Fatal acute myocarditis in an infant with human herpesvirus 6 infection

Tetsushi Yoshikawa, Masaru Ihira, K. Suzuki, S. Suga, H. Kito, T. Iwasaki, T. Kurata, T. Tanaka, Y. Saito, Y. Asano

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Abstract

A 5 month old girl had typical clinical features of acute myocarditis just after the febrile period of exanthem subitum and died immediately. She had been healthy, with normal development, and there was no family history of particular note. Myocardial postmortem findings were compatible with acute myocarditis. Although the isolation of human herpesvirus 6 (HHV-6) was not attempted, positive IgM antibody to HHV-6 was detected in the patient's serum. Moreover, HHV-6 variant B DNA was detected in several tissues, including myocardium, by the polymerase chain reaction (PCR). In contrast, antibody responses to human herpesvirus 7, another causal agent of exanthem subitum, were not found, and enteroviral RNA was not detected in myocardial tissues by reverse transcription PCR. Apoptotic changes were seen in infiltrating cells within the myocardial tissues by means of the TUNEL method. HHV-6 antigen was not detected in several tissues (including myocardium) by immunohistochemical analysis. In conclusion, HHV-6 may have been the causative agent of fatal acute myocarditis in this infant.

Original languageEnglish
Pages (from-to)792-795
Number of pages4
JournalJournal of Clinical Pathology
Volume54
Issue number10
DOIs
Publication statusPublished - 01-01-2001

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Human Herpesvirus 6
Herpesviridae Infections
Myocarditis
Exanthema
Myocardium
Human Herpesvirus 7
Polymerase Chain Reaction
In Situ Nick-End Labeling
Reverse Transcription
Antibody Formation
Immunoglobulin M
Fever
RNA
Antigens
Antibodies
DNA
Serum

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Yoshikawa, Tetsushi ; Ihira, Masaru ; Suzuki, K. ; Suga, S. ; Kito, H. ; Iwasaki, T. ; Kurata, T. ; Tanaka, T. ; Saito, Y. ; Asano, Y. / Fatal acute myocarditis in an infant with human herpesvirus 6 infection. In: Journal of Clinical Pathology. 2001 ; Vol. 54, No. 10. pp. 792-795.
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Yoshikawa, T, Ihira, M, Suzuki, K, Suga, S, Kito, H, Iwasaki, T, Kurata, T, Tanaka, T, Saito, Y & Asano, Y 2001, 'Fatal acute myocarditis in an infant with human herpesvirus 6 infection', Journal of Clinical Pathology, vol. 54, no. 10, pp. 792-795. https://doi.org/10.1136/jcp.54.10.792

Fatal acute myocarditis in an infant with human herpesvirus 6 infection. / Yoshikawa, Tetsushi; Ihira, Masaru; Suzuki, K.; Suga, S.; Kito, H.; Iwasaki, T.; Kurata, T.; Tanaka, T.; Saito, Y.; Asano, Y.

In: Journal of Clinical Pathology, Vol. 54, No. 10, 01.01.2001, p. 792-795.

Research output: Contribution to journalArticle

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AU - Yoshikawa, Tetsushi

AU - Ihira, Masaru

AU - Suzuki, K.

AU - Suga, S.

AU - Kito, H.

AU - Iwasaki, T.

AU - Kurata, T.

AU - Tanaka, T.

AU - Saito, Y.

AU - Asano, Y.

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N2 - A 5 month old girl had typical clinical features of acute myocarditis just after the febrile period of exanthem subitum and died immediately. She had been healthy, with normal development, and there was no family history of particular note. Myocardial postmortem findings were compatible with acute myocarditis. Although the isolation of human herpesvirus 6 (HHV-6) was not attempted, positive IgM antibody to HHV-6 was detected in the patient's serum. Moreover, HHV-6 variant B DNA was detected in several tissues, including myocardium, by the polymerase chain reaction (PCR). In contrast, antibody responses to human herpesvirus 7, another causal agent of exanthem subitum, were not found, and enteroviral RNA was not detected in myocardial tissues by reverse transcription PCR. Apoptotic changes were seen in infiltrating cells within the myocardial tissues by means of the TUNEL method. HHV-6 antigen was not detected in several tissues (including myocardium) by immunohistochemical analysis. In conclusion, HHV-6 may have been the causative agent of fatal acute myocarditis in this infant.

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