Fasting plasma glucose cutoff for diagnosis of diabetes in a Japanese population

Yasufumi Doi, Michiaki Kubo, Koji Yonemoto, Toshiharu Ninomiya, Masanori Iwase, Hisatomi Arima, Jun Hata, Yumihiro Tanizaki, Mitsuo Iida, Yutaka Kiyohara

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective: We examined the relationship between fasting plasma glucose (FPG) and 2-h post-load glucose (PG) levels, and the optimal FPG cutoff level to correspond to a 2-h PG of 11.1 mmol/liter, the gold standard diagnostic criterion, in a general Japanese population. Design: Cross-sectional study populations of 2421 subjects in 1988 and 2698 subjects in 2002, aged 40-79 yr and without antidiabetic medication, were tested with an oral glucose tolerance test. The relationship between FPG and 2-h PG was investigated by various regression models and a receiver operating characteristic curve. Results: The best-fit model for the relationship between FPG and 2-h PG was a quadratic regression model. The FPG cutoff levels corresponding to the 2-h PG of 11.1 mmol/liter by this model were 6.2 mmol/liter in 1988 and 6.3 mmol/liter in 2002. In the combined populations, the FPG cutoff point was 6.3 mmol/liter; the sensitivity and specificity of this cutoff point for detecting a 2-h PG of 11.1 mmol/liter were 75.2 and 88.6%, respectively. The receiver operating characteristic curve analysis confirmed that the corresponding FPG point was 6.2 mmol/liter in both the 1988 and 2002 populations. In a stratified analysis, the FPG cutoff level increased with increasing body mass index levels; however, even in subjects with body mass index more than or equal to 30 kg/m2, the FPG cutoff level was lower than 7.0 mmol/liter. Conclusions: Our findings suggest that the FPG cutoff level corresponding to the 2-h PG of 11.1 mmol/liter in the general Japanese population is lower than the current diagnostic criterion.

Original languageEnglish
Pages (from-to)3425-3429
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume93
Issue number9
DOIs
Publication statusPublished - 01-01-2008
Externally publishedYes

Fingerprint

Medical problems
Fasting
Plasmas
Glucose
Population
ROC Curve
Body Mass Index
Glucose Tolerance Test
Hypoglycemic Agents

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Doi, Yasufumi ; Kubo, Michiaki ; Yonemoto, Koji ; Ninomiya, Toshiharu ; Iwase, Masanori ; Arima, Hisatomi ; Hata, Jun ; Tanizaki, Yumihiro ; Iida, Mitsuo ; Kiyohara, Yutaka. / Fasting plasma glucose cutoff for diagnosis of diabetes in a Japanese population. In: Journal of Clinical Endocrinology and Metabolism. 2008 ; Vol. 93, No. 9. pp. 3425-3429.
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Doi, Y, Kubo, M, Yonemoto, K, Ninomiya, T, Iwase, M, Arima, H, Hata, J, Tanizaki, Y, Iida, M & Kiyohara, Y 2008, 'Fasting plasma glucose cutoff for diagnosis of diabetes in a Japanese population', Journal of Clinical Endocrinology and Metabolism, vol. 93, no. 9, pp. 3425-3429. https://doi.org/10.1210/jc.2007-2819

Fasting plasma glucose cutoff for diagnosis of diabetes in a Japanese population. / Doi, Yasufumi; Kubo, Michiaki; Yonemoto, Koji; Ninomiya, Toshiharu; Iwase, Masanori; Arima, Hisatomi; Hata, Jun; Tanizaki, Yumihiro; Iida, Mitsuo; Kiyohara, Yutaka.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 93, No. 9, 01.01.2008, p. 3425-3429.

Research output: Contribution to journalArticle

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T1 - Fasting plasma glucose cutoff for diagnosis of diabetes in a Japanese population

AU - Doi, Yasufumi

AU - Kubo, Michiaki

AU - Yonemoto, Koji

AU - Ninomiya, Toshiharu

AU - Iwase, Masanori

AU - Arima, Hisatomi

AU - Hata, Jun

AU - Tanizaki, Yumihiro

AU - Iida, Mitsuo

AU - Kiyohara, Yutaka

PY - 2008/1/1

Y1 - 2008/1/1

N2 - Objective: We examined the relationship between fasting plasma glucose (FPG) and 2-h post-load glucose (PG) levels, and the optimal FPG cutoff level to correspond to a 2-h PG of 11.1 mmol/liter, the gold standard diagnostic criterion, in a general Japanese population. Design: Cross-sectional study populations of 2421 subjects in 1988 and 2698 subjects in 2002, aged 40-79 yr and without antidiabetic medication, were tested with an oral glucose tolerance test. The relationship between FPG and 2-h PG was investigated by various regression models and a receiver operating characteristic curve. Results: The best-fit model for the relationship between FPG and 2-h PG was a quadratic regression model. The FPG cutoff levels corresponding to the 2-h PG of 11.1 mmol/liter by this model were 6.2 mmol/liter in 1988 and 6.3 mmol/liter in 2002. In the combined populations, the FPG cutoff point was 6.3 mmol/liter; the sensitivity and specificity of this cutoff point for detecting a 2-h PG of 11.1 mmol/liter were 75.2 and 88.6%, respectively. The receiver operating characteristic curve analysis confirmed that the corresponding FPG point was 6.2 mmol/liter in both the 1988 and 2002 populations. In a stratified analysis, the FPG cutoff level increased with increasing body mass index levels; however, even in subjects with body mass index more than or equal to 30 kg/m2, the FPG cutoff level was lower than 7.0 mmol/liter. Conclusions: Our findings suggest that the FPG cutoff level corresponding to the 2-h PG of 11.1 mmol/liter in the general Japanese population is lower than the current diagnostic criterion.

AB - Objective: We examined the relationship between fasting plasma glucose (FPG) and 2-h post-load glucose (PG) levels, and the optimal FPG cutoff level to correspond to a 2-h PG of 11.1 mmol/liter, the gold standard diagnostic criterion, in a general Japanese population. Design: Cross-sectional study populations of 2421 subjects in 1988 and 2698 subjects in 2002, aged 40-79 yr and without antidiabetic medication, were tested with an oral glucose tolerance test. The relationship between FPG and 2-h PG was investigated by various regression models and a receiver operating characteristic curve. Results: The best-fit model for the relationship between FPG and 2-h PG was a quadratic regression model. The FPG cutoff levels corresponding to the 2-h PG of 11.1 mmol/liter by this model were 6.2 mmol/liter in 1988 and 6.3 mmol/liter in 2002. In the combined populations, the FPG cutoff point was 6.3 mmol/liter; the sensitivity and specificity of this cutoff point for detecting a 2-h PG of 11.1 mmol/liter were 75.2 and 88.6%, respectively. The receiver operating characteristic curve analysis confirmed that the corresponding FPG point was 6.2 mmol/liter in both the 1988 and 2002 populations. In a stratified analysis, the FPG cutoff level increased with increasing body mass index levels; however, even in subjects with body mass index more than or equal to 30 kg/m2, the FPG cutoff level was lower than 7.0 mmol/liter. Conclusions: Our findings suggest that the FPG cutoff level corresponding to the 2-h PG of 11.1 mmol/liter in the general Japanese population is lower than the current diagnostic criterion.

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DO - 10.1210/jc.2007-2819

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