Follicular lymphoma suggested to transform into EBV-negative plasmablastic lymphoma

Toshiki Yamada, Takeshi Hara, Naoe Goto, Hitoshi Iwata, Hisashi Tsurumi

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Follicular lymphoma (FL) is an indolent lymphoma that often transforms into a high-grade lymphoma, mostly diffuse large B-cell lymphoma. A case of FL suggested to transform into plasmablastic lymphoma is presented. A 59-year-old man was admitted to our hospital because of right lower abdominal pain and vomiting. Computed tomography showed a mass in the ileocecum. Colonoscopy showed a mass with an ulcer in the ascending colon, and surgery was performed. Immunohistochemical staining of the biopsied mass showed infiltrated lymphocytes that were positive for CD38, CD45, CD138, and λ chain, and negative for CD4, CD5, CD8, CD10, CD20, CD56, and κ chain. Flow cytometric analysis of the ascites showed similar results. FISH analyses performed using lymph node biopsy specimens, ascite fluid and pleural effusion fluid identified the presence of an IGH/BCL2 translocation. FL was suggested to transform into PBL. Although the patient received three courses of R-CHOP chemotherapy and salvage chemotherapy, the patient died because of lymphoma progression less than 6 months after the diagnosis of PBL. Transformation of FL to PBL is highly unusual. The lack of a standard treatment for PBL results in the poor outcome of this entity. Novel therapeutic approaches are needed.

Original languageEnglish
Pages (from-to)723-730
Number of pages8
JournalInternational Journal of Hematology
Issue number6
Publication statusPublished - 06-2019
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Hematology


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