Frequency of epidermal growth factor receptor mutations in Bangladeshi patients with adenocarcinoma of the lung

Shakibur Rahman, Nobuyuki Kondo, Kazue Yoneda, Teruhisa Takuwa, Masaki Hashimoto, Hayato Orui, Yoshitomo Okumura, Fumihiro Tanaka, Kanako Kumamoto, Mohammad Golam Mostafa, Golam Mohiuddin Akbar Chowdhury, Akramul Haque, Seiki Hasegawa

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Worldwide studies on lung adenocarcinoma have demonstrated a genetic divergence of the epidermal growth factor receptor (EGFR) pathway according to ethnicity, such as higher frequency of activated EGFR mutations among East Asian patients. However, such information is still lacking in some developing countries. Methods: We investigated the frequency of EGFR mutations among Bangladeshi patients with adenocarcinoma of the lung. Fine-needle aspiration tissue samples were collected from 61 Bangladeshi patients. Polymerase chain reaction-single-strand conformation polymorphism was performed on extracted DNA for mutational analysis of EGFR exons 19 and 21. Results: EGFR mutations were found in 14 of 61 (23.0 %) Bangladeshi patients. There was no significant difference in EGFR mutation rate with regard to patient's age, sex, smoking history, clinical stage of lung cancer, subtypes of adenocarcinoma, and tumor differentiation. Conclusion: The present study revealed that the EGFR mutation rate in Bangladeshi patients with adenocarcinoma of the lung was higher than in African-American, Arabian, and white Caucasian patients, and was lower than in East Asia.

Original languageEnglish
Pages (from-to)45-49
Number of pages5
JournalInternational Journal of Clinical Oncology
Volume19
Issue number1
DOIs
Publication statusPublished - 01-02-2014

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Epidermal Growth Factor Receptor
Mutation
Mutation Rate
DNA Mutational Analysis
Far East
Fine Needle Biopsy
Adenocarcinoma of lung
African Americans
Developing Countries
Exons
Lung Neoplasms
Adenocarcinoma
Smoking
History
Polymerase Chain Reaction
Neoplasms

All Science Journal Classification (ASJC) codes

  • Surgery
  • Hematology
  • Oncology

Cite this

Rahman, Shakibur ; Kondo, Nobuyuki ; Yoneda, Kazue ; Takuwa, Teruhisa ; Hashimoto, Masaki ; Orui, Hayato ; Okumura, Yoshitomo ; Tanaka, Fumihiro ; Kumamoto, Kanako ; Mostafa, Mohammad Golam ; Chowdhury, Golam Mohiuddin Akbar ; Haque, Akramul ; Hasegawa, Seiki. / Frequency of epidermal growth factor receptor mutations in Bangladeshi patients with adenocarcinoma of the lung. In: International Journal of Clinical Oncology. 2014 ; Vol. 19, No. 1. pp. 45-49.
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abstract = "Background: Worldwide studies on lung adenocarcinoma have demonstrated a genetic divergence of the epidermal growth factor receptor (EGFR) pathway according to ethnicity, such as higher frequency of activated EGFR mutations among East Asian patients. However, such information is still lacking in some developing countries. Methods: We investigated the frequency of EGFR mutations among Bangladeshi patients with adenocarcinoma of the lung. Fine-needle aspiration tissue samples were collected from 61 Bangladeshi patients. Polymerase chain reaction-single-strand conformation polymorphism was performed on extracted DNA for mutational analysis of EGFR exons 19 and 21. Results: EGFR mutations were found in 14 of 61 (23.0 {\%}) Bangladeshi patients. There was no significant difference in EGFR mutation rate with regard to patient's age, sex, smoking history, clinical stage of lung cancer, subtypes of adenocarcinoma, and tumor differentiation. Conclusion: The present study revealed that the EGFR mutation rate in Bangladeshi patients with adenocarcinoma of the lung was higher than in African-American, Arabian, and white Caucasian patients, and was lower than in East Asia.",
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Rahman, S, Kondo, N, Yoneda, K, Takuwa, T, Hashimoto, M, Orui, H, Okumura, Y, Tanaka, F, Kumamoto, K, Mostafa, MG, Chowdhury, GMA, Haque, A & Hasegawa, S 2014, 'Frequency of epidermal growth factor receptor mutations in Bangladeshi patients with adenocarcinoma of the lung', International Journal of Clinical Oncology, vol. 19, no. 1, pp. 45-49. https://doi.org/10.1007/s10147-012-0515-4

