Fasting plasma glucose cutoff for diagnosis of diabetes in a Japanese population

Yasufumi Doi, Michiaki Kubo, Koji Yonemoto, Toshiharu Ninomiya, Masanori Iwase, Hisatomi Arima, Jun Hata, Yumihiro Tanizaki, Mitsuo Iida, Yutaka Kiyohara

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Abstract

Objective: We examined the relationship between fasting plasma glucose (FPG) and 2-h post-load glucose (PG) levels, and the optimal FPG cutoff level to correspond to a 2-h PG of 11.1 mmol/liter, the gold standard diagnostic criterion, in a general Japanese population. Design: Cross-sectional study populations of 2421 subjects in 1988 and 2698 subjects in 2002, aged 40-79 yr and without antidiabetic medication, were tested with an oral glucose tolerance test. The relationship between FPG and 2-h PG was investigated by various regression models and a receiver operating characteristic curve. Results: The best-fit model for the relationship between FPG and 2-h PG was a quadratic regression model. The FPG cutoff levels corresponding to the 2-h PG of 11.1 mmol/liter by this model were 6.2 mmol/liter in 1988 and 6.3 mmol/liter in 2002. In the combined populations, the FPG cutoff point was 6.3 mmol/liter; the sensitivity and specificity of this cutoff point for detecting a 2-h PG of 11.1 mmol/liter were 75.2 and 88.6%, respectively. The receiver operating characteristic curve analysis confirmed that the corresponding FPG point was 6.2 mmol/liter in both the 1988 and 2002 populations. In a stratified analysis, the FPG cutoff level increased with increasing body mass index levels; however, even in subjects with body mass index more than or equal to 30 kg/m2, the FPG cutoff level was lower than 7.0 mmol/liter. Conclusions: Our findings suggest that the FPG cutoff level corresponding to the 2-h PG of 11.1 mmol/liter in the general Japanese population is lower than the current diagnostic criterion.

Original languageEnglish
Pages (from-to)3425-3429
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume93
Issue number9
DOIs
Publication statusPublished - 09-2008

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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    Doi, Y., Kubo, M., Yonemoto, K., Ninomiya, T., Iwase, M., Arima, H., Hata, J., Tanizaki, Y., Iida, M., & Kiyohara, Y. (2008). Fasting plasma glucose cutoff for diagnosis of diabetes in a Japanese population. Journal of Clinical Endocrinology and Metabolism, 93(9), 3425-3429. https://doi.org/10.1210/jc.2007-2819