TY - JOUR
T1 - Factors responsible for neurofibrillary tangles and neuronal cell losses in tauopathy
AU - Wakasaya, Yasuhito
AU - Kawarabayashi, Takeshi
AU - Watanabe, Mitsunori
AU - Yamamoto-Watanabe, Yukiko
AU - Takamura, Ayumi
AU - Kurata, Tomoko
AU - Murakami, Tetsuro
AU - Abe, Koji
AU - Yamada, Kiyofumi
AU - Wakabayashi, Koichi
AU - Sasaki, Atsushi
AU - Westaway, David
AU - Hyslop, Peter St George
AU - Matsubara, Etsuro
AU - Shoji, Mikio
PY - 2011/4
Y1 - 2011/4
N2 - TgTauP301L mice that overexpress the mutant human tauP301L present in FTDP-17 reproduce neurofibrillary tangles (NFTs), neuronal cell losses, memory disturbance, and substantial phenotypic variation. To demonstrate factors responsible for NFT formation and neuronal cell losses, sets of TgTauP301L for comparison with or without NFTs and neuronal cell losses were studied with oligonucleotide microarrays. Gene expressions were altered in biological pathways, including oxidative stress, apoptosis, mitochondrial fatty acid betaoxidation, inflammatory response pathway, and complement and coagulation cascade pathways. Among 24 altered genes, increased levels of apolipoprotein D (ApoD) and neuronal PAS domain protein 4 (Npas4) and decreased levels of doublecortin (DCX) and potassium channel, voltage-gated, shaker-related subfamily, β member 1 (Kcnab1) were found in the TgTauP301L with NFTs and neuronal cell losses, Alzheimer's brains, and tauopathy brains. Thus, many biological pathways and novel molecules are associated with NFT formation and neuronal cell losses in tauopathy brains.
AB - TgTauP301L mice that overexpress the mutant human tauP301L present in FTDP-17 reproduce neurofibrillary tangles (NFTs), neuronal cell losses, memory disturbance, and substantial phenotypic variation. To demonstrate factors responsible for NFT formation and neuronal cell losses, sets of TgTauP301L for comparison with or without NFTs and neuronal cell losses were studied with oligonucleotide microarrays. Gene expressions were altered in biological pathways, including oxidative stress, apoptosis, mitochondrial fatty acid betaoxidation, inflammatory response pathway, and complement and coagulation cascade pathways. Among 24 altered genes, increased levels of apolipoprotein D (ApoD) and neuronal PAS domain protein 4 (Npas4) and decreased levels of doublecortin (DCX) and potassium channel, voltage-gated, shaker-related subfamily, β member 1 (Kcnab1) were found in the TgTauP301L with NFTs and neuronal cell losses, Alzheimer's brains, and tauopathy brains. Thus, many biological pathways and novel molecules are associated with NFT formation and neuronal cell losses in tauopathy brains.
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U2 - 10.1002/jnr.22572
DO - 10.1002/jnr.22572
M3 - Article
C2 - 21312224
AN - SCOPUS:79751491801
SN - 0360-4012
VL - 89
SP - 576
EP - 584
JO - Journal of Neuroscience Research
JF - Journal of Neuroscience Research
IS - 4
ER -