Fluorescence in situ hybridization analysis of peripheral blood cells in Pearson marrow-pancreas syndrome

Itaru Yanagihara, Koji Inui, Keiko Yanagihara, Yong Dong Park, Junko Tanaka, Keiichi Ozono, Shintaro Okada, Hiroki Kurahashi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We used a dual-color fluorescence in situ hybridization technique to estimate deleted mitochondrial DNA at a single-cell level and determine any correlation with the disease progression in lymphocytes from patients with Pearson marrow-pancreas syndrome. The method demonstrated a shift in heteroplasmy, paralleling the hematologic improvement.

Original languageEnglish
Pages (from-to)452-455
Number of pages4
JournalJournal of Pediatrics
Volume139
Issue number3
DOIs
Publication statusPublished - 01-01-2001
Externally publishedYes

Fingerprint

Fluorescence In Situ Hybridization
Mitochondrial DNA
Disease Progression
Blood Cells
Color
Lymphocytes
VLCAD deficiency

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Yanagihara, Itaru ; Inui, Koji ; Yanagihara, Keiko ; Park, Yong Dong ; Tanaka, Junko ; Ozono, Keiichi ; Okada, Shintaro ; Kurahashi, Hiroki. / Fluorescence in situ hybridization analysis of peripheral blood cells in Pearson marrow-pancreas syndrome. In: Journal of Pediatrics. 2001 ; Vol. 139, No. 3. pp. 452-455.
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Yanagihara, I, Inui, K, Yanagihara, K, Park, YD, Tanaka, J, Ozono, K, Okada, S & Kurahashi, H 2001, 'Fluorescence in situ hybridization analysis of peripheral blood cells in Pearson marrow-pancreas syndrome', Journal of Pediatrics, vol. 139, no. 3, pp. 452-455. https://doi.org/10.1067/mpd.2001.116296

Fluorescence in situ hybridization analysis of peripheral blood cells in Pearson marrow-pancreas syndrome. / Yanagihara, Itaru; Inui, Koji; Yanagihara, Keiko; Park, Yong Dong; Tanaka, Junko; Ozono, Keiichi; Okada, Shintaro; Kurahashi, Hiroki.

In: Journal of Pediatrics, Vol. 139, No. 3, 01.01.2001, p. 452-455.

Research output: Contribution to journalArticle

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AU - Tanaka, Junko

AU - Ozono, Keiichi

AU - Okada, Shintaro

AU - Kurahashi, Hiroki

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