Fatty acid metabolism and myocardial perfusion imaging for the evaluation of global left ventricular dysfunction following acute myocardial infarction: Comparisons with echocardiography

Shankar Kumar Biswas, Masayoshi Sarai, Akira Yamada, Sadako Motoyama, Hiroto Harigaya, Tomonori Hara, Kunihiko Sugimoto, Hiroshi Toyama, Hitoshi Hishida, Yukio Ozaki

Research output: Contribution to journalArticle

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Abstract

Background: Myocardial fatty acid metabolic imaging with beta-methyl iodophenyl pentadecanoic acid (BMIPP) and perfusion imaging with tetrofosmin (TF) combined can predict post ischemic salvageable myocardium and persistent left ventricular (LV) dysfunction. This study was designed for the first time to assess systolic, diastolic and global LV dysfunction considering BMIPP and TF mismatched defect score (MMDS), and comparing this approach with the conventional Doppler echocardiography. Methods: Thirty four patients with first acute myocardial infarction (AMI) were enrolled, and all of them underwent percutaneous coronary intervention (PCI). BMIPP and Tetrofosmin (TF) scans were performed at 7 ± 3.5 days of admission. Echocardiography was performed within 24 h of admission, at an interval of 1 and 3 months. MMDS was compared with systolic: ejection fraction (EF), wall motion score index (WMSI), fractional shortening (FS); diastolic: mitral valve deceleration time (MVDT), E/E′, left atrial volume index (LAVI); combined systolic and diastolic parameter: left ventricular myocardial performance index (LVMPI). Results: A good correlation was observed between BMIPP and TF defect score (p < 0.00001), and in 31 (91%) patients BMIPP defect score was higher than that of TF. The MMDS showed significant correlation with EF (r = - 0.64, p = < 0.00001), WMSI (r = 0.61, p < 0.0001), and FS(r = - 0.65, p < 0.00001), LAVI (r = - 0.32, p < 0.05), and LVMPI (r = 0.37, p < 0.02) during follow up echocardiography at 1 month. MVDT and E/E′ did not correlate with MMDS. Conclusion: Perfusion-metabolism mismatched defect score was well correlated with the evolution of global left ventricular dysfunction following AMI evidenced from conventional Doppler echocardiography.

Original languageEnglish
Pages (from-to)290-299
Number of pages10
JournalInternational Journal of Cardiology
Volume138
Issue number3
DOIs
Publication statusPublished - 04-02-2010

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Myocardial Perfusion Imaging
Left Ventricular Dysfunction
Echocardiography
Fatty Acids
Myocardial Infarction
Deceleration
Doppler Echocardiography
Mitral Valve
Perfusion Imaging
Percutaneous Coronary Intervention
Myocardium
Perfusion
pentadecanoic acid

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

@article{d14bb22614c94d5cb5120671c5385b44,
title = "Fatty acid metabolism and myocardial perfusion imaging for the evaluation of global left ventricular dysfunction following acute myocardial infarction: Comparisons with echocardiography",
abstract = "Background: Myocardial fatty acid metabolic imaging with beta-methyl iodophenyl pentadecanoic acid (BMIPP) and perfusion imaging with tetrofosmin (TF) combined can predict post ischemic salvageable myocardium and persistent left ventricular (LV) dysfunction. This study was designed for the first time to assess systolic, diastolic and global LV dysfunction considering BMIPP and TF mismatched defect score (MMDS), and comparing this approach with the conventional Doppler echocardiography. Methods: Thirty four patients with first acute myocardial infarction (AMI) were enrolled, and all of them underwent percutaneous coronary intervention (PCI). BMIPP and Tetrofosmin (TF) scans were performed at 7 ± 3.5 days of admission. Echocardiography was performed within 24 h of admission, at an interval of 1 and 3 months. MMDS was compared with systolic: ejection fraction (EF), wall motion score index (WMSI), fractional shortening (FS); diastolic: mitral valve deceleration time (MVDT), E/E′, left atrial volume index (LAVI); combined systolic and diastolic parameter: left ventricular myocardial performance index (LVMPI). Results: A good correlation was observed between BMIPP and TF defect score (p < 0.00001), and in 31 (91{\%}) patients BMIPP defect score was higher than that of TF. The MMDS showed significant correlation with EF (r = - 0.64, p = < 0.00001), WMSI (r = 0.61, p < 0.0001), and FS(r = - 0.65, p < 0.00001), LAVI (r = - 0.32, p < 0.05), and LVMPI (r = 0.37, p < 0.02) during follow up echocardiography at 1 month. MVDT and E/E′ did not correlate with MMDS. Conclusion: Perfusion-metabolism mismatched defect score was well correlated with the evolution of global left ventricular dysfunction following AMI evidenced from conventional Doppler echocardiography.",
author = "Biswas, {Shankar Kumar} and Masayoshi Sarai and Akira Yamada and Sadako Motoyama and Hiroto Harigaya and Tomonori Hara and Kunihiko Sugimoto and Hiroshi Toyama and Hitoshi Hishida and Yukio Ozaki",
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Fatty acid metabolism and myocardial perfusion imaging for the evaluation of global left ventricular dysfunction following acute myocardial infarction : Comparisons with echocardiography. / Biswas, Shankar Kumar; Sarai, Masayoshi; Yamada, Akira; Motoyama, Sadako; Harigaya, Hiroto; Hara, Tomonori; Sugimoto, Kunihiko; Toyama, Hiroshi; Hishida, Hitoshi; Ozaki, Yukio.

