FKBP52 and FKBP51 differentially regulate the stability of estrogen receptor in breast cancer

Makoto Habara, Yuki Sato, Takahiro Goshima, Masashi Sakurai, Hiroyuki Imai, Hideyuki Shimizu, Yuta Katayama, Shunsuke Hanaki, Takahiro Masaki, Masahiro Morimoto, Sayaka Nishikawa, Tatsuya Toyama, Midori Shimada

Research output: Contribution to journalArticlepeer-review

Abstract

SignificanceEstrogen receptor α (ERα) is a transcription factor that induces cell proliferation and exhibits increased expression in a large subset of breast cancers. We comprehensively searched for indicators of poor prognosis in ERα-positive breast cancer through the multiple databases, including interactome, transcriptome, and survival analysis, and identified FKBP52. We found that two immunophilins, FKBP52 and FKBP51, have opposing effects on ERα stability and propose that therapeutic targeting of FKBP52 could be useful for the prevention and treatment of ERα-positive breast cancers, including endocrine therapy-resistant breast cancers.

Original languageEnglish
Pages (from-to)e2110256119
JournalProceedings of the National Academy of Sciences of the United States of America
Volume119
Issue number15
DOIs
Publication statusPublished - 12-04-2022
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General

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