Frequency of epidermal growth factor receptor mutations in Bangladeshi patients with adenocarcinoma of the lung

Shakibur Rahman, Nobuyuki Kondo, Kazue Yoneda, Teruhisa Takuwa, Masaki Hashimoto, Hayato Orui, Yoshitomo Okumura, Fumihiro Tanaka, Kanako Kumamoto, Mohammad Golam Mostafa, Golam Mohiuddin Akbar Chowdhury, Akramul Haque, Seiki Hasegawa

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Abstract

Background: Worldwide studies on lung adenocarcinoma have demonstrated a genetic divergence of the epidermal growth factor receptor (EGFR) pathway according to ethnicity, such as higher frequency of activated EGFR mutations among East Asian patients. However, such information is still lacking in some developing countries. Methods: We investigated the frequency of EGFR mutations among Bangladeshi patients with adenocarcinoma of the lung. Fine-needle aspiration tissue samples were collected from 61 Bangladeshi patients. Polymerase chain reaction-single-strand conformation polymorphism was performed on extracted DNA for mutational analysis of EGFR exons 19 and 21. Results: EGFR mutations were found in 14 of 61 (23.0 %) Bangladeshi patients. There was no significant difference in EGFR mutation rate with regard to patient's age, sex, smoking history, clinical stage of lung cancer, subtypes of adenocarcinoma, and tumor differentiation. Conclusion: The present study revealed that the EGFR mutation rate in Bangladeshi patients with adenocarcinoma of the lung was higher than in African-American, Arabian, and white Caucasian patients, and was lower than in East Asia.

Original languageEnglish
Pages (from-to)45-49
Number of pages5
JournalInternational Journal of Clinical Oncology
Volume19
Issue number1
DOIs
Publication statusPublished - 01-02-2014

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All Science Journal Classification (ASJC) codes

  • Surgery
  • Hematology
  • Oncology

Cite this

Rahman, S., Kondo, N., Yoneda, K., Takuwa, T., Hashimoto, M., Orui, H., Okumura, Y., Tanaka, F., Kumamoto, K., Mostafa, M. G., Chowdhury, G. M. A., Haque, A., & Hasegawa, S. (2014). Frequency of epidermal growth factor receptor mutations in Bangladeshi patients with adenocarcinoma of the lung. International Journal of Clinical Oncology, 19(1), 45-49. https://doi.org/10.1007/s10147-012-0515-4