TY - JOUR
T1 - Failure to confirm the association between the FEZ1 gene and schizophrenia in a Japanese population
AU - Koga, Minori
AU - Ishiguro, Hiroki
AU - Horiuchi, Yasue
AU - Albalushi, Talal
AU - Inada, Toshiya
AU - Iwata, Nakao
AU - Ozaki, Norio
AU - Ujike, Hiroshi
AU - Muratake, Tatsuyuki
AU - Someya, Toshiyuki
AU - Arinami, Tadao
PY - 2007/5/7
Y1 - 2007/5/7
N2 - Fasciculation and elongation of protein zeta-1 (FEZ1) is a binding partner of Disrupted-In-Schizophrenia 1 (DISC1). Because the DISC1 gene is shown to be a causative gene for psychosis in a Scottish family, the FEZ1 gene may well have importance in mental disease. A previous association study that analyzed polymorphisms of the FEZ1 gene in Japanese patients with schizophrenia and control subjects found significant association of the Asp123Glu polymorphism with schizophrenia. In the present study, we examined two polymorphic markers, rs559668 and rs597570 (Asp123Glu), in the FEZ1 gene to confirm the association in 1920 Japanese patients with schizophrenia and 1920 control subjects. The power to detect an association was more than 0.98. However, we did not detect genotypic associations of either of these two single nucleotide polymorphisms with schizophrenia (p = 1 and 0.79, respectively). We concluded that the missense mutation Asp123Glu of the FEZ1 gene is unlikely to play a substantial role in the genetic susceptibility to schizophrenia.
AB - Fasciculation and elongation of protein zeta-1 (FEZ1) is a binding partner of Disrupted-In-Schizophrenia 1 (DISC1). Because the DISC1 gene is shown to be a causative gene for psychosis in a Scottish family, the FEZ1 gene may well have importance in mental disease. A previous association study that analyzed polymorphisms of the FEZ1 gene in Japanese patients with schizophrenia and control subjects found significant association of the Asp123Glu polymorphism with schizophrenia. In the present study, we examined two polymorphic markers, rs559668 and rs597570 (Asp123Glu), in the FEZ1 gene to confirm the association in 1920 Japanese patients with schizophrenia and 1920 control subjects. The power to detect an association was more than 0.98. However, we did not detect genotypic associations of either of these two single nucleotide polymorphisms with schizophrenia (p = 1 and 0.79, respectively). We concluded that the missense mutation Asp123Glu of the FEZ1 gene is unlikely to play a substantial role in the genetic susceptibility to schizophrenia.
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U2 - 10.1016/j.neulet.2007.02.055
DO - 10.1016/j.neulet.2007.02.055
M3 - Article
C2 - 17374448
AN - SCOPUS:34247167580
SN - 0304-3940
VL - 417
SP - 326
EP - 329
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 3
ER -