factors predicting bone mineral density (BMD) changes in young women over a One-Year study: Changes in body weight and bone metabolic markers during the menstrual cycle and their effects on BMD

Tadayuki Iida, Chiho Chikamur, Hiroaki Ishikawa, Satomi Aoirf, Hiromi Ikeda, Toshihide Haradae, Kazuhiro Katada, Fumiko Ishizaki, Hiroshi Yatsuya, Yuichiro Ono

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Currently, 26% of Japanese women in their twenties are under weight, and therefore at risk of developing various metabolic abnormalities due to an inadequate nutrient intake, which in turn affects the acquisition of a peak bone mineral density (BMD). In this study, we aimed to clarify the effects of menstrual cycle-related changes in body weight and bone metabolic marker levels on the BMD changes. The subjects were 42 women (19.6 ± 0.8 years). The levels of osteocalcin (OC), BAP, s-NTx, u-DPD, and E2 in the menstrual and ovulatory phases were measured. The associations between dependent variables (BMD changes/year in the lumbar spine, femur, femoral neck) and explanatory variables (body weight changes/year, the levels of OC, BAP, s-NTx, u-DPD) were evaluated using multiple regression analysis. Analysis of the correlations between the changes in bone metabolic markers and changes in BMD showed a correlation between the OC level in the menstrual phase and changes in the BMD of the entire femur, suggesting that a high OC level protects against BMD reduction, probably by promoting osteoblast activity, and that bone formation activity suppresses the decrease in BMD. These results suggest that, to predict BMD changes from bone metabolic markers in young women, it is necessary to measure OC levels in the menstrual phase.

Original languageEnglish
Pages (from-to)307-315
Number of pages9
JournalActa Medica Okayama
Volume66
Issue number4
Publication statusPublished - 25-10-2012

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Body Weight Changes
Menstrual Cycle
Bone Density
Minerals
Bone
Osteocalcin
Bone and Bones
Femur Neck
Osteoblasts
Osteogenesis
Femur
Spine
Regression Analysis
Weights and Measures
Regression analysis
Food
Nutrients

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Iida, Tadayuki ; Chikamur, Chiho ; Ishikawa, Hiroaki ; Aoirf, Satomi ; Ikeda, Hiromi ; Haradae, Toshihide ; Katada, Kazuhiro ; Ishizaki, Fumiko ; Yatsuya, Hiroshi ; Ono, Yuichiro. / factors predicting bone mineral density (BMD) changes in young women over a One-Year study : Changes in body weight and bone metabolic markers during the menstrual cycle and their effects on BMD. In: Acta Medica Okayama. 2012 ; Vol. 66, No. 4. pp. 307-315.
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factors predicting bone mineral density (BMD) changes in young women over a One-Year study : Changes in body weight and bone metabolic markers during the menstrual cycle and their effects on BMD. / Iida, Tadayuki; Chikamur, Chiho; Ishikawa, Hiroaki; Aoirf, Satomi; Ikeda, Hiromi; Haradae, Toshihide; Katada, Kazuhiro; Ishizaki, Fumiko; Yatsuya, Hiroshi; Ono, Yuichiro.

In: Acta Medica Okayama, Vol. 66, No. 4, 25.10.2012, p. 307-315.

Research output: Contribution to journalArticle

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AU - Iida, Tadayuki

AU - Chikamur, Chiho

AU - Ishikawa, Hiroaki

AU - Aoirf, Satomi

AU - Ikeda, Hiromi

AU - Haradae, Toshihide

AU - Katada, Kazuhiro

AU - Ishizaki, Fumiko

AU - Yatsuya, Hiroshi

AU - Ono, Yuichiro

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