Fertility-sparing surgery of malignant transformation arising from mature cystic teratoma of the ovary

Nobuhisa Yoshikawa, Toshiya Teshigawara, Yoshiki Ikeda, Kimihiro Nishino, Jun Sakata, Fumi Utsumi, Kaoru Niimi, Ryuichiro Sekiya, Shiro Suzuki, Michiyasu Kawai, Kiyosumi Shibata, Fumitaka Kikkawa, Hiroaki Kajiyama

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Abstract

Background: The purpose of this study was to evaluate the long-term clinical outcome of young women with malignant transformation arising from mature cystic teratoma of the ovary (MT-MCT) by comparing radical surgery and fertility-sparing surgery (FSS). Patients and methods: All patients treated with radical surgery or FSS for MT-MCT in multiple institutions were registered in this analysis. Univariate and multivariate analyses were performed to evaluate clinical outcome, including overall survival (OS) and disease-free survival (DFS). Results: From 1986 to 2016, 62 patients with MT-MCT were treated in our group. The median follow-up period was 38.0 (2.0-227.9) months, and the median age was 54 (17-82) years old. Multivariate analysis revealed that only advanced stage was significantly correlated with poorer prognosis of patients [hazard ratio (HR) for death: 6.58, 95% confidence interval (CI): 1.82-24.78, P = 0.0048; HR for recurrence: 5.59, 95% CI: 1.52-21.83, P = 0.01]. Of a total of 13 women with stage I-II disease at less than 45 years old, 7 were treated with FSS, and there was no recurrence except for in one woman with stage II MT-MCT. There was no significant difference in long-term oncological outcome between radical surgery and FSS. Conclusion: FSS may be indicated for patients with stage I MT-MCT, who hope to preserve fertility, as no relapse was found after FSS.

Original languageEnglish
Pages (from-to)27564-27573
Number of pages10
JournalOncotarget
Volume9
Issue number44
DOIs
Publication statusPublished - 01-06-2018

All Science Journal Classification (ASJC) codes

  • Oncology

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    Yoshikawa, N., Teshigawara, T., Ikeda, Y., Nishino, K., Sakata, J., Utsumi, F., Niimi, K., Sekiya, R., Suzuki, S., Kawai, M., Shibata, K., Kikkawa, F., & Kajiyama, H. (2018). Fertility-sparing surgery of malignant transformation arising from mature cystic teratoma of the ovary. Oncotarget, 9(44), 27564-27573. https://doi.org/10.18632/oncotarget.25548