Four cases of sporadic acute hepatitis E in Mie, Japan who were infected with European type genotype 3 hepatitis E virus

Hiroshi Okano, Tatsunori Nakano, Shimpei Matsusaki, Tomohiro Sase, Tomonori Saitou, Katsumi Mukai, Akira Nishimura, Keiichi Ito, Katsuya Shiraki, Yoshiyuki Takei, Hiroaki Okamoto

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Abstract

From 2004 to 2010, we have seen four cases of sporadic acute hepatitis E in nothern or central district of Mie Prefecture, Japan, who contracted infection of rare genotype 3 hepatitis E virus (HEV) strains. The HEV strains recovered from the four patients were 99.3-99.5% identical to each other in the 412-nucleotide sequence within ORF2 and homologous to those circulating in European countries such as Spain, United Kingdom, and the Netherlands, suggesting the long-term maintenance of the European type genotype 3 HEV strains in a restricted area in Japan. None of these four patients had histories of consuming uncooked or undercooked meat and/or viscera from infected animals and of travel to European countries, and the source of infectious origin remains unknown. These results warrant careful observation of clinical and subclinical HEV infection in this area and implementation of infection prevention measures in the future.

Original languageEnglish
Pages (from-to)295-302
Number of pages8
JournalActa Hepatologica Japonica
Volume52
Issue number5
DOIs
Publication statusPublished - 24-06-2011

All Science Journal Classification (ASJC) codes

  • Hepatology

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    Okano, H., Nakano, T., Matsusaki, S., Sase, T., Saitou, T., Mukai, K., Nishimura, A., Ito, K., Shiraki, K., Takei, Y., & Okamoto, H. (2011). Four cases of sporadic acute hepatitis E in Mie, Japan who were infected with European type genotype 3 hepatitis E virus. Acta Hepatologica Japonica, 52(5), 295-302. https://doi.org/10.2957/kanzo.52.295