Frequency of epidermal growth factor receptor mutations in Bangladeshi patients with adenocarcinoma of the lung. / Rahman, Shakibur; Kondo, Nobuyuki; Yoneda, Kazue; Takuwa, Teruhisa; Hashimoto, Masaki; Orui, Hayato; Okumura, Yoshitomo; Tanaka, Fumihiro; Kumamoto, Kanako; Mostafa, Mohammad Golam; Chowdhury, Golam Mohiuddin Akbar; Haque, Akramul; Hasegawa, Seiki.

In: International Journal of Clinical Oncology, Vol. 19, No. 1, 01.02.2014, p. 45-49.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Frequency of epidermal growth factor receptor mutations in Bangladeshi patients with adenocarcinoma of the lung

AU - Rahman, Shakibur

AU - Kondo, Nobuyuki

AU - Yoneda, Kazue

AU - Takuwa, Teruhisa

AU - Hashimoto, Masaki

AU - Orui, Hayato

AU - Okumura, Yoshitomo

AU - Tanaka, Fumihiro

AU - Kumamoto, Kanako

AU - Mostafa, Mohammad Golam

AU - Chowdhury, Golam Mohiuddin Akbar

AU - Haque, Akramul

AU - Hasegawa, Seiki

PY - 2014/2/1

Y1 - 2014/2/1

N2 - Background: Worldwide studies on lung adenocarcinoma have demonstrated a genetic divergence of the epidermal growth factor receptor (EGFR) pathway according to ethnicity, such as higher frequency of activated EGFR mutations among East Asian patients. However, such information is still lacking in some developing countries. Methods: We investigated the frequency of EGFR mutations among Bangladeshi patients with adenocarcinoma of the lung. Fine-needle aspiration tissue samples were collected from 61 Bangladeshi patients. Polymerase chain reaction-single-strand conformation polymorphism was performed on extracted DNA for mutational analysis of EGFR exons 19 and 21. Results: EGFR mutations were found in 14 of 61 (23.0 %) Bangladeshi patients. There was no significant difference in EGFR mutation rate with regard to patient's age, sex, smoking history, clinical stage of lung cancer, subtypes of adenocarcinoma, and tumor differentiation. Conclusion: The present study revealed that the EGFR mutation rate in Bangladeshi patients with adenocarcinoma of the lung was higher than in African-American, Arabian, and white Caucasian patients, and was lower than in East Asia.

AB - Background: Worldwide studies on lung adenocarcinoma have demonstrated a genetic divergence of the epidermal growth factor receptor (EGFR) pathway according to ethnicity, such as higher frequency of activated EGFR mutations among East Asian patients. However, such information is still lacking in some developing countries. Methods: We investigated the frequency of EGFR mutations among Bangladeshi patients with adenocarcinoma of the lung. Fine-needle aspiration tissue samples were collected from 61 Bangladeshi patients. Polymerase chain reaction-single-strand conformation polymorphism was performed on extracted DNA for mutational analysis of EGFR exons 19 and 21. Results: EGFR mutations were found in 14 of 61 (23.0 %) Bangladeshi patients. There was no significant difference in EGFR mutation rate with regard to patient's age, sex, smoking history, clinical stage of lung cancer, subtypes of adenocarcinoma, and tumor differentiation. Conclusion: The present study revealed that the EGFR mutation rate in Bangladeshi patients with adenocarcinoma of the lung was higher than in African-American, Arabian, and white Caucasian patients, and was lower than in East Asia.

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U2 - 10.1007/s10147-012-0515-4

DO - 10.1007/s10147-012-0515-4

M3 - Article

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JO - International Journal of Clinical Oncology

JF - International Journal of Clinical Oncology

SN - 1341-9625

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ER -