Fasting serum apolipoprotein B-48 can be a marker of postprandial hyperlipidemia

Daisaku Masuda, Naohiko Sakai, Taizo Sugimoto, Rika Kitazume-Taneike, Taiji Yamashita, Ryota Kawase, Hajime Nakaoka, Miwako Inagaki, Kazuhiro Nakatani, Miyako Yuasa-Kawase, Kazumi Tsubakio-Yamamoto, Tohru Ohama, Yumiko Nakagawa-Toyama, Makoto Nishida, Masato Ishigami, Yoshiro Masuda, Akifumi Matsuyama, Issei Komuro, Shizuya Yamashita

Research output: Contribution to journalArticle

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Abstract

Aim: Postprandial hyperlipidemia (PH) is thought to be caused by the impaired postprandial metabolism of triglycerides (TG)-rich lipoproteins in both endogenous and exogenous pathways; however, there is no consensus. It is difficult to estimate the presence of PH without performing a time-consuming oral fat loading (OFL) test, so postprandial lipoprotein metabolism was analyzed by measuring the postprandial levels of apolipoprotein (apo) B-48 and apo B-100, and the correlation between postprandial TG increase and fasting apoB-48 levels was assessed to establish a good marker of PH without performing an OFL test. Methods: Ten male normolipidemic subjects were loaded with a high-fat (HF, 1045 kcal) or standard (ST, 566 kcal) meal, and the lipids, apolipoproteins and lipoprotein profiles were analyzed after each meal. Results: TG, apo B-48, remnant-like particles (RLP)-cholesterol and RLP-TG levels were increased and their levels were significantly higher after intake of the HF meal than the ST meal; however, there was no postprandial increase in apo B-100 and LDL-C levels. Postprandial increases in TG levels of CM, VLDL, LDL and HDL were significantly higher after intake of the HF meal than the ST meal. Fasting apo B-48 levels were strongly correlated with the incremental area under the curve of TG after intake of the HF meal, but not the ST meal. Conclusion: Postprandial TG increase was mainly due to increased CM and CM-R, but not VLDL. Measurement of fasting serum apo B-48 may be a simple and useful method for assessment of the existence of PH.

Original languageEnglish
Pages (from-to)1062-1070
Number of pages9
JournalJournal of atherosclerosis and thrombosis
Volume18
Issue number12
DOIs
Publication statusPublished - 22-12-2011

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Apolipoprotein B-48
Hyperlipidemias
Meals
Fasting
Triglycerides
Serum
Apolipoprotein B-100
Lipoproteins
Fats
Metabolism
Apolipoproteins
Area Under Curve
Consensus
Lipids

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine
  • Biochemistry, medical

