TY - JOUR
T1 - Flavonoids protect mice from two types of lethal shock induced by endotoxin
AU - Takahashi, K.
AU - Morikawa, A.
AU - Kato, Y.
AU - Sugiyama, T.
AU - Koide, N.
AU - Mu, M. M.
AU - Yoshida, T.
AU - Yokochi, T.
N1 - Funding Information:
This work was supported by a grant from the Ministry of Education, Science, Sports and Culture and a grant for International Health Cooperation Research from the Ministry of Health and Welfare. We thank H. Sato (Toyo Seito) for providing αG·rutin.
PY - 2001
Y1 - 2001
N2 - The protective effect of flavonoids on two types of lethal endotoxic shock was studied. A lethal endotoxic shock was induced by administration of lipopolysaccharide (LPS) into D-galactosamine (D-GalN)-sensitized mice and another one was done by administration of a high dose of LPS into normal mice. Pretreatment with a series of flavonoids protected mice from two types of endotoxin lethality. Flavonoid pretreatment reduced the serum tumor necrosis factor-α (TNF-α) level in mice injected with D-GalN and LPS, but not in mice injected with a high dose of LPS. TNF-α-induced lethal shock in D-GalN-sensitized mice was also protected by pretreatment with flavonoids, suggesting that flavonoids augmented the resistance to TNF-α lethality. On the other hand, flavonoids reduced the plasma level of lipid peroxides in mice injected with a high dose of LPS, but not in D-GalN-sensitized mice. Taken together, these results indicated that flavonoids might protect mice from two types of endotoxin lethality. The protective mechanism of flavonoids in each endotoxin lethality is discussed.
AB - The protective effect of flavonoids on two types of lethal endotoxic shock was studied. A lethal endotoxic shock was induced by administration of lipopolysaccharide (LPS) into D-galactosamine (D-GalN)-sensitized mice and another one was done by administration of a high dose of LPS into normal mice. Pretreatment with a series of flavonoids protected mice from two types of endotoxin lethality. Flavonoid pretreatment reduced the serum tumor necrosis factor-α (TNF-α) level in mice injected with D-GalN and LPS, but not in mice injected with a high dose of LPS. TNF-α-induced lethal shock in D-GalN-sensitized mice was also protected by pretreatment with flavonoids, suggesting that flavonoids augmented the resistance to TNF-α lethality. On the other hand, flavonoids reduced the plasma level of lipid peroxides in mice injected with a high dose of LPS, but not in D-GalN-sensitized mice. Taken together, these results indicated that flavonoids might protect mice from two types of endotoxin lethality. The protective mechanism of flavonoids in each endotoxin lethality is discussed.
UR - http://www.scopus.com/inward/record.url?scp=0034884419&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034884419&partnerID=8YFLogxK
U2 - 10.1016/S0928-8244(01)00236-X
DO - 10.1016/S0928-8244(01)00236-X
M3 - Article
C2 - 11476978
AN - SCOPUS:0034884419
SN - 0928-8244
VL - 31
SP - 29
EP - 33
JO - FEMS Immunology and Medical Microbiology
JF - FEMS Immunology and Medical Microbiology
IS - 1
ER -
