Fas antigen mRNA induction in postischemic murine brain

Tomohiro Matsuyama, Ryuji Hata, Masafumi Tagaya, Yoshihiro Yamamoto, Taisuke Nakajima, Jun ichi Furuyama, Akio Wanaka, Minoru Sugita

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Abstract

Fas antigen mRNA induction in the brain was examined using a transient global cerebral ischemia model in BALB/C mice. Northern blot analysis revealed little Fas antigen mRNA expression in the brains of sham-operated mice. A marked induction of Fas mRNA expression was detected in the brains of mice 6 h after 30 min of cerebral ischemia. These results suggest a possible apoptotic mechanism for cell death, mediated by the Fas antigen, in postischemic brain.

Original languageEnglish
Pages (from-to)342-346
Number of pages5
JournalBrain Research
Volume657
Issue number1-2
DOIs
Publication statusPublished - 19-09-1994

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All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Matsuyama, T., Hata, R., Tagaya, M., Yamamoto, Y., Nakajima, T., Furuyama, J. I., Wanaka, A., & Sugita, M. (1994). Fas antigen mRNA induction in postischemic murine brain. Brain Research, 657(1-2), 342-346. https://doi.org/10.1016/0006-8993(94)90989-X