Cite this

Masuda, D., Sakai, N., Sugimoto, T., Kitazume-Taneike, R., Yamashita, T., Kawase, R., ... Yamashita, S. (2011). Fasting serum apolipoprotein B-48 can be a marker of postprandial hyperlipidemia. Journal of atherosclerosis and thrombosis, 18(12), 1062-1070. https://doi.org/10.5551/jat.10470
Masuda, Daisaku ; Sakai, Naohiko ; Sugimoto, Taizo ; Kitazume-Taneike, Rika ; Yamashita, Taiji ; Kawase, Ryota ; Nakaoka, Hajime ; Inagaki, Miwako ; Nakatani, Kazuhiro ; Yuasa-Kawase, Miyako ; Tsubakio-Yamamoto, Kazumi ; Ohama, Tohru ; Nakagawa-Toyama, Yumiko ; Nishida, Makoto ; Ishigami, Masato ; Masuda, Yoshiro ; Matsuyama, Akifumi ; Komuro, Issei ; Yamashita, Shizuya. / Fasting serum apolipoprotein B-48 can be a marker of postprandial hyperlipidemia. In: Journal of atherosclerosis and thrombosis. 2011 ; Vol. 18, No. 12. pp. 1062-1070.
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abstract = "Aim: Postprandial hyperlipidemia (PH) is thought to be caused by the impaired postprandial metabolism of triglycerides (TG)-rich lipoproteins in both endogenous and exogenous pathways; however, there is no consensus. It is difficult to estimate the presence of PH without performing a time-consuming oral fat loading (OFL) test, so postprandial lipoprotein metabolism was analyzed by measuring the postprandial levels of apolipoprotein (apo) B-48 and apo B-100, and the correlation between postprandial TG increase and fasting apoB-48 levels was assessed to establish a good marker of PH without performing an OFL test. Methods: Ten male normolipidemic subjects were loaded with a high-fat (HF, 1045 kcal) or standard (ST, 566 kcal) meal, and the lipids, apolipoproteins and lipoprotein profiles were analyzed after each meal. Results: TG, apo B-48, remnant-like particles (RLP)-cholesterol and RLP-TG levels were increased and their levels were significantly higher after intake of the HF meal than the ST meal; however, there was no postprandial increase in apo B-100 and LDL-C levels. Postprandial increases in TG levels of CM, VLDL, LDL and HDL were significantly higher after intake of the HF meal than the ST meal. Fasting apo B-48 levels were strongly correlated with the incremental area under the curve of TG after intake of the HF meal, but not the ST meal. Conclusion: Postprandial TG increase was mainly due to increased CM and CM-R, but not VLDL. Measurement of fasting serum apo B-48 may be a simple and useful method for assessment of the existence of PH.",
author = "Daisaku Masuda and Naohiko Sakai and Taizo Sugimoto and Rika Kitazume-Taneike and Taiji Yamashita and Ryota Kawase and Hajime Nakaoka and Miwako Inagaki and Kazuhiro Nakatani and Miyako Yuasa-Kawase and Kazumi Tsubakio-Yamamoto and Tohru Ohama and Yumiko Nakagawa-Toyama and Makoto Nishida and Masato Ishigami and Yoshiro Masuda and Akifumi Matsuyama and Issei Komuro and Shizuya Yamashita",
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Masuda, D, Sakai, N, Sugimoto, T, Kitazume-Taneike, R, Yamashita, T, Kawase, R, Nakaoka, H, Inagaki, M, Nakatani, K, Yuasa-Kawase, M, Tsubakio-Yamamoto, K, Ohama, T, Nakagawa-Toyama, Y, Nishida, M, Ishigami, M, Masuda, Y, Matsuyama, A, Komuro, I & Yamashita, S 2011, 'Fasting serum apolipoprotein B-48 can be a marker of postprandial hyperlipidemia', Journal of atherosclerosis and thrombosis, vol. 18, no. 12, pp. 1062-1070. https://doi.org/10.5551/jat.10470

Fasting serum apolipoprotein B-48 can be a marker of postprandial hyperlipidemia. / Masuda, Daisaku; Sakai, Naohiko; Sugimoto, Taizo; Kitazume-Taneike, Rika; Yamashita, Taiji; Kawase, Ryota; Nakaoka, Hajime; Inagaki, Miwako; Nakatani, Kazuhiro; Yuasa-Kawase, Miyako; Tsubakio-Yamamoto, Kazumi; Ohama, Tohru; Nakagawa-Toyama, Yumiko; Nishida, Makoto; Ishigami, Masato; Masuda, Yoshiro; Matsuyama, Akifumi; Komuro, Issei; Yamashita, Shizuya.

