Feasibility of sentinel node navigation surgery after noncurative endoscopic resection for early gastric cancer

Takaaki Arigami, Yoshikazu Uenosono, Shigehiro Yanagita, Daisuke Matsushita, Hideo Arima, Munetsugu Hirata, Yasuto Uchikado, Akihiro Nakajo, Hiroshi Okumura, Sumiya Ishigami, Shuichi Hokita, Shoji Natsugoe

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11 Citations (Scopus)

Abstract

Background and Aim: Recently, the use of additional surgery after noncurative endoscopic resection has gradually increased due to the rapid spread of endoscopic treatments in selected patients with early gastric cancer. Sentinel node navigation surgery (SNNS) has also been recognized as a minimally invasive surgery with personalized lymphadenectomy in early gastric cancer. Here, we assessed the feasibility of SNNS after noncurative endoscopic resection for early gastric cancer. Methods: Sixteen patients with early gastric cancer, in whom additional surgery had been indicated due to noncurative endoscopic resection, were enrolled. They underwent a gastrectomy with standard lymphadenectomy. One day before surgery, 99mtechnetium-tin colloid was endoscopically injected into the submucosa around the tumor. After surgery, the uptake of radioisotope in dissected lymph nodes was measured using Navigator GPS. Then, all dissected lymph nodes were investigated by hematoxylin-eosin staining and immunohistochemistry using an antihuman cytokeratin monoclonal antibody. Results: Hematoxylin-eosin staining demonstrated lymph node metastasis in two (12.5%) of 16 patients and in three (0.8%) of 382 nodes. However, immunohistochemistry showed that none of the patients had lymph node micrometastasis. Sentinel nodes (SNs) were identified in all patients. The mean number of SNs was 3.1 (range, 1-6). Among two patients with lymph node metastasis, the SNs, at least, contained positive nodes. Accordingly, the false-negative and accuracy rates were 0% and 100%, respectively. Conclusion: Our results indicate that SNNS may have potential as a further minimally invasive surgery in early gastric cancer patients after noncurative endoscopic resection.

Original languageEnglish
Pages (from-to)1343-1347
Number of pages5
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume28
Issue number8
DOIs
Publication statusPublished - 08-2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

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    Arigami, T., Uenosono, Y., Yanagita, S., Matsushita, D., Arima, H., Hirata, M., Uchikado, Y., Nakajo, A., Okumura, H., Ishigami, S., Hokita, S., & Natsugoe, S. (2013). Feasibility of sentinel node navigation surgery after noncurative endoscopic resection for early gastric cancer. Journal of Gastroenterology and Hepatology (Australia), 28(8), 1343-1347. https://doi.org/10.1111/jgh.12269