Fatal hemoptysis due to endobronchial aspergilloma in the hyperinflated native lung after single-lung transplantation for lymphangioleiomyomatosis: A case report

Asuka Yoshizaki, Masatsugu Yamamoto, Aya Hirabayashi, Yoshihiko Ono, Yukihisa Hatakeyama, Kyosuke Nakata, Daisuke Tamura, Motoko Tachihara, Hiroshi Kamiryo, Kazuyuki Kobayashi, Mari Nishio, Yoshihiro Nishimura

Research output: Contribution to journalArticlepeer-review

Abstract

Pulmonary lymphangioleiomyomatosis accounts for the majority of cadaveric lung transplantation cases. Post-transplantation management is continuingly necessary not only to prevent the progression of LAM but also to address complications. A woman with lymphangioleiomyomatosis underwent cadaveric lung transplantation. She developed post-operative native lung hyperinflation and hemoptysis with cavity shadow in the native lung on computed tomography. Isolated Aspergillus from her sputum and positive Aspergillus galactomannan antigen in the blood led to a diagnosis of aspergillosis. Despite the reduction of hemoptysis by antifungal medication, she developed fatal hemoptysis. An autopsy showed an Aspergillus fungal mass in the bronchus in the native lung whilst the lung graft was free from lymphangioleiomyomatosis lesions. Endobronchial aspergilloma was suggested to be a cause of hemoptysis. This fatal clinical course suggested that hemoptysis due to endobronchial aspergilloma in the native lung should have been considered native lung pneumonectomy as a further intervention.

Original languageEnglish
Pages (from-to)E114-E117
JournalKobe Journal of Medical Sciences
Volume65
Issue number4
Publication statusPublished - 2019
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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