Factors associated with diagnostic stage of hip osteoarthritis due to acetabular dysplasia among Japanese female patients: A cross-sectional study

Satoko Ohfuji, Seiya Jingushi, Kyoko Kondo, Muroto Sofue, Moritoshi Itoman, Tadami Matsumoto, Yoshiki Hamada, Hiroyuki Shindo, Yoshio Takatori, Harumoto Yamada, Yuji Yasunaga, Hiroshi Ito, Satoshi Mori, Ichiro Owan, Genji Fujii, Hirotsugu Ohashi, Shinji Takahashi, Yoshio Hirota

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Abstract

Background: In Japan, the majority of hip osteoarthritis (OA) was caused by acetabular dysplasia, and about 90 % of patients were female. The present study focused on Japanese female patients with hip OA due to acetabular dysplasia, and examined the associated factors with OA staging at diagnosis, in special reference to body weight. Methods: Study subjects were 336 Japanese women who were newly diagnosed with hip OA caused by acetabular dysplasia at 15 hospitals in 2008. The self-administered questionnaire elicited patients' body weight at age 20 and at OA diagnosis. Four ranked OA staging according to radiographic findings of the hip joint (pre-OA, initial stage, advanced stage or terminal stage) was regarded as the outcome index. Proportional odds models in logistic regression were used to calculate odds ratios (ORs) and 95 % confidence intervals (CIs) for severer stage of OA. Results: At diagnosis, 45 % of patients suffered from terminal stage of OA, whereas 13 % and 14 % were categorized into pre-OA and initial stage, respectively. After adjustment for potential confounders, weight gain since age 20 revealed the increased ORs for severer OA stage at diagnosis (OR 2.02; 95 % CI, 1.07-3.80). Other significant characteristics were age (67+ vs. 20-49 years, OR 12.4), lower education (junior high school vs. junior college or higher, OR 4.00), parity (OR 2.19), lower acetabular head index (<60.0 vs. 71.1+, OR 2.36), and longer duration since symptom onset (6.0+ vs. <1.0 year, OR 2.94). Conclusions: Weight gain since age 20 might be involved in mechanisms of OA development, which is independent of age or severity of acetabular dysplasia.

Original languageEnglish
Article number320
JournalBMC Musculoskeletal Disorders
Volume17
Issue number1
DOIs
Publication statusPublished - 02-08-2016

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Hip Osteoarthritis
Osteoarthritis
Cross-Sectional Studies
Odds Ratio
Weight Gain
Body Weight
Confidence Intervals
Hip Joint
Parity
Japan
Logistic Models
Head
Education

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Orthopedics and Sports Medicine

Cite this

Ohfuji, Satoko ; Jingushi, Seiya ; Kondo, Kyoko ; Sofue, Muroto ; Itoman, Moritoshi ; Matsumoto, Tadami ; Hamada, Yoshiki ; Shindo, Hiroyuki ; Takatori, Yoshio ; Yamada, Harumoto ; Yasunaga, Yuji ; Ito, Hiroshi ; Mori, Satoshi ; Owan, Ichiro ; Fujii, Genji ; Ohashi, Hirotsugu ; Takahashi, Shinji ; Hirota, Yoshio. / Factors associated with diagnostic stage of hip osteoarthritis due to acetabular dysplasia among Japanese female patients : A cross-sectional study. In: BMC Musculoskeletal Disorders. 2016 ; Vol. 17, No. 1.
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title = "Factors associated with diagnostic stage of hip osteoarthritis due to acetabular dysplasia among Japanese female patients: A cross-sectional study",
abstract = "Background: In Japan, the majority of hip osteoarthritis (OA) was caused by acetabular dysplasia, and about 90 {\%} of patients were female. The present study focused on Japanese female patients with hip OA due to acetabular dysplasia, and examined the associated factors with OA staging at diagnosis, in special reference to body weight. Methods: Study subjects were 336 Japanese women who were newly diagnosed with hip OA caused by acetabular dysplasia at 15 hospitals in 2008. The self-administered questionnaire elicited patients' body weight at age 20 and at OA diagnosis. Four ranked OA staging according to radiographic findings of the hip joint (pre-OA, initial stage, advanced stage or terminal stage) was regarded as the outcome index. Proportional odds models in logistic regression were used to calculate odds ratios (ORs) and 95 {\%} confidence intervals (CIs) for severer stage of OA. Results: At diagnosis, 45 {\%} of patients suffered from terminal stage of OA, whereas 13 {\%} and 14 {\%} were categorized into pre-OA and initial stage, respectively. After adjustment for potential confounders, weight gain since age 20 revealed the increased ORs for severer OA stage at diagnosis (OR 2.02; 95 {\%} CI, 1.07-3.80). Other significant characteristics were age (67+ vs. 20-49 years, OR 12.4), lower education (junior high school vs. junior college or higher, OR 4.00), parity (OR 2.19), lower acetabular head index (<60.0 vs. 71.1+, OR 2.36), and longer duration since symptom onset (6.0+ vs. <1.0 year, OR 2.94). Conclusions: Weight gain since age 20 might be involved in mechanisms of OA development, which is independent of age or severity of acetabular dysplasia.",
author = "Satoko Ohfuji and Seiya Jingushi and Kyoko Kondo and Muroto Sofue and Moritoshi Itoman and Tadami Matsumoto and Yoshiki Hamada and Hiroyuki Shindo and Yoshio Takatori and Harumoto Yamada and Yuji Yasunaga and Hiroshi Ito and Satoshi Mori and Ichiro Owan and Genji Fujii and Hirotsugu Ohashi and Shinji Takahashi and Yoshio Hirota",
year = "2016",
month = "8",
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doi = "10.1186/s12891-016-1179-4",
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Ohfuji, S, Jingushi, S, Kondo, K, Sofue, M, Itoman, M, Matsumoto, T, Hamada, Y, Shindo, H, Takatori, Y, Yamada, H, Yasunaga, Y, Ito, H, Mori, S, Owan, I, Fujii, G, Ohashi, H, Takahashi, S & Hirota, Y 2016, 'Factors associated with diagnostic stage of hip osteoarthritis due to acetabular dysplasia among Japanese female patients: A cross-sectional study', BMC Musculoskeletal Disorders, vol. 17, no. 1, 320. https://doi.org/10.1186/s12891-016-1179-4

