Facilitation of long-term potentiation and memory in mice lacking nociceptin receptors

Toshiya Manabe, Yukihiro Noda, Takayoshi Mamiya, Hiroyuki Katagiri, Takeshi Houtani, Miyuki Nishi, Tetsuo Noda, Tomoyuki Takahashi, Tetsuo Sugimoto, Toshitaka Nabeshima, Hiroshi Takeshima

Research output: Contribution to journalArticle

278 Citations (Scopus)

Abstract

The peptide nociceptin (also named orphanin FQ) acts in the brain to produce various pharmacological effects, including hyperalgesia and hypolocomotion. The nociceptin receptor uses guanine-nucleotide-binding proteins to mediate the inhibition of adenylyl cyclase, the activation of potassium channels and inhibition of calcium channels. It has been shown using knockout mice that the nociceptin receptor is not required for regulation of nociceptive responses or locomotion activity, but modulates the auditory function. Here we show that mice lacking the nociceptin receptor possess greater learning ability and have better memory than control mice. Histological analysis revealed the expression of both the nociceptin precursor and the nociceptin receptor in the hippocampus, thought to take part in aspects of learning and memory. Moreover, the receptor-deficient mice showed larger long-term potentiation in the hippocampal CA1 region than control mice, without apparent changes in presynaptic or postsynaptic electrophysiological properties. These results show that the loss of the nociceptin receptor results in a gain-of-function mutation in both the memory process and the long-term potentiation mechanism in CA1, perhaps as a result of altered intracellular signal transduction systems in neurons.

Original languageEnglish
Pages (from-to)577-581
Number of pages5
JournalNature
Volume394
Issue number6693
DOIs
Publication statusPublished - 06-08-1998
Externally publishedYes

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Long-Term Memory
Long-Term Potentiation
Learning
Hippocampal CA1 Region
Aptitude
Guanine Nucleotides
Potassium Channels
Hyperalgesia
Calcium Channels
Locomotion
Adenylyl Cyclases
Knockout Mice
Signal Transduction
Hippocampus
Carrier Proteins
nociceptin receptor
Pharmacology
Neurons
Peptides
Mutation

All Science Journal Classification (ASJC) codes

  • General

Cite this

Manabe, T., Noda, Y., Mamiya, T., Katagiri, H., Houtani, T., Nishi, M., ... Takeshima, H. (1998). Facilitation of long-term potentiation and memory in mice lacking nociceptin receptors. Nature, 394(6693), 577-581. https://doi.org/10.1038/29073
Manabe, Toshiya ; Noda, Yukihiro ; Mamiya, Takayoshi ; Katagiri, Hiroyuki ; Houtani, Takeshi ; Nishi, Miyuki ; Noda, Tetsuo ; Takahashi, Tomoyuki ; Sugimoto, Tetsuo ; Nabeshima, Toshitaka ; Takeshima, Hiroshi. / Facilitation of long-term potentiation and memory in mice lacking nociceptin receptors. In: Nature. 1998 ; Vol. 394, No. 6693. pp. 577-581.
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Manabe, T, Noda, Y, Mamiya, T, Katagiri, H, Houtani, T, Nishi, M, Noda, T, Takahashi, T, Sugimoto, T, Nabeshima, T & Takeshima, H 1998, 'Facilitation of long-term potentiation and memory in mice lacking nociceptin receptors', Nature, vol. 394, no. 6693, pp. 577-581. https://doi.org/10.1038/29073

Facilitation of long-term potentiation and memory in mice lacking nociceptin receptors. / Manabe, Toshiya; Noda, Yukihiro; Mamiya, Takayoshi; Katagiri, Hiroyuki; Houtani, Takeshi; Nishi, Miyuki; Noda, Tetsuo; Takahashi, Tomoyuki; Sugimoto, Tetsuo; Nabeshima, Toshitaka; Takeshima, Hiroshi.

In: Nature, Vol. 394, No. 6693, 06.08.1998, p. 577-581.

Research output: Contribution to journalArticle

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Manabe T, Noda Y, Mamiya T, Katagiri H, Houtani T, Nishi M et al. Facilitation of long-term potentiation and memory in mice lacking nociceptin receptors. Nature. 1998 Aug 6;394(6693):577-581. https://doi.org/10.1038/29073