TY - JOUR
T1 - Food-Dependent Exercise-Induced Anaphylaxis Caused by Carrots
T2 - A Case Report
AU - Hirai, Nami
AU - Ogata, Mika
AU - Kido, Jun
AU - Nakamura, Masashi
AU - Sato, Nayu
AU - Takamatsu, Nobue
AU - Shimojo, Naoshi
AU - Aoki, Yuji
AU - Matsunaga, Kayoko
AU - Mizukami, Tomoyuki
N1 - Publisher Copyright:
© 2022 Mary Ann Liebert, Inc., publishers.
PY - 2022/12
Y1 - 2022/12
N2 - Background: Most cases of food-dependent exercise-induced anaphylaxis (FDEIA) are caused by eating wheat or crustaceans. However, fruits or vegetables may rarely act as allergens for FDEIA. We report a rare case of FDEIA caused by eating carrots. Case Presentation: An 8-year-old boy developed an anaphylactic reaction while playing, after eating lunch that included cooked carrots. Serum carrot-specific immunoglobulin E level was 0.19 UA/mL. The prick-by-prick test for raw carrots was positive (wheal diameter: 4 mm). The patient developed urticaria after exercise provocation tests following ingestion of raw carrots. Carrot proteins were analyzed by 2-dimensional Western blotting to identify the causative allergens. Nine proteins were identified as candidate antigens at 21-66 kDa. Conclusions: Our patient presented with FDEIA symptoms after ingesting both raw and cooked carrots. Both raw and cooked carrots contain 9 proteins that may induce FDEIA.
AB - Background: Most cases of food-dependent exercise-induced anaphylaxis (FDEIA) are caused by eating wheat or crustaceans. However, fruits or vegetables may rarely act as allergens for FDEIA. We report a rare case of FDEIA caused by eating carrots. Case Presentation: An 8-year-old boy developed an anaphylactic reaction while playing, after eating lunch that included cooked carrots. Serum carrot-specific immunoglobulin E level was 0.19 UA/mL. The prick-by-prick test for raw carrots was positive (wheal diameter: 4 mm). The patient developed urticaria after exercise provocation tests following ingestion of raw carrots. Carrot proteins were analyzed by 2-dimensional Western blotting to identify the causative allergens. Nine proteins were identified as candidate antigens at 21-66 kDa. Conclusions: Our patient presented with FDEIA symptoms after ingesting both raw and cooked carrots. Both raw and cooked carrots contain 9 proteins that may induce FDEIA.
UR - https://www.scopus.com/pages/publications/85144588850
UR - https://www.scopus.com/pages/publications/85144588850#tab=citedBy
U2 - 10.1089/ped.2022.0122
DO - 10.1089/ped.2022.0122
M3 - Article
C2 - 36445747
AN - SCOPUS:85144588850
SN - 2151-321X
VL - 35
SP - 166
EP - 169
JO - Pediatric, Allergy, Immunology, and Pulmonology
JF - Pediatric, Allergy, Immunology, and Pulmonology
IS - 4
ER -