In: Journal of atherosclerosis and thrombosis, Vol. 18, No. 12, 22.12.2011, p. 1062-1070.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Fasting serum apolipoprotein B-48 can be a marker of postprandial hyperlipidemia

AU - Masuda, Daisaku

AU - Sakai, Naohiko

AU - Sugimoto, Taizo

AU - Kitazume-Taneike, Rika

AU - Yamashita, Taiji

AU - Kawase, Ryota

AU - Nakaoka, Hajime

AU - Inagaki, Miwako

AU - Nakatani, Kazuhiro

AU - Yuasa-Kawase, Miyako

AU - Tsubakio-Yamamoto, Kazumi

AU - Ohama, Tohru

AU - Nakagawa-Toyama, Yumiko

AU - Nishida, Makoto

AU - Ishigami, Masato

AU - Masuda, Yoshiro

AU - Matsuyama, Akifumi

AU - Komuro, Issei

AU - Yamashita, Shizuya

PY - 2011/12/22

Y1 - 2011/12/22

N2 - Aim: Postprandial hyperlipidemia (PH) is thought to be caused by the impaired postprandial metabolism of triglycerides (TG)-rich lipoproteins in both endogenous and exogenous pathways; however, there is no consensus. It is difficult to estimate the presence of PH without performing a time-consuming oral fat loading (OFL) test, so postprandial lipoprotein metabolism was analyzed by measuring the postprandial levels of apolipoprotein (apo) B-48 and apo B-100, and the correlation between postprandial TG increase and fasting apoB-48 levels was assessed to establish a good marker of PH without performing an OFL test. Methods: Ten male normolipidemic subjects were loaded with a high-fat (HF, 1045 kcal) or standard (ST, 566 kcal) meal, and the lipids, apolipoproteins and lipoprotein profiles were analyzed after each meal. Results: TG, apo B-48, remnant-like particles (RLP)-cholesterol and RLP-TG levels were increased and their levels were significantly higher after intake of the HF meal than the ST meal; however, there was no postprandial increase in apo B-100 and LDL-C levels. Postprandial increases in TG levels of CM, VLDL, LDL and HDL were significantly higher after intake of the HF meal than the ST meal. Fasting apo B-48 levels were strongly correlated with the incremental area under the curve of TG after intake of the HF meal, but not the ST meal. Conclusion: Postprandial TG increase was mainly due to increased CM and CM-R, but not VLDL. Measurement of fasting serum apo B-48 may be a simple and useful method for assessment of the existence of PH.

AB - Aim: Postprandial hyperlipidemia (PH) is thought to be caused by the impaired postprandial metabolism of triglycerides (TG)-rich lipoproteins in both endogenous and exogenous pathways; however, there is no consensus. It is difficult to estimate the presence of PH without performing a time-consuming oral fat loading (OFL) test, so postprandial lipoprotein metabolism was analyzed by measuring the postprandial levels of apolipoprotein (apo) B-48 and apo B-100, and the correlation between postprandial TG increase and fasting apoB-48 levels was assessed to establish a good marker of PH without performing an OFL test. Methods: Ten male normolipidemic subjects were loaded with a high-fat (HF, 1045 kcal) or standard (ST, 566 kcal) meal, and the lipids, apolipoproteins and lipoprotein profiles were analyzed after each meal. Results: TG, apo B-48, remnant-like particles (RLP)-cholesterol and RLP-TG levels were increased and their levels were significantly higher after intake of the HF meal than the ST meal; however, there was no postprandial increase in apo B-100 and LDL-C levels. Postprandial increases in TG levels of CM, VLDL, LDL and HDL were significantly higher after intake of the HF meal than the ST meal. Fasting apo B-48 levels were strongly correlated with the incremental area under the curve of TG after intake of the HF meal, but not the ST meal. Conclusion: Postprandial TG increase was mainly due to increased CM and CM-R, but not VLDL. Measurement of fasting serum apo B-48 may be a simple and useful method for assessment of the existence of PH.

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DO - 10.5551/jat.10470

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Masuda D, Sakai N, Sugimoto T, Kitazume-Taneike R, Yamashita T, Kawase R et al. Fasting serum apolipoprotein B-48 can be a marker of postprandial hyperlipidemia. Journal of atherosclerosis and thrombosis. 2011 Dec 22;18(12):1062-1070. https://doi.org/10.5551/jat.10470