Fat and carbohydrate in western diet contribute differently to hepatic lipid accumulation

Wudelehu Wu, Hiromi Tsuchida, Takehiro Kato, Horoyuki Niwa, Yukio Horikawa, Jun Takeda, Katsumi Iizuka

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)


We investigated the contributions of dietary fat and dietary carbohydrate to the development of fatty liver induced by western diet (WD). Compared with WD-fed wild type (WT) mice, livers of WD-fed ChREBP-/- mice showed lipid droplets of varying sizes around the hepatic lobules, while hepatic triglyceride and cholesterol contents were only modestly decreased. Inflammation and fibrosis were suppressed in ChREBP-/- mice. In addition, compared with WD-fed WT mice, ChREBP-/- mice showed decreased β-oxidation, ketogenesis and FGF21 production, increased intestinal lipid absorption, and decreased VLDL secretion. These findings suggest that dietary fat and carbohydrate contribute differently to the development of fatty liver.

Original languageEnglish
Pages (from-to)681-686
Number of pages6
JournalBiochemical and Biophysical Research Communications
Issue number4
Publication statusPublished - 12-06-2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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