Fabrication of ZnPc/protein nanohorns for double photodynamic and hyperthermic cancer phototherapy

Minfang Zhang, Tatsuya Murakami, Kumiko Ajima, Kunihiro Tsuchida, Atula S.D. Sandanayaka, Osamu Ito, Sumio Iijima, Masako Yudasaka

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216 Citations (Scopus)

Abstract

Multifunctionalization of carbon nanotubules is easily achieved by attaching functional molecules that provide specific advantages for microscopic applications. We fabricated a double photodynamic therapy (PDT) and photohyperthermia (PHT) cancer phototherapy system that uses a single laser. Zinc phthalocyanine (ZnPc) was loaded onto single-wall carbon nanohorns with holes opened (SWNHox), and the protein bovine serum albumin (BSA) was attached to the carboxyl groups of SWNHox. In this system, ZnPc was the PDT agent, SWNHox was the PHT agent, and BSA enhanced biocompatibility. The double phototherapy effect was confirmed in vitro and in vivo. When ZnPc-SWNHox-BSA was injected into tumors that were subcutaneously transplanted into mice, the tumors almost disappeared upon 670-nm laser irradiation. In contrast, the tumors continued to grow when only ZnPc or SWNHox-BSA was injected. We conclude that carbon nanotubules may be a valuable new tool for use in cancer phototherapy.

Original languageEnglish
Pages (from-to)14773-14778
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume105
Issue number39
DOIs
Publication statusPublished - 30-09-2008

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All Science Journal Classification (ASJC) codes

  • General

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