Factors correlating with acoustic radiation force impulse elastography in chronic hepatitis C

Toru Nishikawa, Senju Hashimoto, Naoto Kawabe, Masao Harata, Yoshifumi Nitta, Michihito Murao, Takuji Nakano, Yuko Mizuno, Hiroaki Shimazaki, Toshiki Kan, Kazunori Nakaoka, Yuka Takagawa, Masashi Ohki, Naohiro Ichino, Keisuke Osakabe, Kentaro Yoshioka

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

AIM: To investigate the factors other than fibrosis stage correlating with acoustic radiation force impulse (ARFI) elastograpy in chronic hepatitis C. METHODS: ARFI elastograpy was performed in 108 consecutive patients with chronic hepatitis C who underwent a liver biopsy. The proportion of fibrosis area in the biopsy specimens was measured by computerassisted morphometric image analysis. RESULTS: ARFI correlated significantly with fibrosis stage (β = 0.1865, P < 0.0001) and hyaluronic acid levels (β = 0.0008, P = 0.0039) in all patients by multiple regression analysis. Fibrosis area correlated sigsignificantly with ARFI by Spearman's rank correlation test but not by multiple regression analysis. ARFI correlated significantly with body mass index (BMI) (β = -0.0334, P = 0.0001) in F 0 or F 1, with γ-glutamyltranspeptidase levels (β = 0.0048, P = 0.0012) in F 2, and with fibrosis stage (β = 0.2921, P = 0.0044) and hyaluronic acid levels (β = 0.0012, P = 0.0025) in F 3 or F 4. The ARFI cutoff value was 1.28 m/s for F ≥ 2, 1.44 m/s for F ≥ 3, and 1.73 m/s for F 4. CONCLUSION: ARFI correlated with fibrosis stage and hyaluronic acid but not with inflammation. ARFI was affected by BMI, γ-glutamyltranspeptidase, and hyaluronic acid in each fibrosis stage.

Original languageEnglish
Pages (from-to)1289-1297
Number of pages9
JournalWorld Journal of Gastroenterology
Volume20
Issue number5
DOIs
Publication statusPublished - 07-02-2014

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Elasticity Imaging Techniques
Chronic Hepatitis C
Acoustics
Fibrosis
Radiation
Hyaluronic Acid
Body Mass Index
Regression Analysis
Biopsy
Inflammation
Liver

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Nishikawa, T., Hashimoto, S., Kawabe, N., Harata, M., Nitta, Y., Murao, M., ... Yoshioka, K. (2014). Factors correlating with acoustic radiation force impulse elastography in chronic hepatitis C. World Journal of Gastroenterology, 20(5), 1289-1297. https://doi.org/10.3748/wjg.v20.i5.1289
Nishikawa, Toru ; Hashimoto, Senju ; Kawabe, Naoto ; Harata, Masao ; Nitta, Yoshifumi ; Murao, Michihito ; Nakano, Takuji ; Mizuno, Yuko ; Shimazaki, Hiroaki ; Kan, Toshiki ; Nakaoka, Kazunori ; Takagawa, Yuka ; Ohki, Masashi ; Ichino, Naohiro ; Osakabe, Keisuke ; Yoshioka, Kentaro. / Factors correlating with acoustic radiation force impulse elastography in chronic hepatitis C. In: World Journal of Gastroenterology. 2014 ; Vol. 20, No. 5. pp. 1289-1297.
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abstract = "AIM: To investigate the factors other than fibrosis stage correlating with acoustic radiation force impulse (ARFI) elastograpy in chronic hepatitis C. METHODS: ARFI elastograpy was performed in 108 consecutive patients with chronic hepatitis C who underwent a liver biopsy. The proportion of fibrosis area in the biopsy specimens was measured by computerassisted morphometric image analysis. RESULTS: ARFI correlated significantly with fibrosis stage (β = 0.1865, P < 0.0001) and hyaluronic acid levels (β = 0.0008, P = 0.0039) in all patients by multiple regression analysis. Fibrosis area correlated sigsignificantly with ARFI by Spearman's rank correlation test but not by multiple regression analysis. ARFI correlated significantly with body mass index (BMI) (β = -0.0334, P = 0.0001) in F 0 or F 1, with γ-glutamyltranspeptidase levels (β = 0.0048, P = 0.0012) in F 2, and with fibrosis stage (β = 0.2921, P = 0.0044) and hyaluronic acid levels (β = 0.0012, P = 0.0025) in F 3 or F 4. The ARFI cutoff value was 1.28 m/s for F ≥ 2, 1.44 m/s for F ≥ 3, and 1.73 m/s for F 4. CONCLUSION: ARFI correlated with fibrosis stage and hyaluronic acid but not with inflammation. ARFI was affected by BMI, γ-glutamyltranspeptidase, and hyaluronic acid in each fibrosis stage.",
author = "Toru Nishikawa and Senju Hashimoto and Naoto Kawabe and Masao Harata and Yoshifumi Nitta and Michihito Murao and Takuji Nakano and Yuko Mizuno and Hiroaki Shimazaki and Toshiki Kan and Kazunori Nakaoka and Yuka Takagawa and Masashi Ohki and Naohiro Ichino and Keisuke Osakabe and Kentaro Yoshioka",
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Nishikawa, T, Hashimoto, S, Kawabe, N, Harata, M, Nitta, Y, Murao, M, Nakano, T, Mizuno, Y, Shimazaki, H, Kan, T, Nakaoka, K, Takagawa, Y, Ohki, M, Ichino, N, Osakabe, K & Yoshioka, K 2014, 'Factors correlating with acoustic radiation force impulse elastography in chronic hepatitis C', World Journal of Gastroenterology, vol. 20, no. 5, pp. 1289-1297. https://doi.org/10.3748/wjg.v20.i5.1289

