Five cases of locally advanced rectal cancer or local recurrence performed intra-arterial infusion chemotherapy via the internal iliac artery

Yoshikaze Koide, Koutaro Maeda, Tsunekazu Hanai, Harunobu Sato, Kouji Masumori, Hiroyuki Aoyama, Hidetoshi Katsuno, Masuo Funabashi, Toshiaki Kamano, Toshihisa Agata, Tomohito Noro

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Abstract

Intra-arterial infusion chemotherapy via the internal iliac artery was performed in 5 patients with locally advanced rectal cancer or recurrent rectal cancer. Arterial infusion chemotherapy was conducted into the internal iliac artery via bilateral femoral artery following a blood flow change with a coil. 5 FU 500 mg and l-leucovorin 125 mg/m2 were injected weekly. An average time of injections or its duration was 40 (17-74) times or 12.8 (5-23) months, respectively. Disappearance or improvement of symptoms was observed in 4 cases. A decrease of tumor size observed by CT was in 2 cases and a decrease of blood CEA level was in 3 cases. As for the complication of arterial infusion chemotherapy, dermatopathy was found in all of the cases, and sensory disturbance of lower extremities was in 3 cases, infection was in 2 cases and catheter obstruction was in 2 cases. A decrease of dosage or abundance of continuation was done during the course due to complications. Two patients with primary cancer died 1-3 years after the treatment, and 2 patients with recurrence died 7 months to 1 year after the treatment. One patient with primary cancer is continuing the treatment for the last 2 years though multiple metastatic diseases have been confirmed.

Original languageEnglish
Pages (from-to)1718-1720
Number of pages3
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume32
Issue number11
Publication statusPublished - 10-2005

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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