Failure to find an association between myosin heavy chain 9, non-muscle (MYH9) and schizophrenia: A three-stage case-control association study

Hideki Amagane, Yuichiro Watanabe, Naoshi Kaneko, Ayako Nunokawa, Tatsuyuki Muratake, Hiroki Ishiguro, Tadao Arinami, Hiroshi Ujike, Toshiya Inada, Nakao Iwata, Hiroshi Kunugi, Tsukasa Sasaki, Ryota Hashimoto, Masanari Itokawa, Norio Ozaki, Toshiyuki Someya

Research output: Contribution to journalArticle

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Abstract

Several genome-wide linkage studies have suggested linkage between markers on the long arm of chromosome 22 and schizophrenia. It has also been reported that 22q11.2 deletions increase the risk of schizophrenia. Therefore, 22q is a candidate region for schizophrenia. To search for genetic susceptibility loci for schizophrenia on 22q, we conducted a three-stage case-control association study in Japanese individuals. In the first stage, we examined 13 microsatellite markers on 22q in 766 individuals (340 patients with schizophrenia and 426 control individuals) and found a potential association of AFM262VH5 (D22S283) with schizophrenia. In the second stage, we performed fine mapping of the myosin heavy chain 9, non-muscle (MYH9) gene, where AFM262VH5 is located, using 25 tagging single nucleotide polymorphisms (SNPs). We obtained potential associations between three SNPs in MYH9 and schizophrenia in 1193 individuals (595 patients and 598 controls), which included the individuals analyzed in the first stage. In the third stage, however, we could not replicate these associations in 4694 independent individuals (2288 patients and 2406 controls). Our results suggest that MYH9 does not confer increased susceptibility to schizophrenia in the Japanese population, although we could not exclude possible contributions of other genes on 22q to the pathogenesis of schizophrenia.

Original languageEnglish
Pages (from-to)106-112
Number of pages7
JournalSchizophrenia Research
Volume118
Issue number1-3
DOIs
Publication statusPublished - 01-05-2010

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Myosin Heavy Chains
Case-Control Studies
Schizophrenia
Single Nucleotide Polymorphism
Chromosomes, Human, Pair 22
Genetic Loci
Genetic Predisposition to Disease
Microsatellite Repeats
Genes
Genome

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Amagane, Hideki ; Watanabe, Yuichiro ; Kaneko, Naoshi ; Nunokawa, Ayako ; Muratake, Tatsuyuki ; Ishiguro, Hiroki ; Arinami, Tadao ; Ujike, Hiroshi ; Inada, Toshiya ; Iwata, Nakao ; Kunugi, Hiroshi ; Sasaki, Tsukasa ; Hashimoto, Ryota ; Itokawa, Masanari ; Ozaki, Norio ; Someya, Toshiyuki. / Failure to find an association between myosin heavy chain 9, non-muscle (MYH9) and schizophrenia : A three-stage case-control association study. In: Schizophrenia Research. 2010 ; Vol. 118, No. 1-3. pp. 106-112.
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abstract = "Several genome-wide linkage studies have suggested linkage between markers on the long arm of chromosome 22 and schizophrenia. It has also been reported that 22q11.2 deletions increase the risk of schizophrenia. Therefore, 22q is a candidate region for schizophrenia. To search for genetic susceptibility loci for schizophrenia on 22q, we conducted a three-stage case-control association study in Japanese individuals. In the first stage, we examined 13 microsatellite markers on 22q in 766 individuals (340 patients with schizophrenia and 426 control individuals) and found a potential association of AFM262VH5 (D22S283) with schizophrenia. In the second stage, we performed fine mapping of the myosin heavy chain 9, non-muscle (MYH9) gene, where AFM262VH5 is located, using 25 tagging single nucleotide polymorphisms (SNPs). We obtained potential associations between three SNPs in MYH9 and schizophrenia in 1193 individuals (595 patients and 598 controls), which included the individuals analyzed in the first stage. In the third stage, however, we could not replicate these associations in 4694 independent individuals (2288 patients and 2406 controls). Our results suggest that MYH9 does not confer increased susceptibility to schizophrenia in the Japanese population, although we could not exclude possible contributions of other genes on 22q to the pathogenesis of schizophrenia.",
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Amagane, H, Watanabe, Y, Kaneko, N, Nunokawa, A, Muratake, T, Ishiguro, H, Arinami, T, Ujike, H, Inada, T, Iwata, N, Kunugi, H, Sasaki, T, Hashimoto, R, Itokawa, M, Ozaki, N & Someya, T 2010, 'Failure to find an association between myosin heavy chain 9, non-muscle (MYH9) and schizophrenia: A three-stage case-control association study', Schizophrenia Research, vol. 118, no. 1-3, pp. 106-112. https://doi.org/10.1016/j.schres.2010.01.023

Failure to find an association between myosin heavy chain 9, non-muscle (MYH9) and schizophrenia : A three-stage case-control association study. / Amagane, Hideki; Watanabe, Yuichiro; Kaneko, Naoshi; Nunokawa, Ayako; Muratake, Tatsuyuki; Ishiguro, Hiroki; Arinami, Tadao; Ujike, Hiroshi; Inada, Toshiya; Iwata, Nakao; Kunugi, Hiroshi; Sasaki, Tsukasa; Hashimoto, Ryota; Itokawa, Masanari; Ozaki, Norio; Someya, Toshiyuki.

In: Schizophrenia Research, Vol. 118, No. 1-3, 01.05.2010, p. 106-112.

Research output: Contribution to journalArticle

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T1 - Failure to find an association between myosin heavy chain 9, non-muscle (MYH9) and schizophrenia

T2 - A three-stage case-control association study

AU - Amagane, Hideki

AU - Watanabe, Yuichiro

AU - Kaneko, Naoshi

AU - Nunokawa, Ayako

AU - Muratake, Tatsuyuki

AU - Ishiguro, Hiroki

AU - Arinami, Tadao

AU - Ujike, Hiroshi

AU - Inada, Toshiya

AU - Iwata, Nakao

AU - Kunugi, Hiroshi

AU - Sasaki, Tsukasa

AU - Hashimoto, Ryota

AU - Itokawa, Masanari

AU - Ozaki, Norio

AU - Someya, Toshiyuki

PY - 2010/5/1

Y1 - 2010/5/1

N2 - Several genome-wide linkage studies have suggested linkage between markers on the long arm of chromosome 22 and schizophrenia. It has also been reported that 22q11.2 deletions increase the risk of schizophrenia. Therefore, 22q is a candidate region for schizophrenia. To search for genetic susceptibility loci for schizophrenia on 22q, we conducted a three-stage case-control association study in Japanese individuals. In the first stage, we examined 13 microsatellite markers on 22q in 766 individuals (340 patients with schizophrenia and 426 control individuals) and found a potential association of AFM262VH5 (D22S283) with schizophrenia. In the second stage, we performed fine mapping of the myosin heavy chain 9, non-muscle (MYH9) gene, where AFM262VH5 is located, using 25 tagging single nucleotide polymorphisms (SNPs). We obtained potential associations between three SNPs in MYH9 and schizophrenia in 1193 individuals (595 patients and 598 controls), which included the individuals analyzed in the first stage. In the third stage, however, we could not replicate these associations in 4694 independent individuals (2288 patients and 2406 controls). Our results suggest that MYH9 does not confer increased susceptibility to schizophrenia in the Japanese population, although we could not exclude possible contributions of other genes on 22q to the pathogenesis of schizophrenia.

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