Eyes open on stem cells

Anna Altshuler; Aya Amitai-Lange; Waseem Nasser; Shalini Dimri; Swarnabh Bhattacharya; Beatrice Tiosano; Ramez Barbara; Daniel Aberdam; Shigeto Shimmura; Ruby Shalom-Feuerstein

doi:10.1016/j.stemcr.2023.10.023

Eyes open on stem cells

Anna Altshuler, Aya Amitai-Lange, Waseem Nasser, Shalini Dimri, Swarnabh Bhattacharya, Beatrice Tiosano, Ramez Barbara, Daniel Aberdam, Shigeto Shimmura, Ruby Shalom-Feuerstein

Research output: Contribution to journal › Review article › peer-review

2 Citations (Scopus)

Abstract

Recently, the murine cornea has reemerged as a robust stem cell (SC) model, allowing individual SC tracing in living animals. The cornea has pioneered seminal discoveries in SC biology and regenerative medicine, from the first corneal transplantation in 1905 to the identification of limbal SCs and their transplantation to successfully restore vision in the early 1990s. Recent experiments have exposed unexpected properties attributed to SCs and progenitors and revealed flexibility in the differentiation program and a key role for the SC niche. Here, we discuss the limbal SC model and its broader relevance to other tissues, disease, and therapy.

Original language	English
Pages (from-to)	2313-2327
Number of pages	15
Journal	Stem Cell Reports
Volume	18
Issue number	12
DOIs	https://doi.org/10.1016/j.stemcr.2023.10.023
Publication status	Published - 12-12-2023
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Genetics
Developmental Biology
Cell Biology

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10.1016/j.stemcr.2023.10.023

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title = "Eyes open on stem cells",

abstract = "Recently, the murine cornea has reemerged as a robust stem cell (SC) model, allowing individual SC tracing in living animals. The cornea has pioneered seminal discoveries in SC biology and regenerative medicine, from the first corneal transplantation in 1905 to the identification of limbal SCs and their transplantation to successfully restore vision in the early 1990s. Recent experiments have exposed unexpected properties attributed to SCs and progenitors and revealed flexibility in the differentiation program and a key role for the SC niche. Here, we discuss the limbal SC model and its broader relevance to other tissues, disease, and therapy.",

author = "Anna Altshuler and Aya Amitai-Lange and Waseem Nasser and Shalini Dimri and Swarnabh Bhattacharya and Beatrice Tiosano and Ramez Barbara and Daniel Aberdam and Shigeto Shimmura and Ruby Shalom-Feuerstein",

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doi = "10.1016/j.stemcr.2023.10.023",

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T1 - Eyes open on stem cells

AU - Altshuler, Anna

AU - Amitai-Lange, Aya

AU - Nasser, Waseem

AU - Dimri, Shalini

AU - Bhattacharya, Swarnabh

AU - Tiosano, Beatrice

AU - Barbara, Ramez

AU - Aberdam, Daniel

AU - Shimmura, Shigeto

AU - Shalom-Feuerstein, Ruby

PY - 2023/12/12

Y1 - 2023/12/12

N2 - Recently, the murine cornea has reemerged as a robust stem cell (SC) model, allowing individual SC tracing in living animals. The cornea has pioneered seminal discoveries in SC biology and regenerative medicine, from the first corneal transplantation in 1905 to the identification of limbal SCs and their transplantation to successfully restore vision in the early 1990s. Recent experiments have exposed unexpected properties attributed to SCs and progenitors and revealed flexibility in the differentiation program and a key role for the SC niche. Here, we discuss the limbal SC model and its broader relevance to other tissues, disease, and therapy.

AB - Recently, the murine cornea has reemerged as a robust stem cell (SC) model, allowing individual SC tracing in living animals. The cornea has pioneered seminal discoveries in SC biology and regenerative medicine, from the first corneal transplantation in 1905 to the identification of limbal SCs and their transplantation to successfully restore vision in the early 1990s. Recent experiments have exposed unexpected properties attributed to SCs and progenitors and revealed flexibility in the differentiation program and a key role for the SC niche. Here, we discuss the limbal SC model and its broader relevance to other tissues, disease, and therapy.

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DO - 10.1016/j.stemcr.2023.10.023

M3 - Review article

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AN - SCOPUS:85179004993

SN - 2213-6711

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SP - 2313

EP - 2327

JO - Stem Cell Reports

JF - Stem Cell Reports

IS - 12

ER -

Eyes open on stem cells

Abstract

All Science Journal Classification (ASJC) codes

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