Fatal adult case of severe lymphocytopenia associated with reactivation of human herpesvirus 6

Tetsushi Yoshikawa, Masaru Ihira, Yoshizo Asano, Akiko Yagami, Kayoko Suzuki, Kayoko Matsunaga, Yasuchika Kato, Sinya Hiramitsu, Tomohito Nagai, Naoko Tanaka, Hiroshi Kimura, Yukihiro Nishiyama

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

It has been suggested that immunosuppression associated with human herpesvirus 6 (HHV-6) infection is a result of functional impairment or direct destruction of immunological cells. The ability of the virus to infect and destroy lymphocytes may cause progressive immunodeficiency in an infant with primary HHV-6 infection. An adult patient is described who had a fatal cytomegalovirus (CMV) infection due to severe and prolonged lymphocyte depletion associated with HHV-6 reactivation. The HHV-6 antibody titers were increased significantly after reactivation, and the virus was isolated from his peripheral blood mononuclear cells. The quantity of both HHV-6 and CMV DNA was determined by using real-time PCR in plasma samples collected serially. HHV-6 DNAemia persisted for 1 month, which started just 1 week after the onset of lymphocytopenia. In contrast to HHV-6, CMV DNAemia was detected in the terminal phase of the illness. Thus, HHV-6 reactivation may have been the cause of the severe lymphocyte depletion and fatal CMV infection.

Original languageEnglish
Pages (from-to)82-85
Number of pages4
JournalJournal of Medical Virology
Volume66
Issue number1
DOIs
Publication statusPublished - 11-03-2002

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Human Herpesvirus 6
Lymphopenia
Lymphocyte Depletion
Herpesviridae Infections
Cytomegalovirus Infections
Cytomegalovirus
Viruses
Immunosuppression
Real-Time Polymerase Chain Reaction
Blood Cells
Lymphocytes
Antibodies
DNA

All Science Journal Classification (ASJC) codes

  • Virology
  • Infectious Diseases

Cite this

Yoshikawa, Tetsushi ; Ihira, Masaru ; Asano, Yoshizo ; Yagami, Akiko ; Suzuki, Kayoko ; Matsunaga, Kayoko ; Kato, Yasuchika ; Hiramitsu, Sinya ; Nagai, Tomohito ; Tanaka, Naoko ; Kimura, Hiroshi ; Nishiyama, Yukihiro. / Fatal adult case of severe lymphocytopenia associated with reactivation of human herpesvirus 6. In: Journal of Medical Virology. 2002 ; Vol. 66, No. 1. pp. 82-85.
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author = "Tetsushi Yoshikawa and Masaru Ihira and Yoshizo Asano and Akiko Yagami and Kayoko Suzuki and Kayoko Matsunaga and Yasuchika Kato and Sinya Hiramitsu and Tomohito Nagai and Naoko Tanaka and Hiroshi Kimura and Yukihiro Nishiyama",
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Yoshikawa, T, Ihira, M, Asano, Y, Yagami, A, Suzuki, K, Matsunaga, K, Kato, Y, Hiramitsu, S, Nagai, T, Tanaka, N, Kimura, H & Nishiyama, Y 2002, 'Fatal adult case of severe lymphocytopenia associated with reactivation of human herpesvirus 6', Journal of Medical Virology, vol. 66, no. 1, pp. 82-85. https://doi.org/10.1002/jmv.2114

Fatal adult case of severe lymphocytopenia associated with reactivation of human herpesvirus 6. / Yoshikawa, Tetsushi; Ihira, Masaru; Asano, Yoshizo; Yagami, Akiko; Suzuki, Kayoko; Matsunaga, Kayoko; Kato, Yasuchika; Hiramitsu, Sinya; Nagai, Tomohito; Tanaka, Naoko; Kimura, Hiroshi; Nishiyama, Yukihiro.

In: Journal of Medical Virology, Vol. 66, No. 1, 11.03.2002, p. 82-85.

Research output: Contribution to journalArticle

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AU - Suzuki, Kayoko

AU - Matsunaga, Kayoko

AU - Kato, Yasuchika

AU - Hiramitsu, Sinya

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AU - Tanaka, Naoko

AU - Kimura, Hiroshi

AU - Nishiyama, Yukihiro

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N2 - It has been suggested that immunosuppression associated with human herpesvirus 6 (HHV-6) infection is a result of functional impairment or direct destruction of immunological cells. The ability of the virus to infect and destroy lymphocytes may cause progressive immunodeficiency in an infant with primary HHV-6 infection. An adult patient is described who had a fatal cytomegalovirus (CMV) infection due to severe and prolonged lymphocyte depletion associated with HHV-6 reactivation. The HHV-6 antibody titers were increased significantly after reactivation, and the virus was isolated from his peripheral blood mononuclear cells. The quantity of both HHV-6 and CMV DNA was determined by using real-time PCR in plasma samples collected serially. HHV-6 DNAemia persisted for 1 month, which started just 1 week after the onset of lymphocytopenia. In contrast to HHV-6, CMV DNAemia was detected in the terminal phase of the illness. Thus, HHV-6 reactivation may have been the cause of the severe lymphocyte depletion and fatal CMV infection.

AB - It has been suggested that immunosuppression associated with human herpesvirus 6 (HHV-6) infection is a result of functional impairment or direct destruction of immunological cells. The ability of the virus to infect and destroy lymphocytes may cause progressive immunodeficiency in an infant with primary HHV-6 infection. An adult patient is described who had a fatal cytomegalovirus (CMV) infection due to severe and prolonged lymphocyte depletion associated with HHV-6 reactivation. The HHV-6 antibody titers were increased significantly after reactivation, and the virus was isolated from his peripheral blood mononuclear cells. The quantity of both HHV-6 and CMV DNA was determined by using real-time PCR in plasma samples collected serially. HHV-6 DNAemia persisted for 1 month, which started just 1 week after the onset of lymphocytopenia. In contrast to HHV-6, CMV DNAemia was detected in the terminal phase of the illness. Thus, HHV-6 reactivation may have been the cause of the severe lymphocyte depletion and fatal CMV infection.

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