Fluorescence in situ hybridization analysis of peripheral blood cells in Pearson marrow-pancreas syndrome

Itaru Yanagihara, Koji Inui, Keiko Yanagihara, Yong Dong Park, Junko Tanaka, Keiichi Ozono, Shintaro Okada, Hiroki Kurahashi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We used a dual-color fluorescence in situ hybridization technique to estimate deleted mitochondrial DNA at a single-cell level and determine any correlation with the disease progression in lymphocytes from patients with Pearson marrow-pancreas syndrome. The method demonstrated a shift in heteroplasmy, paralleling the hematologic improvement.

Original languageEnglish
Pages (from-to)452-455
Number of pages4
JournalJournal of Pediatrics
Volume139
Issue number3
DOIs
Publication statusPublished - 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

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