TY - JOUR
T1 - Follicular helper T cells in the pathogenesis of IgG4-related disease
AU - Akiyama, Mitsuhiro
AU - Suzuki, Katsuya
AU - Yasuoka, Hidekata
AU - Kaneko, Yuko
AU - Yamaoka, Kunihiro
AU - Takeuchi, Tsutomu
N1 - Funding Information:
Disclosure statement: Y.T. has received consultant fees from Pfizer, Chugai Pharma, Mitsubishi-Tanabe Pharma and AbbVie, received honoraria from Pfizer, Chugai Pharma, Mitsubishi-Tanabe Pharma, Bristol-Myers Squibb, Takeda Industrial Pharma, GlaxoSmithkline, Nippon Shinyaku, Eli Lilly, Janssen Pharma, Eisai Pharma, Astellas Pharma and Actelion Pharmaceuticals and received research support from Chugai Pharma and Mitsubishi-Tanabe Pharma. T.T has received consulting fees, speaking fees and/or honoraria from Pfizer Japan,
Publisher Copyright:
© The Author 2017. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2018/2/1
Y1 - 2018/2/1
N2 - IgG4-related disease (IgG4-RD) is a recently recognized disease entity characterized by high serum IgG4 concentrations and infiltration of IgG4+ plasma cells with hyperplastic ectopic germinal centres at affected sites. Although the underlying immune mechanism of this disease remains unclear, T cells are abundantly present at affected sites and key players in IgG4-RD pathogenesis. The role of T cell subsets has been investigated thoroughly in this disease. Recent advances in this field have clarified the importance of T follicular helper cells. In this review, we describe the role of T follicular helper cells in the disease process of IgG4-RD, in particular, for IgG4 class-switching, plasmablast and plasma cell differentiation, and germinal centre formation.
AB - IgG4-related disease (IgG4-RD) is a recently recognized disease entity characterized by high serum IgG4 concentrations and infiltration of IgG4+ plasma cells with hyperplastic ectopic germinal centres at affected sites. Although the underlying immune mechanism of this disease remains unclear, T cells are abundantly present at affected sites and key players in IgG4-RD pathogenesis. The role of T cell subsets has been investigated thoroughly in this disease. Recent advances in this field have clarified the importance of T follicular helper cells. In this review, we describe the role of T follicular helper cells in the disease process of IgG4-RD, in particular, for IgG4 class-switching, plasmablast and plasma cell differentiation, and germinal centre formation.
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U2 - 10.1093/rheumatology/kex171
DO - 10.1093/rheumatology/kex171
M3 - Review article
C2 - 28460058
AN - SCOPUS:85041503887
VL - 57
SP - 236
EP - 245
JO - Rheumatology and Rehabilitation
JF - Rheumatology and Rehabilitation
SN - 1462-0324
IS - 2
M1 - kex171
ER -