Factors associated with diagnostic stage of hip osteoarthritis due to acetabular dysplasia among Japanese female patients : A cross-sectional study. / Ohfuji, Satoko; Jingushi, Seiya; Kondo, Kyoko; Sofue, Muroto; Itoman, Moritoshi; Matsumoto, Tadami; Hamada, Yoshiki; Shindo, Hiroyuki; Takatori, Yoshio; Yamada, Harumoto; Yasunaga, Yuji; Ito, Hiroshi; Mori, Satoshi; Owan, Ichiro; Fujii, Genji; Ohashi, Hirotsugu; Takahashi, Shinji; Hirota, Yoshio.

In: BMC Musculoskeletal Disorders, Vol. 17, No. 1, 320, 02.08.2016.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Factors associated with diagnostic stage of hip osteoarthritis due to acetabular dysplasia among Japanese female patients

T2 - A cross-sectional study

AU - Ohfuji, Satoko

AU - Jingushi, Seiya

AU - Kondo, Kyoko

AU - Sofue, Muroto

AU - Itoman, Moritoshi

AU - Matsumoto, Tadami

AU - Hamada, Yoshiki

AU - Shindo, Hiroyuki

AU - Takatori, Yoshio

AU - Yamada, Harumoto

AU - Yasunaga, Yuji

AU - Ito, Hiroshi

AU - Mori, Satoshi

AU - Owan, Ichiro

AU - Fujii, Genji

AU - Ohashi, Hirotsugu

AU - Takahashi, Shinji

AU - Hirota, Yoshio

PY - 2016/8/2

Y1 - 2016/8/2

N2 - Background: In Japan, the majority of hip osteoarthritis (OA) was caused by acetabular dysplasia, and about 90 % of patients were female. The present study focused on Japanese female patients with hip OA due to acetabular dysplasia, and examined the associated factors with OA staging at diagnosis, in special reference to body weight. Methods: Study subjects were 336 Japanese women who were newly diagnosed with hip OA caused by acetabular dysplasia at 15 hospitals in 2008. The self-administered questionnaire elicited patients' body weight at age 20 and at OA diagnosis. Four ranked OA staging according to radiographic findings of the hip joint (pre-OA, initial stage, advanced stage or terminal stage) was regarded as the outcome index. Proportional odds models in logistic regression were used to calculate odds ratios (ORs) and 95 % confidence intervals (CIs) for severer stage of OA. Results: At diagnosis, 45 % of patients suffered from terminal stage of OA, whereas 13 % and 14 % were categorized into pre-OA and initial stage, respectively. After adjustment for potential confounders, weight gain since age 20 revealed the increased ORs for severer OA stage at diagnosis (OR 2.02; 95 % CI, 1.07-3.80). Other significant characteristics were age (67+ vs. 20-49 years, OR 12.4), lower education (junior high school vs. junior college or higher, OR 4.00), parity (OR 2.19), lower acetabular head index (<60.0 vs. 71.1+, OR 2.36), and longer duration since symptom onset (6.0+ vs. <1.0 year, OR 2.94). Conclusions: Weight gain since age 20 might be involved in mechanisms of OA development, which is independent of age or severity of acetabular dysplasia.

AB - Background: In Japan, the majority of hip osteoarthritis (OA) was caused by acetabular dysplasia, and about 90 % of patients were female. The present study focused on Japanese female patients with hip OA due to acetabular dysplasia, and examined the associated factors with OA staging at diagnosis, in special reference to body weight. Methods: Study subjects were 336 Japanese women who were newly diagnosed with hip OA caused by acetabular dysplasia at 15 hospitals in 2008. The self-administered questionnaire elicited patients' body weight at age 20 and at OA diagnosis. Four ranked OA staging according to radiographic findings of the hip joint (pre-OA, initial stage, advanced stage or terminal stage) was regarded as the outcome index. Proportional odds models in logistic regression were used to calculate odds ratios (ORs) and 95 % confidence intervals (CIs) for severer stage of OA. Results: At diagnosis, 45 % of patients suffered from terminal stage of OA, whereas 13 % and 14 % were categorized into pre-OA and initial stage, respectively. After adjustment for potential confounders, weight gain since age 20 revealed the increased ORs for severer OA stage at diagnosis (OR 2.02; 95 % CI, 1.07-3.80). Other significant characteristics were age (67+ vs. 20-49 years, OR 12.4), lower education (junior high school vs. junior college or higher, OR 4.00), parity (OR 2.19), lower acetabular head index (<60.0 vs. 71.1+, OR 2.36), and longer duration since symptom onset (6.0+ vs. <1.0 year, OR 2.94). Conclusions: Weight gain since age 20 might be involved in mechanisms of OA development, which is independent of age or severity of acetabular dysplasia.

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U2 - 10.1186/s12891-016-1179-4

DO - 10.1186/s12891-016-1179-4

M3 - Article

C2 - 27484820

AN - SCOPUS:84987948174

VL - 17

JO - BMC Musculoskeletal Disorders

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