Fluvoxamine moderates reduced voluntary activity following chronic dexamethasone infusion in mice via recovery of BDNF signal cascades

Kazuki Terada, Nobuo Izumo, Biora Suzuki, Yoshiharu Karube, Tomomi Morikawa, Yukiko Ishibashi, Toshiki Kameyama, Koji Chiba, Noriko Sasaki, Keiko Iwata, Hideo Matsuzaki, Takayuki Manabe

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Major depression is a complex disorder characterized by genetic and environmental interactions. Selective serotonin reuptake inhibitors (SSRIs) effectively treat depression. Neurogenesis following chronic antidepressant treatment activates brain derived neurotrophic factor (BDNF) signaling. In this study, we analyzed the effects of the SSRI fluvoxamine (Flu) on locomotor activity and forced-swim behavior using chronic dexamethasone (cDEX) infusions in mice, which engenders depression-like behavior. Infusion of cDEX decreased body weight and produced a trend towards lower locomotor activity during darkness. In the forced-swim test, cDEX-mice exhibited increased immobility times compared with mice administered saline. Flu treatment reversed decreased locomotor activity and mitigated forced-swim test immobility. Real-time polymerase chain reactions using brain RNA samples yielded significantly lower BDNF mRNA levels in cDEX-mice compared with the saline group. Endoplasmic reticulum stress-associated X-box binding protein-1 (XBP1) gene expression was lower in cDEX-mice compared with the saline group. However, marked expression of the XBP1 gene was observed in cDEX-mice treated with Flu compared with mice given saline and untreated cDEX-mice. Expression of 5-HT2A and Sigma-1 receptors decreased after cDEX infusion compared with the saline group, and these decreases normalized to control levels upon Flu treatment. Our results indicate that the Flu moderates reductions in voluntary activity following chronic dexamethasone infusions in mice via recovery of BDNF signal cascades.

Original languageEnglish
Pages (from-to)9-13
Number of pages5
JournalNeurochemistry International
Volume69
Issue number1
DOIs
Publication statusPublished - 01-01-2014

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Fluvoxamine
Brain-Derived Neurotrophic Factor
Dexamethasone
Locomotion
Serotonin Uptake Inhibitors
Depression
Inborn Genetic Diseases
Endoplasmic Reticulum Stress
Darkness
Neurogenesis
Antidepressive Agents
Real-Time Polymerase Chain Reaction
Body Weight
RNA
Gene Expression
Messenger RNA

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience
  • Cell Biology

Cite this

Terada, Kazuki ; Izumo, Nobuo ; Suzuki, Biora ; Karube, Yoshiharu ; Morikawa, Tomomi ; Ishibashi, Yukiko ; Kameyama, Toshiki ; Chiba, Koji ; Sasaki, Noriko ; Iwata, Keiko ; Matsuzaki, Hideo ; Manabe, Takayuki. / Fluvoxamine moderates reduced voluntary activity following chronic dexamethasone infusion in mice via recovery of BDNF signal cascades. In: Neurochemistry International. 2014 ; Vol. 69, No. 1. pp. 9-13.
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Terada, K, Izumo, N, Suzuki, B, Karube, Y, Morikawa, T, Ishibashi, Y, Kameyama, T, Chiba, K, Sasaki, N, Iwata, K, Matsuzaki, H & Manabe, T 2014, 'Fluvoxamine moderates reduced voluntary activity following chronic dexamethasone infusion in mice via recovery of BDNF signal cascades', Neurochemistry International, vol. 69, no. 1, pp. 9-13. https://doi.org/10.1016/j.neuint.2014.02.002

Fluvoxamine moderates reduced voluntary activity following chronic dexamethasone infusion in mice via recovery of BDNF signal cascades. / Terada, Kazuki; Izumo, Nobuo; Suzuki, Biora; Karube, Yoshiharu; Morikawa, Tomomi; Ishibashi, Yukiko; Kameyama, Toshiki; Chiba, Koji; Sasaki, Noriko; Iwata, Keiko; Matsuzaki, Hideo; Manabe, Takayuki.

In: Neurochemistry International, Vol. 69, No. 1, 01.01.2014, p. 9-13.

Research output: Contribution to journalArticle

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AU - Terada, Kazuki

AU - Izumo, Nobuo

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AU - Morikawa, Tomomi

AU - Ishibashi, Yukiko

AU - Kameyama, Toshiki

AU - Chiba, Koji

AU - Sasaki, Noriko

AU - Iwata, Keiko

AU - Matsuzaki, Hideo

AU - Manabe, Takayuki

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