TY - JOUR
T1 - Factors associated with progression of non-motor symptoms and deterioration in quality of life in Parkinson's disease
T2 - Results of J-FIRST, a 1-year observational study
AU - the J-FIRST group
AU - Kashihara, Kenichi
AU - Chiu, Shih Wei
AU - Tsuboi, Yoshio
AU - Hattori, Nobutaka
AU - Nomoto, Masahiro
AU - Watanabe, Hirohisa
AU - Maeda, Tetsuya
AU - Saiki, Hidemoto
AU - Shimo, Yasushi
AU - Yamaguchi, Takuhiro
AU - Abe, Takashi
AU - Hasegawa, Kazuko
AU - Hattori, Tatsuya
AU - Hazama, Takanori
AU - Hirano, Shigeki
AU - Hirata, Koichi
AU - Iijima, Mutsumi
AU - Ito, Mizuki
AU - Itoh, Kazunori
AU - Kamei, Satoshi
AU - Kikuchi, Seiji
AU - Kurisaki, Ryoichi
AU - Kusaka, Hirofumi
AU - Mihara, Masahito
AU - Miwa, Hideto
AU - Miyachi, Takafumi
AU - Mori, Hideo
AU - Murata, Miho
AU - Nagayama, Hiroshi
AU - Nishiyama, Kazutoshi
AU - Ohkubo, Ryuichi
AU - Saigo, Ryuji
AU - Takahashi, Makio
AU - Takahashi, Ryosuke
AU - Takeda, Atsushi
AU - Tatsuoka, Yoshihisa
AU - Toda, Kazuo
AU - Tomiyama, Masahiko
AU - Yamamoto, Mitsutoshi
AU - Yoshinaga, Junji
N1 - Publisher Copyright:
© 2024 The Author(s). Neurology and Clinical Neuroscience published by Japanese Society of Neurology and John Wiley & Sons Australia, Ltd.
PY - 2025/1
Y1 - 2025/1
N2 - Background: Worsening motor symptoms are associated with deteriorations in health-related quality of life (HrQOL) in patients with Parkinson's disease (PD). Aim: Because few studies have examined whether non-motor symptoms (NMSs) predict worsening of overall NMSs and HrQOL, we investigated whether NMSs are associated with the changes in these outcomes in patients with PD. Methods: We used data from J-FIRST, a 52-week study of patients with PD, ≥1 NMS, and wearing-off under levodopa treatment. Changes in Movement Disorders Society–Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part I and 8-item Parkinson's Disease Questionnaire (PDQ-8) total scores during the observation period were compared between patients with and without individual NMSs at baseline. Relationships among NMSs were analyzed by cluster analysis. Results: The analyses comprised 996 patients. The MDS-UPDRS Part I total scores significantly increased in patients with cognitive impairment, depressed mood, and apathy, but significantly decreased in patients with features of dopamine dysregulation syndrome, relative to the changes in patients without these NMSs at baseline. The PDQ-8 total scores significantly increased in patients with cognitive impairment, hallucinations and psychosis, depressed mood, apathy, pain and other sensations, urinary problems, and fatigue relative to the changes in patients without these NMSs at baseline. NMSs were broadly clustered into cognitive/mental functions, and autonomic functions and sleep. Light headedness on standing, fatigue, and pain and other sensations were closely related. Conclusion: We observed significant deteriorations in the NMS burden and HrQOL in patients with cognitive, mental, or autonomic-related NMSs.
AB - Background: Worsening motor symptoms are associated with deteriorations in health-related quality of life (HrQOL) in patients with Parkinson's disease (PD). Aim: Because few studies have examined whether non-motor symptoms (NMSs) predict worsening of overall NMSs and HrQOL, we investigated whether NMSs are associated with the changes in these outcomes in patients with PD. Methods: We used data from J-FIRST, a 52-week study of patients with PD, ≥1 NMS, and wearing-off under levodopa treatment. Changes in Movement Disorders Society–Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part I and 8-item Parkinson's Disease Questionnaire (PDQ-8) total scores during the observation period were compared between patients with and without individual NMSs at baseline. Relationships among NMSs were analyzed by cluster analysis. Results: The analyses comprised 996 patients. The MDS-UPDRS Part I total scores significantly increased in patients with cognitive impairment, depressed mood, and apathy, but significantly decreased in patients with features of dopamine dysregulation syndrome, relative to the changes in patients without these NMSs at baseline. The PDQ-8 total scores significantly increased in patients with cognitive impairment, hallucinations and psychosis, depressed mood, apathy, pain and other sensations, urinary problems, and fatigue relative to the changes in patients without these NMSs at baseline. NMSs were broadly clustered into cognitive/mental functions, and autonomic functions and sleep. Light headedness on standing, fatigue, and pain and other sensations were closely related. Conclusion: We observed significant deteriorations in the NMS burden and HrQOL in patients with cognitive, mental, or autonomic-related NMSs.
KW - disease progression
KW - health-related quality of life
KW - non-motor symptoms
KW - observational study
KW - Parkinson's disease
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UR - http://www.scopus.com/inward/citedby.url?scp=85201283163&partnerID=8YFLogxK
U2 - 10.1111/ncn3.12846
DO - 10.1111/ncn3.12846
M3 - Article
AN - SCOPUS:85201283163
SN - 2049-4173
VL - 13
SP - 37
EP - 47
JO - Neurology and Clinical Neuroscience
JF - Neurology and Clinical Neuroscience
IS - 1
ER -