TY - JOUR
T1 - Fasting serum apolipoprotein B-48 can be a marker of postprandial hyperlipidemia
AU - Masuda, Daisaku
AU - Sakai, Naohiko
AU - Sugimoto, Taizo
AU - Kitazume-Taneike, Rika
AU - Yamashita, Taiji
AU - Kawase, Ryota
AU - Nakaoka, Hajime
AU - Inagaki, Miwako
AU - Nakatani, Kazuhiro
AU - Yuasa-Kawase, Miyako
AU - Tsubakio-Yamamoto, Kazumi
AU - Ohama, Tohru
AU - Nakagawa-Toyama, Yumiko
AU - Nishida, Makoto
AU - Ishigami, Masato
AU - Masuda, Yoshiro
AU - Matsuyama, Akifumi
AU - Komuro, Issei
AU - Yamashita, Shizuya
PY - 2011/12/22
Y1 - 2011/12/22
N2 - Aim: Postprandial hyperlipidemia (PH) is thought to be caused by the impaired postprandial metabolism of triglycerides (TG)-rich lipoproteins in both endogenous and exogenous pathways; however, there is no consensus. It is difficult to estimate the presence of PH without performing a time-consuming oral fat loading (OFL) test, so postprandial lipoprotein metabolism was analyzed by measuring the postprandial levels of apolipoprotein (apo) B-48 and apo B-100, and the correlation between postprandial TG increase and fasting apoB-48 levels was assessed to establish a good marker of PH without performing an OFL test. Methods: Ten male normolipidemic subjects were loaded with a high-fat (HF, 1045 kcal) or standard (ST, 566 kcal) meal, and the lipids, apolipoproteins and lipoprotein profiles were analyzed after each meal. Results: TG, apo B-48, remnant-like particles (RLP)-cholesterol and RLP-TG levels were increased and their levels were significantly higher after intake of the HF meal than the ST meal; however, there was no postprandial increase in apo B-100 and LDL-C levels. Postprandial increases in TG levels of CM, VLDL, LDL and HDL were significantly higher after intake of the HF meal than the ST meal. Fasting apo B-48 levels were strongly correlated with the incremental area under the curve of TG after intake of the HF meal, but not the ST meal. Conclusion: Postprandial TG increase was mainly due to increased CM and CM-R, but not VLDL. Measurement of fasting serum apo B-48 may be a simple and useful method for assessment of the existence of PH.
AB - Aim: Postprandial hyperlipidemia (PH) is thought to be caused by the impaired postprandial metabolism of triglycerides (TG)-rich lipoproteins in both endogenous and exogenous pathways; however, there is no consensus. It is difficult to estimate the presence of PH without performing a time-consuming oral fat loading (OFL) test, so postprandial lipoprotein metabolism was analyzed by measuring the postprandial levels of apolipoprotein (apo) B-48 and apo B-100, and the correlation between postprandial TG increase and fasting apoB-48 levels was assessed to establish a good marker of PH without performing an OFL test. Methods: Ten male normolipidemic subjects were loaded with a high-fat (HF, 1045 kcal) or standard (ST, 566 kcal) meal, and the lipids, apolipoproteins and lipoprotein profiles were analyzed after each meal. Results: TG, apo B-48, remnant-like particles (RLP)-cholesterol and RLP-TG levels were increased and their levels were significantly higher after intake of the HF meal than the ST meal; however, there was no postprandial increase in apo B-100 and LDL-C levels. Postprandial increases in TG levels of CM, VLDL, LDL and HDL were significantly higher after intake of the HF meal than the ST meal. Fasting apo B-48 levels were strongly correlated with the incremental area under the curve of TG after intake of the HF meal, but not the ST meal. Conclusion: Postprandial TG increase was mainly due to increased CM and CM-R, but not VLDL. Measurement of fasting serum apo B-48 may be a simple and useful method for assessment of the existence of PH.
UR - http://www.scopus.com/inward/record.url?scp=84455211574&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84455211574&partnerID=8YFLogxK
U2 - 10.5551/jat.10470
DO - 10.5551/jat.10470
M3 - Article
C2 - 21946533
AN - SCOPUS:84455211574
SN - 1340-3478
VL - 18
SP - 1062
EP - 1070
JO - Journal of atherosclerosis and thrombosis
JF - Journal of atherosclerosis and thrombosis
IS - 12
ER -