Factors correlating with acoustic radiation force impulse elastography in chronic hepatitis C. / Nishikawa, Toru; Hashimoto, Senju; Kawabe, Naoto; Harata, Masao; Nitta, Yoshifumi; Murao, Michihito; Nakano, Takuji; Mizuno, Yuko; Shimazaki, Hiroaki; Kan, Toshiki; Nakaoka, Kazunori; Takagawa, Yuka; Ohki, Masashi; Ichino, Naohiro; Osakabe, Keisuke; Yoshioka, Kentaro.

In: World Journal of Gastroenterology, Vol. 20, No. 5, 07.02.2014, p. 1289-1297.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Factors correlating with acoustic radiation force impulse elastography in chronic hepatitis C

AU - Nishikawa, Toru

AU - Hashimoto, Senju

AU - Kawabe, Naoto

AU - Harata, Masao

AU - Nitta, Yoshifumi

AU - Murao, Michihito

AU - Nakano, Takuji

AU - Mizuno, Yuko

AU - Shimazaki, Hiroaki

AU - Kan, Toshiki

AU - Nakaoka, Kazunori

AU - Takagawa, Yuka

AU - Ohki, Masashi

AU - Ichino, Naohiro

AU - Osakabe, Keisuke

AU - Yoshioka, Kentaro

PY - 2014/2/7

Y1 - 2014/2/7

N2 - AIM: To investigate the factors other than fibrosis stage correlating with acoustic radiation force impulse (ARFI) elastograpy in chronic hepatitis C. METHODS: ARFI elastograpy was performed in 108 consecutive patients with chronic hepatitis C who underwent a liver biopsy. The proportion of fibrosis area in the biopsy specimens was measured by computerassisted morphometric image analysis. RESULTS: ARFI correlated significantly with fibrosis stage (β = 0.1865, P < 0.0001) and hyaluronic acid levels (β = 0.0008, P = 0.0039) in all patients by multiple regression analysis. Fibrosis area correlated sigsignificantly with ARFI by Spearman's rank correlation test but not by multiple regression analysis. ARFI correlated significantly with body mass index (BMI) (β = -0.0334, P = 0.0001) in F 0 or F 1, with γ-glutamyltranspeptidase levels (β = 0.0048, P = 0.0012) in F 2, and with fibrosis stage (β = 0.2921, P = 0.0044) and hyaluronic acid levels (β = 0.0012, P = 0.0025) in F 3 or F 4. The ARFI cutoff value was 1.28 m/s for F ≥ 2, 1.44 m/s for F ≥ 3, and 1.73 m/s for F 4. CONCLUSION: ARFI correlated with fibrosis stage and hyaluronic acid but not with inflammation. ARFI was affected by BMI, γ-glutamyltranspeptidase, and hyaluronic acid in each fibrosis stage.

AB - AIM: To investigate the factors other than fibrosis stage correlating with acoustic radiation force impulse (ARFI) elastograpy in chronic hepatitis C. METHODS: ARFI elastograpy was performed in 108 consecutive patients with chronic hepatitis C who underwent a liver biopsy. The proportion of fibrosis area in the biopsy specimens was measured by computerassisted morphometric image analysis. RESULTS: ARFI correlated significantly with fibrosis stage (β = 0.1865, P < 0.0001) and hyaluronic acid levels (β = 0.0008, P = 0.0039) in all patients by multiple regression analysis. Fibrosis area correlated sigsignificantly with ARFI by Spearman's rank correlation test but not by multiple regression analysis. ARFI correlated significantly with body mass index (BMI) (β = -0.0334, P = 0.0001) in F 0 or F 1, with γ-glutamyltranspeptidase levels (β = 0.0048, P = 0.0012) in F 2, and with fibrosis stage (β = 0.2921, P = 0.0044) and hyaluronic acid levels (β = 0.0012, P = 0.0025) in F 3 or F 4. The ARFI cutoff value was 1.28 m/s for F ≥ 2, 1.44 m/s for F ≥ 3, and 1.73 m/s for F 4. CONCLUSION: ARFI correlated with fibrosis stage and hyaluronic acid but not with inflammation. ARFI was affected by BMI, γ-glutamyltranspeptidase, and hyaluronic acid in each fibrosis stage.

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