Family history and the risk of stomach cancer death in Japan: Differences by age and gender

Hiroshi Yatsuya, Hideaki Toyoshima, Tetsuya Mizoue, Takaaki Kondo, Koji Tamakoshi, Yoko Hori, Noritaka Tokui, Yoshiharu Hoshiyama, Shogo Kikuchi, Kiyomi Sakata, Norihiko Hayakawa, Akiko Tamakoshi, Yoshiyuki Ohno, Takesumi Yoshimura

Research output: Contribution to journalArticle

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Abstract

Familial aggregation of stomach cancer has long been observed. The effect on disease risk of family history and its magnitude according to the type of affected relatives, however, is not well known. We conducted a prospective analysis using the JACC study (Japan Collaborative Cohort Study For Evaluation of Cancer Risk, sponsored by Monbusho) data. During the follow-up period, 662 stomach cancer deaths were documented. A positive history of stomach cancer in one or more first-degree relatives was associated with a significantly increased risk of death from the disease in both men (RR 1.60; 95% CI 1.11-2.31) and women (RR 2.47; 95% CI 1.50-4.06). In the subanalysis stratified by age, the association between positive family history and stomach cancer was stronger in the age group from 40-59 (RR 2.62; 95% CI 1.34-5.11 for men and RR 5.88; 95% CI 2.70-12.82 for women) than in the age group from 60-79 (RR 1.31; 95% CI 0.84-2.05 for men and RR 1.44; 95% CI 0.72-2.88 for women). In the age group from 40-59, men with father's history and women with mother's and sister's history of the disease had a significantly increased risk (RR 3.14; 95% CI 1.51-6.55, RR 10.46; 95% CI 4.54-24.12, RR 13.39; 95% CI 3.89-46.12, respectively). When 2 or more family members were affected, the increment in the risk was prominent especially in women (RR 9.45; 95% CI 4.46-20.05). These results suggest the existence of a certain subtype of stomach cancer that is inherited more often by women from one generation to the next in gender-influenced fashion. Any preventive strategy should take into account the degree of individual susceptibility.

Original languageEnglish
Pages (from-to)688-694
Number of pages7
JournalInternational Journal of Cancer
Volume97
Issue number5
DOIs
Publication statusPublished - 10-02-2002

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Stomach Neoplasms
Japan
Age Groups
Fathers
Siblings
Cohort Studies
Mothers
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Yatsuya, H., Toyoshima, H., Mizoue, T., Kondo, T., Tamakoshi, K., Hori, Y., ... Yoshimura, T. (2002). Family history and the risk of stomach cancer death in Japan: Differences by age and gender. International Journal of Cancer, 97(5), 688-694. https://doi.org/10.1002/ijc.10101
Yatsuya, Hiroshi ; Toyoshima, Hideaki ; Mizoue, Tetsuya ; Kondo, Takaaki ; Tamakoshi, Koji ; Hori, Yoko ; Tokui, Noritaka ; Hoshiyama, Yoshiharu ; Kikuchi, Shogo ; Sakata, Kiyomi ; Hayakawa, Norihiko ; Tamakoshi, Akiko ; Ohno, Yoshiyuki ; Yoshimura, Takesumi. / Family history and the risk of stomach cancer death in Japan : Differences by age and gender. In: International Journal of Cancer. 2002 ; Vol. 97, No. 5. pp. 688-694.
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abstract = "Familial aggregation of stomach cancer has long been observed. The effect on disease risk of family history and its magnitude according to the type of affected relatives, however, is not well known. We conducted a prospective analysis using the JACC study (Japan Collaborative Cohort Study For Evaluation of Cancer Risk, sponsored by Monbusho) data. During the follow-up period, 662 stomach cancer deaths were documented. A positive history of stomach cancer in one or more first-degree relatives was associated with a significantly increased risk of death from the disease in both men (RR 1.60; 95{\%} CI 1.11-2.31) and women (RR 2.47; 95{\%} CI 1.50-4.06). In the subanalysis stratified by age, the association between positive family history and stomach cancer was stronger in the age group from 40-59 (RR 2.62; 95{\%} CI 1.34-5.11 for men and RR 5.88; 95{\%} CI 2.70-12.82 for women) than in the age group from 60-79 (RR 1.31; 95{\%} CI 0.84-2.05 for men and RR 1.44; 95{\%} CI 0.72-2.88 for women). In the age group from 40-59, men with father's history and women with mother's and sister's history of the disease had a significantly increased risk (RR 3.14; 95{\%} CI 1.51-6.55, RR 10.46; 95{\%} CI 4.54-24.12, RR 13.39; 95{\%} CI 3.89-46.12, respectively). When 2 or more family members were affected, the increment in the risk was prominent especially in women (RR 9.45; 95{\%} CI 4.46-20.05). These results suggest the existence of a certain subtype of stomach cancer that is inherited more often by women from one generation to the next in gender-influenced fashion. Any preventive strategy should take into account the degree of individual susceptibility.",
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Yatsuya, H, Toyoshima, H, Mizoue, T, Kondo, T, Tamakoshi, K, Hori, Y, Tokui, N, Hoshiyama, Y, Kikuchi, S, Sakata, K, Hayakawa, N, Tamakoshi, A, Ohno, Y & Yoshimura, T 2002, 'Family history and the risk of stomach cancer death in Japan: Differences by age and gender', International Journal of Cancer, vol. 97, no. 5, pp. 688-694. https://doi.org/10.1002/ijc.10101

