Formation of psammoma bodies in meningocytic whorls - Ultrastructural study and analysis of calcified material

T. Kubota, T. Yamashima, M. Hasegawa, S. Kida, M. Hayashi, S. Yamamoto

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Psammoma bodies in meningocytic whorls were investigated by electron microscopy. In some whorls, connective tissue fibers were seen and membrane-bound vesicles were contiguous to degenerated cells. Some small vesicles, 0.1 to 0.5 μm in diameter, were outlined by plasma membrane (matrix vesicles), other larger ones, about 1 to several μm in diameter, were invested by a thick wall (matrix giant bodies). Mineralized deposits were frequent in these vesicles and occasionally large masses of mineralized connective tissue fibers (psammoma bodies) were seen. Analysis of the material in the mineralized vesicles and fibers, using an energy dispersive X-ray microanalyzer, showed that both calcium and phosphorous were evident and hydroxyapatite was substantiated using an X-ray differactometer. Psammoma body formation in the meningocytic whorls may represent degeneration in some whorls of the central cells which contain connective tissue fibers, producing cell debris such as membrane invested vesicles. Subsequently, calcification occurs in these vesicles, and the mineralization process extends to neighboring connective tissue fibers. The calcified mass forms a psammoma body.

Original languageEnglish
Pages (from-to)262-268
Number of pages7
JournalActa Neuropathologica
Volume70
Issue number3-4
DOIs
Publication statusPublished - 09-1986
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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