TY - JOUR
T1 - Focal macular electroretinogram in X-linked congenital retinoschisis
AU - Miyake, Y.
AU - Shiroyama, N.
AU - Ota, I.
AU - Horiguchi, M.
PY - 1993
Y1 - 1993
N2 - Purpose. To study macular function of X-linked congenital retinoschisis (CRS) by focal macular electroretinogram (MERG). Methods. MERGs were recorded with 5°, 10°, and 15° spots in 20 patients with CRS. Seventeen patients showed foveal schisis with little or no change in foveal fluorescein angiography (Group 1), and three patients showed advanced macular changes with nonspecific macular degeneration (Group 2). Results. In Group 1, a-wave amplitudes were within the normal range, but b-waves and oscillatory potentials (OPs) had mean amplitudes significantly below those for normal control subjects. The mean b- to a-wave ratios, significantly lower than in normal eyes, decreased significantly with decreasing spot size. The implicit times of a-waves, b-waves, and OPs were significantly delayed. In Group 2, MERGs were nearly nondetectable. Conclusions. The macular pathology of CSR exists mainly in the middle and inner retinal layers, disturbing the fovea more than the perifovea, whereas degeneration of photoreceptors progresses in more advanced stage.
AB - Purpose. To study macular function of X-linked congenital retinoschisis (CRS) by focal macular electroretinogram (MERG). Methods. MERGs were recorded with 5°, 10°, and 15° spots in 20 patients with CRS. Seventeen patients showed foveal schisis with little or no change in foveal fluorescein angiography (Group 1), and three patients showed advanced macular changes with nonspecific macular degeneration (Group 2). Results. In Group 1, a-wave amplitudes were within the normal range, but b-waves and oscillatory potentials (OPs) had mean amplitudes significantly below those for normal control subjects. The mean b- to a-wave ratios, significantly lower than in normal eyes, decreased significantly with decreasing spot size. The implicit times of a-waves, b-waves, and OPs were significantly delayed. In Group 2, MERGs were nearly nondetectable. Conclusions. The macular pathology of CSR exists mainly in the middle and inner retinal layers, disturbing the fovea more than the perifovea, whereas degeneration of photoreceptors progresses in more advanced stage.
KW - X-linked congenital retinoschisis
KW - b-wave to a-wave ratio
KW - focal macular ERG
KW - oscillatory potentials
KW - photoreceptor function
UR - http://www.scopus.com/inward/record.url?scp=0027477926&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027477926&partnerID=8YFLogxK
M3 - Article
C2 - 8449671
AN - SCOPUS:0027477926
SN - 0146-0404
VL - 34
SP - 512
EP - 515
JO - Investigative Ophthalmology and Visual Science
JF - Investigative Ophthalmology and Visual Science
IS - 3
ER -