TY - JOUR
T1 - Follicular variant of peripheral T-cell lymphoma mimicking follicular lymphoma
T2 - A case report with a review of the Literature
AU - Goto, Naoe
AU - Tsurumi, Hisashi
AU - Sawada, Michio
AU - Kanemura, Nobuhiro
AU - Hara, Takeshi
AU - Kasahara, Senji
AU - Kito, Yusuke
AU - Takada, Katsuyoshi
AU - Sato, Yasuharu
AU - Yoshino, Tadashi
AU - Moriwaki, Hisataka
AU - Takami, Tsuyoshi
PY - 2011/5
Y1 - 2011/5
N2 - Peripheral T-cell lymphoma (PTCL) with a follicular growth pattern is very rare. Herein, a case of follicular variant of PTCL in a 50-year-old man who complained of tonsillar and generalized lymph node swelling is reported. The resected tonsil revealed a vague nodular growth pattern of atypical cells, medium to large in size, with abundant pale cytoplasm. The lymphoma cells were CD3 + CD4 + CD5 + CD8 - CD10 + CD56 - CD57 - BCL6 + PD-1 + CXCL13 + and were associated with a meshwork of CD21 + follicular dendritic cells. Molecular studies revealed clonal rearrangement of the T-cell receptor gamma chain gene but not of the immunoglobulin gene. Cytogenetic analysis disclosed a complex abnormality in 18 of 20 cells with the exclusion of t(5; 9). These findings suggest that the present case is a follicular variant of PTCL derived from follicular T-helper cells.
AB - Peripheral T-cell lymphoma (PTCL) with a follicular growth pattern is very rare. Herein, a case of follicular variant of PTCL in a 50-year-old man who complained of tonsillar and generalized lymph node swelling is reported. The resected tonsil revealed a vague nodular growth pattern of atypical cells, medium to large in size, with abundant pale cytoplasm. The lymphoma cells were CD3 + CD4 + CD5 + CD8 - CD10 + CD56 - CD57 - BCL6 + PD-1 + CXCL13 + and were associated with a meshwork of CD21 + follicular dendritic cells. Molecular studies revealed clonal rearrangement of the T-cell receptor gamma chain gene but not of the immunoglobulin gene. Cytogenetic analysis disclosed a complex abnormality in 18 of 20 cells with the exclusion of t(5; 9). These findings suggest that the present case is a follicular variant of PTCL derived from follicular T-helper cells.
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U2 - 10.1111/j.1440-1827.2011.02656.x
DO - 10.1111/j.1440-1827.2011.02656.x
M3 - Article
C2 - 21501301
AN - SCOPUS:79955005375
SN - 1320-5463
VL - 61
SP - 326
EP - 330
JO - Pathology International
JF - Pathology International
IS - 5
ER -