Familial aggregation and coaggregation of history of hypertension and stroke

T. Kondo, H. Toyoshima, Y. Tsuzuki, Y. Hori, Hiroshi Yatsuya, K. Tamakoshi, A. Tamakoshi, Y. Ohno, Kunio Aoki, Haruo Sugano

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We attempted to evaluate familial aggregation and coaggregation of history of hypertension and stroke. Past and family history of hypertension and stroke for 83 089 probands and their relatives were obtained from a data set for the Japan Collaborative Cohort Study for Evaluation of Cancer Risk sponsored by the Ministry of Education (JACC Study), which was initiated from 1988 to 1990. First, evaluation was performed for familial aggregation of each of two disorders using ordinal logistic regression of the generalized estimation equations (GEE) to account for dependence of observations within families. Secondly, in order to evaluate the familial congregation of the history of hypertension and stroke, a GEE-based multivariate probed predictive model was applied. After adjusting for the proband's age, level of obesity, smoking status, drinking status, habitation area, and the gender and type of the relatives, the estimated odds ratios for the intraindividual clustering and familial aggregation of the disease history showed statistically significant relationships. In addition, the history of the two disorders showed a significant relationship in terms of familial coaggregation independently of the aggregation of each disorder itself. Our results confirmed that hypertension and stroke coaggregate strongly within families through possible effects of genetic factors, which, alone or in conjunction with environmental factors, influence susceptibility to both hypertension and stroke.

Original languageEnglish
Pages (from-to)119-125
Number of pages7
JournalJournal of Human Hypertension
Volume19
Issue number2
DOIs
Publication statusPublished - 01-02-2005

Fingerprint

Stroke
Hypertension
History
Odds Ratio
Drinking
Cluster Analysis
Japan
Cohort Studies
Obesity
Logistic Models
Smoking
Education
Neoplasms

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Kondo, T., Toyoshima, H., Tsuzuki, Y., Hori, Y., Yatsuya, H., Tamakoshi, K., ... Sugano, H. (2005). Familial aggregation and coaggregation of history of hypertension and stroke. Journal of Human Hypertension, 19(2), 119-125. https://doi.org/10.1038/sj.jhh.1001788
Kondo, T. ; Toyoshima, H. ; Tsuzuki, Y. ; Hori, Y. ; Yatsuya, Hiroshi ; Tamakoshi, K. ; Tamakoshi, A. ; Ohno, Y. ; Aoki, Kunio ; Sugano, Haruo. / Familial aggregation and coaggregation of history of hypertension and stroke. In: Journal of Human Hypertension. 2005 ; Vol. 19, No. 2. pp. 119-125.
@article{57af9cea213c4746a3275c4e62d573d3,
title = "Familial aggregation and coaggregation of history of hypertension and stroke",
abstract = "We attempted to evaluate familial aggregation and coaggregation of history of hypertension and stroke. Past and family history of hypertension and stroke for 83 089 probands and their relatives were obtained from a data set for the Japan Collaborative Cohort Study for Evaluation of Cancer Risk sponsored by the Ministry of Education (JACC Study), which was initiated from 1988 to 1990. First, evaluation was performed for familial aggregation of each of two disorders using ordinal logistic regression of the generalized estimation equations (GEE) to account for dependence of observations within families. Secondly, in order to evaluate the familial congregation of the history of hypertension and stroke, a GEE-based multivariate probed predictive model was applied. After adjusting for the proband's age, level of obesity, smoking status, drinking status, habitation area, and the gender and type of the relatives, the estimated odds ratios for the intraindividual clustering and familial aggregation of the disease history showed statistically significant relationships. In addition, the history of the two disorders showed a significant relationship in terms of familial coaggregation independently of the aggregation of each disorder itself. Our results confirmed that hypertension and stroke coaggregate strongly within families through possible effects of genetic factors, which, alone or in conjunction with environmental factors, influence susceptibility to both hypertension and stroke.",
author = "T. Kondo and H. Toyoshima and Y. Tsuzuki and Y. Hori and Hiroshi Yatsuya and K. Tamakoshi and A. Tamakoshi and Y. Ohno and Kunio Aoki and Haruo Sugano",
year = "2005",
month = "2",
day = "1",
doi = "10.1038/sj.jhh.1001788",
language = "English",
volume = "19",
pages = "119--125",
journal = "Journal of Human Hypertension",
issn = "0950-9240",
publisher = "Nature Publishing Group",
number = "2",

