Fluorescence in situ hybridization analysis of peripheral blood cells in Pearson marrow-pancreas syndrome

Itaru Yanagihara; Koji Inui; Keiko Yanagihara; Yong Dong Park; Junko Tanaka; Keiichi Ozono; Shintaro Okada; Hiroki Kurahashi

doi:10.1067/mpd.2001.116296

Fluorescence in situ hybridization analysis of peripheral blood cells in Pearson marrow-pancreas syndrome

Itaru Yanagihara, Koji Inui, Keiko Yanagihara, Yong Dong Park, Junko Tanaka, Keiichi Ozono, Shintaro Okada, Hiroki Kurahashi

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

We used a dual-color fluorescence in situ hybridization technique to estimate deleted mitochondrial DNA at a single-cell level and determine any correlation with the disease progression in lymphocytes from patients with Pearson marrow-pancreas syndrome. The method demonstrated a shift in heteroplasmy, paralleling the hematologic improvement.

Original language	English
Pages (from-to)	452-455
Number of pages	4
Journal	Journal of Pediatrics
Volume	139
Issue number	3
DOIs	https://doi.org/10.1067/mpd.2001.116296
Publication status	Published - 2001
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pediatrics, Perinatology, and Child Health

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10.1067/mpd.2001.116296

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title = "Fluorescence in situ hybridization analysis of peripheral blood cells in Pearson marrow-pancreas syndrome",

abstract = "We used a dual-color fluorescence in situ hybridization technique to estimate deleted mitochondrial DNA at a single-cell level and determine any correlation with the disease progression in lymphocytes from patients with Pearson marrow-pancreas syndrome. The method demonstrated a shift in heteroplasmy, paralleling the hematologic improvement.",

author = "Itaru Yanagihara and Koji Inui and Keiko Yanagihara and Park, {Yong Dong} and Junko Tanaka and Keiichi Ozono and Shintaro Okada and Hiroki Kurahashi",

note = "Funding Information: Supported in part by grants from the Ministry of Education of Japan. ",

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T1 - Fluorescence in situ hybridization analysis of peripheral blood cells in Pearson marrow-pancreas syndrome

AU - Yanagihara, Itaru

AU - Inui, Koji

AU - Yanagihara, Keiko

AU - Park, Yong Dong

AU - Tanaka, Junko

AU - Ozono, Keiichi

AU - Okada, Shintaro

AU - Kurahashi, Hiroki

N1 - Funding Information: Supported in part by grants from the Ministry of Education of Japan.

PY - 2001

Y1 - 2001

N2 - We used a dual-color fluorescence in situ hybridization technique to estimate deleted mitochondrial DNA at a single-cell level and determine any correlation with the disease progression in lymphocytes from patients with Pearson marrow-pancreas syndrome. The method demonstrated a shift in heteroplasmy, paralleling the hematologic improvement.

AB - We used a dual-color fluorescence in situ hybridization technique to estimate deleted mitochondrial DNA at a single-cell level and determine any correlation with the disease progression in lymphocytes from patients with Pearson marrow-pancreas syndrome. The method demonstrated a shift in heteroplasmy, paralleling the hematologic improvement.

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Fluorescence in situ hybridization analysis of peripheral blood cells in Pearson marrow-pancreas syndrome

Abstract

All Science Journal Classification (ASJC) codes

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