placental abnormalities, between 2000 and 2007. Psychomotor development as a developmental quotient (DQ) was assessed using the Kyoto Scale of Psychological Development at 3. years corrected age. Severely SGA was defined as birth weight or length below -2 standard deviation values of the mean values at the same gestation. VLBW infants were divided into 2 subgroups based on gestational age at birth: ≥28. weeks (n= 64) and <28. weeks (n= 40). DQs of infants with severe SGA were compared with those of infants who were appropriate for gestational age (AGA). Factors associated with developmental disabilities in VLBW infants with severe SGA (n= 23) were determined. Results: In the group born at ≥28. weeks gestation, infants with severe SGA had normal DQ values and did not significantly differ from those with AGA. However, in the group born at <28. weeks gestation, severe SGA infants had significantly lower postural-motor DQ values than AGA infants. Gestational age <28. weeks was an independent factor for low postural-motor DQ, regardless of the cause of severe SGA or pregnancy termination. Conclusions: Extremely preterm newborns with severe SGA are at risk of motor developmental disability at age 3 years.

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