Four cases of human herpesvirus 6 variant B infection after pediatric liver transplantation

Tetsushi Yoshikawa, Masaru Ihira, Hiroshi Furukawa, Sadao Suga, Katsuhiro Asonuma, Koichi Tanaka, Yoshizo Asano

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background. Little is known about human herpesvirus (HHV)-6 infection after liver transplantation. We present our experiences with four cases of HHV-6 infection after liver transplantation from living related donors. Methods. Peripheral blood was collected from four donor and recipient pairs at the time of transplantation and biweekly from the recipients after transplantation. We attempted to isolate HHV-6 and measure antibody titers to HHV-6 and HHV-7. Results. HHV-6 was isolated from four recipients approximately 2 weeks after transplantation. A significant rise in HHV-6 antibody titers was observed in four recipients at some point in their course, whereas HHV-7 antibody titers were increased in one recipient. Four isolates were variant B. When HHV-6 was isolated, all recipients had an unexplained fever. Conclusions. HHV-6 variant B infection after pediatric liver transplantation was confirmed. HHV-6 infection occurred approximately 2 weeks after transplantation. Moreover, there appears to be an association between HHV-6 infection and unexplained fever.

Original languageEnglish
Pages (from-to)1266-1269
Number of pages4
JournalTransplantation
Volume65
Issue number9
DOIs
Publication statusPublished - 15-05-1998

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Human Herpesvirus 6
Liver Transplantation
Pediatrics
Herpesviridae Infections
Infection
Human Herpesvirus 7
Transplantation
Antibodies
Fever
Living Donors
Tissue Donors

All Science Journal Classification (ASJC) codes

  • Transplantation

Cite this

Yoshikawa, Tetsushi ; Ihira, Masaru ; Furukawa, Hiroshi ; Suga, Sadao ; Asonuma, Katsuhiro ; Tanaka, Koichi ; Asano, Yoshizo. / Four cases of human herpesvirus 6 variant B infection after pediatric liver transplantation. In: Transplantation. 1998 ; Vol. 65, No. 9. pp. 1266-1269.
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abstract = "Background. Little is known about human herpesvirus (HHV)-6 infection after liver transplantation. We present our experiences with four cases of HHV-6 infection after liver transplantation from living related donors. Methods. Peripheral blood was collected from four donor and recipient pairs at the time of transplantation and biweekly from the recipients after transplantation. We attempted to isolate HHV-6 and measure antibody titers to HHV-6 and HHV-7. Results. HHV-6 was isolated from four recipients approximately 2 weeks after transplantation. A significant rise in HHV-6 antibody titers was observed in four recipients at some point in their course, whereas HHV-7 antibody titers were increased in one recipient. Four isolates were variant B. When HHV-6 was isolated, all recipients had an unexplained fever. Conclusions. HHV-6 variant B infection after pediatric liver transplantation was confirmed. HHV-6 infection occurred approximately 2 weeks after transplantation. Moreover, there appears to be an association between HHV-6 infection and unexplained fever.",
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Four cases of human herpesvirus 6 variant B infection after pediatric liver transplantation. / Yoshikawa, Tetsushi; Ihira, Masaru; Furukawa, Hiroshi; Suga, Sadao; Asonuma, Katsuhiro; Tanaka, Koichi; Asano, Yoshizo.

In: Transplantation, Vol. 65, No. 9, 15.05.1998, p. 1266-1269.

Research output: Contribution to journalArticle

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T1 - Four cases of human herpesvirus 6 variant B infection after pediatric liver transplantation

AU - Yoshikawa, Tetsushi

AU - Ihira, Masaru

AU - Furukawa, Hiroshi

AU - Suga, Sadao

AU - Asonuma, Katsuhiro

AU - Tanaka, Koichi

AU - Asano, Yoshizo

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AB - Background. Little is known about human herpesvirus (HHV)-6 infection after liver transplantation. We present our experiences with four cases of HHV-6 infection after liver transplantation from living related donors. Methods. Peripheral blood was collected from four donor and recipient pairs at the time of transplantation and biweekly from the recipients after transplantation. We attempted to isolate HHV-6 and measure antibody titers to HHV-6 and HHV-7. Results. HHV-6 was isolated from four recipients approximately 2 weeks after transplantation. A significant rise in HHV-6 antibody titers was observed in four recipients at some point in their course, whereas HHV-7 antibody titers were increased in one recipient. Four isolates were variant B. When HHV-6 was isolated, all recipients had an unexplained fever. Conclusions. HHV-6 variant B infection after pediatric liver transplantation was confirmed. HHV-6 infection occurred approximately 2 weeks after transplantation. Moreover, there appears to be an association between HHV-6 infection and unexplained fever.

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