Fluvoxamine reverses estrogen-dependent decline in voluntary activities and decreased amygdala levels of serotonin in ovariectomized rats

Yukiko Lshibashi, Nobuo Lzumo, Keiko Lwata, Tomomi Morikawa, Toshiki Kameyama, Yasuo Watanabe, Takayuki Manabe, Hideo Matsuzaki

Research output: Contribution to journalArticle

Abstract

Studies suggest that increased expression of brain-derived neurotrophic factor (BDNF) could mediate the antidepressant effects of drugs. We analyzed the effects of fluvoxamine on locomotor activities, serotonin levels in the amygdala, and hippocampal expression of BDNF mRNA in ovariectomized (OVX) rats. Female Wistar rats (8 weeks, 180-200 g) were divided into four groups: sham; OVX; OVX with estrogen; and OVX with fluvoxamine. Six weeks after ovariectomy, rats were assessed according to spontaneous locomotor activity, forced-swimming test (FST), and microdialyses experiments. Body and uterine weight of OVX rats 6 weeks after surgery were significantly increased and decreased, respectively, compared with those of the sham group, but these changes were returned to sham-group levels upon chronic administration of estrogen and fluvoxamine. More potent decreases in voluntary activities were observed in OVX rats compared with rats in the sham group, but were increased markedly upon administration of estrogen and fluvoxamine. In the FST, immobility time and beat counts were increased and decreased significantly by ovariectomy compared with those of the sham group, respectively, but estrogen and fluvoxamine treatment reversed these changes significantly. More potent decreases in serotonin release in the amygdala were observed in OVX rats compared with those of sham rats, but were reversed upon estrogen replacement. Similar recovery was observed in OVX rats upon fluvoxamine treatment. These data suggest that, in OVX rats, chronic administration of fluvoxamine can recover estrogen-dependent changes in behaviors, decreased serotonin release in the amygdala, and reduced expression of BDNF mRNA.

Original languageEnglish
Pages (from-to)5-19
Number of pages15
JournalJournal of Brain Science
Volume46
Publication statusPublished - 30-06-2016

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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