TY - JOUR
T1 - Extremely preterm infants small for gestational age are at risk for motor impairment at 3years corrected age
AU - Kato, Takeshi
AU - Mandai, Tsurue
AU - Iwatani, Sota
AU - Koda, Tsubasa
AU - Nagasaka, Miwako
AU - Fujita, Kaori
AU - Kurokawa, Daisuke
AU - Yamana, Keiji
AU - Nishida, Kosuke
AU - Taniguchi-Ikeda, Mariko
AU - Tanimura, Kenji
AU - Deguchi, Masashi
AU - Yamada, Hideto
AU - Iijima, Kazumoto
AU - Morioka, Ichiro
N1 - Publisher Copyright:
© 2015 The Japanese Society of Child Neurology.
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Background: Few studies have targeted psychomotor development and associated perinatal risk factors in Japanese very low birth weight (VLBW) infants who are severely small for gestational age (SGA). Design/subjects: A single-center study was conducted in 104 Japanese VLBW infants who were born preterm, due to maternal, umbilical cord, or placental abnormalities, between 2000 and 2007. Psychomotor development as a developmental quotient (DQ) was assessed using the Kyoto Scale of Psychological Development at 3. years corrected age. Severely SGA was defined as birth weight or length below -2 standard deviation values of the mean values at the same gestation. VLBW infants were divided into 2 subgroups based on gestational age at birth: ≥28. weeks (n= 64) and <28. weeks (n= 40). DQs of infants with severe SGA were compared with those of infants who were appropriate for gestational age (AGA). Factors associated with developmental disabilities in VLBW infants with severe SGA (n= 23) were determined. Results: In the group born at ≥28. weeks gestation, infants with severe SGA had normal DQ values and did not significantly differ from those with AGA. However, in the group born at <28. weeks gestation, severe SGA infants had significantly lower postural-motor DQ values than AGA infants. Gestational age <28. weeks was an independent factor for low postural-motor DQ, regardless of the cause of severe SGA or pregnancy termination. Conclusions: Extremely preterm newborns with severe SGA are at risk of motor developmental disability at age 3 years.
AB - Background: Few studies have targeted psychomotor development and associated perinatal risk factors in Japanese very low birth weight (VLBW) infants who are severely small for gestational age (SGA). Design/subjects: A single-center study was conducted in 104 Japanese VLBW infants who were born preterm, due to maternal, umbilical cord, or placental abnormalities, between 2000 and 2007. Psychomotor development as a developmental quotient (DQ) was assessed using the Kyoto Scale of Psychological Development at 3. years corrected age. Severely SGA was defined as birth weight or length below -2 standard deviation values of the mean values at the same gestation. VLBW infants were divided into 2 subgroups based on gestational age at birth: ≥28. weeks (n= 64) and <28. weeks (n= 40). DQs of infants with severe SGA were compared with those of infants who were appropriate for gestational age (AGA). Factors associated with developmental disabilities in VLBW infants with severe SGA (n= 23) were determined. Results: In the group born at ≥28. weeks gestation, infants with severe SGA had normal DQ values and did not significantly differ from those with AGA. However, in the group born at <28. weeks gestation, severe SGA infants had significantly lower postural-motor DQ values than AGA infants. Gestational age <28. weeks was an independent factor for low postural-motor DQ, regardless of the cause of severe SGA or pregnancy termination. Conclusions: Extremely preterm newborns with severe SGA are at risk of motor developmental disability at age 3 years.
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U2 - 10.1016/j.braindev.2015.07.008
DO - 10.1016/j.braindev.2015.07.008
M3 - Article
C2 - 26265090
AN - SCOPUS:84951570415
SN - 0387-7604
VL - 38
SP - 188
EP - 195
JO - Brain and Development
JF - Brain and Development
IS - 2
ER -