In: International Journal of Cardiology, Vol. 138, No. 3, 04.02.2010, p. 290-299.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Fatty acid metabolism and myocardial perfusion imaging for the evaluation of global left ventricular dysfunction following acute myocardial infarction

T2 - Comparisons with echocardiography

AU - Biswas, Shankar Kumar

AU - Sarai, Masayoshi

AU - Yamada, Akira

AU - Motoyama, Sadako

AU - Harigaya, Hiroto

AU - Hara, Tomonori

AU - Sugimoto, Kunihiko

AU - Toyama, Hiroshi

AU - Hishida, Hitoshi

AU - Ozaki, Yukio

PY - 2010/2/4

Y1 - 2010/2/4

N2 - Background: Myocardial fatty acid metabolic imaging with beta-methyl iodophenyl pentadecanoic acid (BMIPP) and perfusion imaging with tetrofosmin (TF) combined can predict post ischemic salvageable myocardium and persistent left ventricular (LV) dysfunction. This study was designed for the first time to assess systolic, diastolic and global LV dysfunction considering BMIPP and TF mismatched defect score (MMDS), and comparing this approach with the conventional Doppler echocardiography. Methods: Thirty four patients with first acute myocardial infarction (AMI) were enrolled, and all of them underwent percutaneous coronary intervention (PCI). BMIPP and Tetrofosmin (TF) scans were performed at 7 ± 3.5 days of admission. Echocardiography was performed within 24 h of admission, at an interval of 1 and 3 months. MMDS was compared with systolic: ejection fraction (EF), wall motion score index (WMSI), fractional shortening (FS); diastolic: mitral valve deceleration time (MVDT), E/E′, left atrial volume index (LAVI); combined systolic and diastolic parameter: left ventricular myocardial performance index (LVMPI). Results: A good correlation was observed between BMIPP and TF defect score (p < 0.00001), and in 31 (91%) patients BMIPP defect score was higher than that of TF. The MMDS showed significant correlation with EF (r = - 0.64, p = < 0.00001), WMSI (r = 0.61, p < 0.0001), and FS(r = - 0.65, p < 0.00001), LAVI (r = - 0.32, p < 0.05), and LVMPI (r = 0.37, p < 0.02) during follow up echocardiography at 1 month. MVDT and E/E′ did not correlate with MMDS. Conclusion: Perfusion-metabolism mismatched defect score was well correlated with the evolution of global left ventricular dysfunction following AMI evidenced from conventional Doppler echocardiography.

AB - Background: Myocardial fatty acid metabolic imaging with beta-methyl iodophenyl pentadecanoic acid (BMIPP) and perfusion imaging with tetrofosmin (TF) combined can predict post ischemic salvageable myocardium and persistent left ventricular (LV) dysfunction. This study was designed for the first time to assess systolic, diastolic and global LV dysfunction considering BMIPP and TF mismatched defect score (MMDS), and comparing this approach with the conventional Doppler echocardiography. Methods: Thirty four patients with first acute myocardial infarction (AMI) were enrolled, and all of them underwent percutaneous coronary intervention (PCI). BMIPP and Tetrofosmin (TF) scans were performed at 7 ± 3.5 days of admission. Echocardiography was performed within 24 h of admission, at an interval of 1 and 3 months. MMDS was compared with systolic: ejection fraction (EF), wall motion score index (WMSI), fractional shortening (FS); diastolic: mitral valve deceleration time (MVDT), E/E′, left atrial volume index (LAVI); combined systolic and diastolic parameter: left ventricular myocardial performance index (LVMPI). Results: A good correlation was observed between BMIPP and TF defect score (p < 0.00001), and in 31 (91%) patients BMIPP defect score was higher than that of TF. The MMDS showed significant correlation with EF (r = - 0.64, p = < 0.00001), WMSI (r = 0.61, p < 0.0001), and FS(r = - 0.65, p < 0.00001), LAVI (r = - 0.32, p < 0.05), and LVMPI (r = 0.37, p < 0.02) during follow up echocardiography at 1 month. MVDT and E/E′ did not correlate with MMDS. Conclusion: Perfusion-metabolism mismatched defect score was well correlated with the evolution of global left ventricular dysfunction following AMI evidenced from conventional Doppler echocardiography.

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