Five cases of thrombocytopenia induced by primary human herpesvirus 6 infection

Tetsushi Yoshikawa, Masashi Morooka, Sadao Suga, Yukihiko Niinomi, Tetsuichi Kaneko, Kunihiro Shinoda, Yoshiyuki Muraki, Koji Takahashi, Norio Sugaya, Yoshizo Asano

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Abstract Five patients suffering from exanthem subitum with thrombocytopenia were confirmed as primary human herpesvirus 6 (HHV-6) infection by serological test. All cases had thrombocytopenia during the acute phase of exanthem subitum. The clinical features of these cases were benign, and all recovered without any specific treatment. Moreover. 4 of the 5 cases showed a mild elevation of hepatic transaminase during the same period, and other viral infections including cytomegalovirus, Epstein-Barr virus, and human herpesvirus 7 were ruled out in these patients. It was speculated that direct inhibition of platelet production by the virus or cytokine induced by the virus-infected cells was the mechanism of the thrombocytopenia induced by primary HHV-6 infection.

Original languageEnglish
Pages (from-to)278-281
Number of pages4
JournalPediatrics International
Volume40
Issue number3
DOIs
Publication statusPublished - 01-01-1998

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Human Herpesvirus 6
Herpesviridae Infections
Thrombocytopenia
Exanthema
Human Herpesvirus 7
Viruses
Serologic Tests
Virus Diseases
Transaminases
Cytomegalovirus
Human Herpesvirus 4
Blood Platelets
Cytokines
Liver
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Yoshikawa, Tetsushi ; Morooka, Masashi ; Suga, Sadao ; Niinomi, Yukihiko ; Kaneko, Tetsuichi ; Shinoda, Kunihiro ; Muraki, Yoshiyuki ; Takahashi, Koji ; Sugaya, Norio ; Asano, Yoshizo. / Five cases of thrombocytopenia induced by primary human herpesvirus 6 infection. In: Pediatrics International. 1998 ; Vol. 40, No. 3. pp. 278-281.
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author = "Tetsushi Yoshikawa and Masashi Morooka and Sadao Suga and Yukihiko Niinomi and Tetsuichi Kaneko and Kunihiro Shinoda and Yoshiyuki Muraki and Koji Takahashi and Norio Sugaya and Yoshizo Asano",
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Yoshikawa, T, Morooka, M, Suga, S, Niinomi, Y, Kaneko, T, Shinoda, K, Muraki, Y, Takahashi, K, Sugaya, N & Asano, Y 1998, 'Five cases of thrombocytopenia induced by primary human herpesvirus 6 infection', Pediatrics International, vol. 40, no. 3, pp. 278-281. https://doi.org/10.1111/j.1442-200X.1998.tb01928.x

Five cases of thrombocytopenia induced by primary human herpesvirus 6 infection. / Yoshikawa, Tetsushi; Morooka, Masashi; Suga, Sadao; Niinomi, Yukihiko; Kaneko, Tetsuichi; Shinoda, Kunihiro; Muraki, Yoshiyuki; Takahashi, Koji; Sugaya, Norio; Asano, Yoshizo.

In: Pediatrics International, Vol. 40, No. 3, 01.01.1998, p. 278-281.

Research output: Contribution to journalArticle

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T1 - Five cases of thrombocytopenia induced by primary human herpesvirus 6 infection

AU - Yoshikawa, Tetsushi

AU - Morooka, Masashi

AU - Suga, Sadao

AU - Niinomi, Yukihiko

AU - Kaneko, Tetsuichi

AU - Shinoda, Kunihiro

AU - Muraki, Yoshiyuki

AU - Takahashi, Koji

AU - Sugaya, Norio

AU - Asano, Yoshizo

PY - 1998/1/1

Y1 - 1998/1/1

N2 - Abstract Five patients suffering from exanthem subitum with thrombocytopenia were confirmed as primary human herpesvirus 6 (HHV-6) infection by serological test. All cases had thrombocytopenia during the acute phase of exanthem subitum. The clinical features of these cases were benign, and all recovered without any specific treatment. Moreover. 4 of the 5 cases showed a mild elevation of hepatic transaminase during the same period, and other viral infections including cytomegalovirus, Epstein-Barr virus, and human herpesvirus 7 were ruled out in these patients. It was speculated that direct inhibition of platelet production by the virus or cytokine induced by the virus-infected cells was the mechanism of the thrombocytopenia induced by primary HHV-6 infection.

AB - Abstract Five patients suffering from exanthem subitum with thrombocytopenia were confirmed as primary human herpesvirus 6 (HHV-6) infection by serological test. All cases had thrombocytopenia during the acute phase of exanthem subitum. The clinical features of these cases were benign, and all recovered without any specific treatment. Moreover. 4 of the 5 cases showed a mild elevation of hepatic transaminase during the same period, and other viral infections including cytomegalovirus, Epstein-Barr virus, and human herpesvirus 7 were ruled out in these patients. It was speculated that direct inhibition of platelet production by the virus or cytokine induced by the virus-infected cells was the mechanism of the thrombocytopenia induced by primary HHV-6 infection.

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