Fate of neural stem cells grafted into injured inner ears of mice

Ichiro Tateya, Takayuki Nakagawa, Fukuichiro Iguchi, Tae Soo Kim, Tsuyoshi Endo, Shuichi Yamada, Ryoichiro Kageyama, Yasushi Naito, Juichi Ito

Research output: Contribution to journalArticlepeer-review

95 Citations (Scopus)

Abstract

Loss of sensory hair cells in the inner ear is a major cause of permanent hearing loss, since regeneration of hair cells rarely occurs in mammals. The aim of this study was to examine the potential of neural stem cell transplantation to restore inner ear hair cells in mice. Fetal neural stem cells were transplanted into the mouse inner ear after drug-induced injury. Histological analysis demonstrates that the majority of grafted cells differentiated into glial or neural cells in the inner ear. Strikingly, however, we show that grafted cells integrate in vestibular sensory epithelia and express specific markers for hair cells. This finding suggests that transplanted neural stem cells have the potential to differentiate and restore inner ear hair cells.

Original languageEnglish
Pages (from-to)1677-1681
Number of pages5
JournalNeuroreport
Volume14
Issue number13
DOIs
Publication statusPublished - 15-09-2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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