Frequent loss of heterozygosity at telomeric loci on 22q in sporadic colorectal cancers

Ikuo Yana, Hiroki Kurahashi, Shoji Nakamori, Masao Kameyama, Tsutomu Nakamura, Motohisa Takami, Takesada Mori, Shinichiro Takai, Isamu Nishisho

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Abstract

To date, several tumor‐suppressor genes responsible for the tumorigenesis of colorectal cancer have been identified. However, studies of loss of heterozygosity (LOH) have suggested several chromosomal regions which may contain additional tumor‐suppressor genes for colorectal cancer. To determine the extent and variation of allelic loss on 22q, on which LOH has been frequently observed, a total of 68 sporadic colorectal cancers was examined for LOH on the chromosome arm by means of 16 polymorphic DNA markers. LOH was observed in 28 tumors (41 %), of which 9 showed LOH at all informative loci. The remaining 19 tumors showed variable patterns of partial loss on 22q, delimiting the smallest region of overlap (SRO) between D22S90 and D22S94. Moreover, LOH within the SRO correlated with a progression in terms of Dukes' stages. These results suggest that an additional tumor‐suppressor gene for colorectal cancer may exist on 22q distally to the NF2 locus and that inactivation of the gene may possibly play a role in the progression or metastasis of colorectal cancers. © 1995 Wiley‐Liss, Inc.

Original languageEnglish
Pages (from-to)174-177
Number of pages4
JournalInternational Journal of Cancer
Volume60
Issue number2
DOIs
Publication statusPublished - 01-01-1995
Externally publishedYes

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Loss of Heterozygosity
Colorectal Neoplasms
Genes
Gene Silencing
Genetic Markers
Neoplasms
Carcinogenesis
Chromosomes
Neoplasm Metastasis

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Yana, Ikuo ; Kurahashi, Hiroki ; Nakamori, Shoji ; Kameyama, Masao ; Nakamura, Tsutomu ; Takami, Motohisa ; Mori, Takesada ; Takai, Shinichiro ; Nishisho, Isamu. / Frequent loss of heterozygosity at telomeric loci on 22q in sporadic colorectal cancers. In: International Journal of Cancer. 1995 ; Vol. 60, No. 2. pp. 174-177.
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abstract = "To date, several tumor‐suppressor genes responsible for the tumorigenesis of colorectal cancer have been identified. However, studies of loss of heterozygosity (LOH) have suggested several chromosomal regions which may contain additional tumor‐suppressor genes for colorectal cancer. To determine the extent and variation of allelic loss on 22q, on which LOH has been frequently observed, a total of 68 sporadic colorectal cancers was examined for LOH on the chromosome arm by means of 16 polymorphic DNA markers. LOH was observed in 28 tumors (41 {\%}), of which 9 showed LOH at all informative loci. The remaining 19 tumors showed variable patterns of partial loss on 22q, delimiting the smallest region of overlap (SRO) between D22S90 and D22S94. Moreover, LOH within the SRO correlated with a progression in terms of Dukes' stages. These results suggest that an additional tumor‐suppressor gene for colorectal cancer may exist on 22q distally to the NF2 locus and that inactivation of the gene may possibly play a role in the progression or metastasis of colorectal cancers. {\circledC} 1995 Wiley‐Liss, Inc.",
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Yana, I, Kurahashi, H, Nakamori, S, Kameyama, M, Nakamura, T, Takami, M, Mori, T, Takai, S & Nishisho, I 1995, 'Frequent loss of heterozygosity at telomeric loci on 22q in sporadic colorectal cancers', International Journal of Cancer, vol. 60, no. 2, pp. 174-177. https://doi.org/10.1002/ijc.2910600207

Frequent loss of heterozygosity at telomeric loci on 22q in sporadic colorectal cancers. / Yana, Ikuo; Kurahashi, Hiroki; Nakamori, Shoji; Kameyama, Masao; Nakamura, Tsutomu; Takami, Motohisa; Mori, Takesada; Takai, Shinichiro; Nishisho, Isamu.

In: International Journal of Cancer, Vol. 60, No. 2, 01.01.1995, p. 174-177.

Research output: Contribution to journalArticle

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AU - Kurahashi, Hiroki

AU - Nakamori, Shoji

AU - Kameyama, Masao

AU - Nakamura, Tsutomu

AU - Takami, Motohisa

AU - Mori, Takesada

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AU - Nishisho, Isamu

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N2 - To date, several tumor‐suppressor genes responsible for the tumorigenesis of colorectal cancer have been identified. However, studies of loss of heterozygosity (LOH) have suggested several chromosomal regions which may contain additional tumor‐suppressor genes for colorectal cancer. To determine the extent and variation of allelic loss on 22q, on which LOH has been frequently observed, a total of 68 sporadic colorectal cancers was examined for LOH on the chromosome arm by means of 16 polymorphic DNA markers. LOH was observed in 28 tumors (41 %), of which 9 showed LOH at all informative loci. The remaining 19 tumors showed variable patterns of partial loss on 22q, delimiting the smallest region of overlap (SRO) between D22S90 and D22S94. Moreover, LOH within the SRO correlated with a progression in terms of Dukes' stages. These results suggest that an additional tumor‐suppressor gene for colorectal cancer may exist on 22q distally to the NF2 locus and that inactivation of the gene may possibly play a role in the progression or metastasis of colorectal cancers. © 1995 Wiley‐Liss, Inc.

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