Focal macular electroretinogram in X-linked congenital retinoschisis

Y. Miyake, N. Shiroyama, I. Ota, M. Horiguchi

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41 Citations (Scopus)


Purpose. To study macular function of X-linked congenital retinoschisis (CRS) by focal macular electroretinogram (MERG). Methods. MERGs were recorded with 5°, 10°, and 15° spots in 20 patients with CRS. Seventeen patients showed foveal schisis with little or no change in foveal fluorescein angiography (Group 1), and three patients showed advanced macular changes with nonspecific macular degeneration (Group 2). Results. In Group 1, a-wave amplitudes were within the normal range, but b-waves and oscillatory potentials (OPs) had mean amplitudes significantly below those for normal control subjects. The mean b- to a-wave ratios, significantly lower than in normal eyes, decreased significantly with decreasing spot size. The implicit times of a-waves, b-waves, and OPs were significantly delayed. In Group 2, MERGs were nearly nondetectable. Conclusions. The macular pathology of CSR exists mainly in the middle and inner retinal layers, disturbing the fovea more than the perifovea, whereas degeneration of photoreceptors progresses in more advanced stage.

Original languageEnglish
Pages (from-to)512-515
Number of pages4
JournalInvestigative Ophthalmology and Visual Science
Issue number3
Publication statusPublished - 1993
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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