Five cases of thrombocytopenia induced by primary human herpesvirus 6 infection

Tetsushi Yoshikawa, Masashi Morooka, Sadao Suga, Yukihiko Niinomi, Tetsuichi Kaneko, Kunihiro Shinoda, Yoshiyuki Muraki, Koji Takahashi, Norio Sugaya, Yoshizo Asano

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Abstract Five patients suffering from exanthem subitum with thrombocytopenia were confirmed as primary human herpesvirus 6 (HHV-6) infection by serological test. All cases had thrombocytopenia during the acute phase of exanthem subitum. The clinical features of these cases were benign, and all recovered without any specific treatment. Moreover. 4 of the 5 cases showed a mild elevation of hepatic transaminase during the same period, and other viral infections including cytomegalovirus, Epstein-Barr virus, and human herpesvirus 7 were ruled out in these patients. It was speculated that direct inhibition of platelet production by the virus or cytokine induced by the virus-infected cells was the mechanism of the thrombocytopenia induced by primary HHV-6 infection.

Original languageEnglish
Pages (from-to)278-281
Number of pages4
JournalPediatrics International
Issue number3
Publication statusPublished - 06-1998

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health


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