Fat and carbohydrate in western diet contribute differently to hepatic lipid accumulation

Wudelehu Wu; Hiromi Tsuchida; Takehiro Kato; Horoyuki Niwa; Yukio Horikawa; Jun Takeda; Katsumi Iizuka

doi:10.1016/j.bbrc.2015.04.092

Fat and carbohydrate in western diet contribute differently to hepatic lipid accumulation

Wudelehu Wu, Hiromi Tsuchida, Takehiro Kato, Horoyuki Niwa, Yukio Horikawa, Jun Takeda, Katsumi Iizuka

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

We investigated the contributions of dietary fat and dietary carbohydrate to the development of fatty liver induced by western diet (WD). Compared with WD-fed wild type (WT) mice, livers of WD-fed ChREBP^-/- mice showed lipid droplets of varying sizes around the hepatic lobules, while hepatic triglyceride and cholesterol contents were only modestly decreased. Inflammation and fibrosis were suppressed in ChREBP^-/- mice. In addition, compared with WD-fed WT mice, ChREBP^-/- mice showed decreased β-oxidation, ketogenesis and FGF21 production, increased intestinal lipid absorption, and decreased VLDL secretion. These findings suggest that dietary fat and carbohydrate contribute differently to the development of fatty liver.

Original language	English
Pages (from-to)	681-686
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	461
Issue number	4
DOIs	https://doi.org/10.1016/j.bbrc.2015.04.092
Publication status	Published - 12-06-2015
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.bbrc.2015.04.092

Cite this

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title = "Fat and carbohydrate in western diet contribute differently to hepatic lipid accumulation",

abstract = "We investigated the contributions of dietary fat and dietary carbohydrate to the development of fatty liver induced by western diet (WD). Compared with WD-fed wild type (WT) mice, livers of WD-fed ChREBP-/- mice showed lipid droplets of varying sizes around the hepatic lobules, while hepatic triglyceride and cholesterol contents were only modestly decreased. Inflammation and fibrosis were suppressed in ChREBP-/- mice. In addition, compared with WD-fed WT mice, ChREBP-/- mice showed decreased β-oxidation, ketogenesis and FGF21 production, increased intestinal lipid absorption, and decreased VLDL secretion. These findings suggest that dietary fat and carbohydrate contribute differently to the development of fatty liver.",

keywords = "ChREBP, FGF21, Hepatic steatosis, Ketogenesis, VLDL, β-oxidation",

author = "Wudelehu Wu and Hiromi Tsuchida and Takehiro Kato and Horoyuki Niwa and Yukio Horikawa and Jun Takeda and Katsumi Iizuka",

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T1 - Fat and carbohydrate in western diet contribute differently to hepatic lipid accumulation

AU - Wu, Wudelehu

AU - Tsuchida, Hiromi

AU - Kato, Takehiro

AU - Niwa, Horoyuki

AU - Horikawa, Yukio

AU - Takeda, Jun

AU - Iizuka, Katsumi

PY - 2015/6/12

Y1 - 2015/6/12

N2 - We investigated the contributions of dietary fat and dietary carbohydrate to the development of fatty liver induced by western diet (WD). Compared with WD-fed wild type (WT) mice, livers of WD-fed ChREBP-/- mice showed lipid droplets of varying sizes around the hepatic lobules, while hepatic triglyceride and cholesterol contents were only modestly decreased. Inflammation and fibrosis were suppressed in ChREBP-/- mice. In addition, compared with WD-fed WT mice, ChREBP-/- mice showed decreased β-oxidation, ketogenesis and FGF21 production, increased intestinal lipid absorption, and decreased VLDL secretion. These findings suggest that dietary fat and carbohydrate contribute differently to the development of fatty liver.

AB - We investigated the contributions of dietary fat and dietary carbohydrate to the development of fatty liver induced by western diet (WD). Compared with WD-fed wild type (WT) mice, livers of WD-fed ChREBP-/- mice showed lipid droplets of varying sizes around the hepatic lobules, while hepatic triglyceride and cholesterol contents were only modestly decreased. Inflammation and fibrosis were suppressed in ChREBP-/- mice. In addition, compared with WD-fed WT mice, ChREBP-/- mice showed decreased β-oxidation, ketogenesis and FGF21 production, increased intestinal lipid absorption, and decreased VLDL secretion. These findings suggest that dietary fat and carbohydrate contribute differently to the development of fatty liver.

KW - ChREBP

KW - FGF21

KW - Hepatic steatosis

KW - Ketogenesis

KW - VLDL

KW - β-oxidation

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JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 4

ER -

Fat and carbohydrate in western diet contribute differently to hepatic lipid accumulation

Abstract

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