}

Kondo, T, Toyoshima, H, Tsuzuki, Y, Hori, Y, Yatsuya, H, Tamakoshi, K, Tamakoshi, A, Ohno, Y, Aoki, K & Sugano, H 2005, 'Familial aggregation and coaggregation of history of hypertension and stroke', Journal of Human Hypertension, vol. 19, no. 2, pp. 119-125. https://doi.org/10.1038/sj.jhh.1001788

Familial aggregation and coaggregation of history of hypertension and stroke. / Kondo, T.; Toyoshima, H.; Tsuzuki, Y.; Hori, Y.; Yatsuya, Hiroshi; Tamakoshi, K.; Tamakoshi, A.; Ohno, Y.; Aoki, Kunio; Sugano, Haruo.

In: Journal of Human Hypertension, Vol. 19, No. 2, 01.02.2005, p. 119-125.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Familial aggregation and coaggregation of history of hypertension and stroke

AU - Kondo, T.

AU - Toyoshima, H.

AU - Tsuzuki, Y.

AU - Hori, Y.

AU - Yatsuya, Hiroshi

AU - Tamakoshi, K.

AU - Tamakoshi, A.

AU - Ohno, Y.

AU - Aoki, Kunio

AU - Sugano, Haruo

PY - 2005/2/1

Y1 - 2005/2/1

N2 - We attempted to evaluate familial aggregation and coaggregation of history of hypertension and stroke. Past and family history of hypertension and stroke for 83 089 probands and their relatives were obtained from a data set for the Japan Collaborative Cohort Study for Evaluation of Cancer Risk sponsored by the Ministry of Education (JACC Study), which was initiated from 1988 to 1990. First, evaluation was performed for familial aggregation of each of two disorders using ordinal logistic regression of the generalized estimation equations (GEE) to account for dependence of observations within families. Secondly, in order to evaluate the familial congregation of the history of hypertension and stroke, a GEE-based multivariate probed predictive model was applied. After adjusting for the proband's age, level of obesity, smoking status, drinking status, habitation area, and the gender and type of the relatives, the estimated odds ratios for the intraindividual clustering and familial aggregation of the disease history showed statistically significant relationships. In addition, the history of the two disorders showed a significant relationship in terms of familial coaggregation independently of the aggregation of each disorder itself. Our results confirmed that hypertension and stroke coaggregate strongly within families through possible effects of genetic factors, which, alone or in conjunction with environmental factors, influence susceptibility to both hypertension and stroke.

AB - We attempted to evaluate familial aggregation and coaggregation of history of hypertension and stroke. Past and family history of hypertension and stroke for 83 089 probands and their relatives were obtained from a data set for the Japan Collaborative Cohort Study for Evaluation of Cancer Risk sponsored by the Ministry of Education (JACC Study), which was initiated from 1988 to 1990. First, evaluation was performed for familial aggregation of each of two disorders using ordinal logistic regression of the generalized estimation equations (GEE) to account for dependence of observations within families. Secondly, in order to evaluate the familial congregation of the history of hypertension and stroke, a GEE-based multivariate probed predictive model was applied. After adjusting for the proband's age, level of obesity, smoking status, drinking status, habitation area, and the gender and type of the relatives, the estimated odds ratios for the intraindividual clustering and familial aggregation of the disease history showed statistically significant relationships. In addition, the history of the two disorders showed a significant relationship in terms of familial coaggregation independently of the aggregation of each disorder itself. Our results confirmed that hypertension and stroke coaggregate strongly within families through possible effects of genetic factors, which, alone or in conjunction with environmental factors, influence susceptibility to both hypertension and stroke.

UR - http://www.scopus.com/inward/record.url?scp=13544276528&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=13544276528&partnerID=8YFLogxK

U2 - 10.1038/sj.jhh.1001788

DO - 10.1038/sj.jhh.1001788

M3 - Article

VL - 19

SP - 119

EP - 125

JO - Journal of Human Hypertension

JF - Journal of Human Hypertension

SN - 0950-9240

IS - 2

ER -