Family history and the risk of stomach cancer death in Japan : Differences by age and gender. / Yatsuya, Hiroshi; Toyoshima, Hideaki; Mizoue, Tetsuya; Kondo, Takaaki; Tamakoshi, Koji; Hori, Yoko; Tokui, Noritaka; Hoshiyama, Yoshiharu; Kikuchi, Shogo; Sakata, Kiyomi; Hayakawa, Norihiko; Tamakoshi, Akiko; Ohno, Yoshiyuki; Yoshimura, Takesumi.

In: International Journal of Cancer, Vol. 97, No. 5, 10.02.2002, p. 688-694.

Research output: Contribution to journalArticle

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T1 - Family history and the risk of stomach cancer death in Japan

T2 - Differences by age and gender

AU - Yatsuya, Hiroshi

AU - Toyoshima, Hideaki

AU - Mizoue, Tetsuya

AU - Kondo, Takaaki

AU - Tamakoshi, Koji

AU - Hori, Yoko

AU - Tokui, Noritaka

AU - Hoshiyama, Yoshiharu

AU - Kikuchi, Shogo

AU - Sakata, Kiyomi

AU - Hayakawa, Norihiko

AU - Tamakoshi, Akiko

AU - Ohno, Yoshiyuki

AU - Yoshimura, Takesumi

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N2 - Familial aggregation of stomach cancer has long been observed. The effect on disease risk of family history and its magnitude according to the type of affected relatives, however, is not well known. We conducted a prospective analysis using the JACC study (Japan Collaborative Cohort Study For Evaluation of Cancer Risk, sponsored by Monbusho) data. During the follow-up period, 662 stomach cancer deaths were documented. A positive history of stomach cancer in one or more first-degree relatives was associated with a significantly increased risk of death from the disease in both men (RR 1.60; 95% CI 1.11-2.31) and women (RR 2.47; 95% CI 1.50-4.06). In the subanalysis stratified by age, the association between positive family history and stomach cancer was stronger in the age group from 40-59 (RR 2.62; 95% CI 1.34-5.11 for men and RR 5.88; 95% CI 2.70-12.82 for women) than in the age group from 60-79 (RR 1.31; 95% CI 0.84-2.05 for men and RR 1.44; 95% CI 0.72-2.88 for women). In the age group from 40-59, men with father's history and women with mother's and sister's history of the disease had a significantly increased risk (RR 3.14; 95% CI 1.51-6.55, RR 10.46; 95% CI 4.54-24.12, RR 13.39; 95% CI 3.89-46.12, respectively). When 2 or more family members were affected, the increment in the risk was prominent especially in women (RR 9.45; 95% CI 4.46-20.05). These results suggest the existence of a certain subtype of stomach cancer that is inherited more often by women from one generation to the next in gender-influenced fashion. Any preventive strategy should take into account the degree of individual susceptibility.

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