Fructose intake during gestation and lactation differentially affects the expression of hippocampal neurosteroidogenic enzymes in rat offspring

Genki Mizuno, Eiji Munetsuna, Hiroya Yamada, Yoshitaka Ando, Mirai Yamazaki, Yuri Murase, Kanako Kondo, Hiroaki Ishikawa, Ryoji Teradaira, Koji Suzuki, Koji Ohashi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Neurosteroids, steroidal hormones synthesized de novo from cholesterol within the brain, stimulate hippocampal functions such as neuron protection and synapse formation. Previously, we examined the effect of maternal fructose on the transcriptional regulation of neurosteroidogenic enzymes. We found that the mRNA expression level of the steroidogenic acute regulatory protein (StAR), peripheral benzodiazepine receptor (PBR), cytochrome P450(11β), 11β-hydroxysteroid dehydrogenase (HSD), and 17β-HSD was altered. However, we could not determine whether maternal fructose intake played a role in the gestation or lactation period because the dam rats were fed fructose solution during both periods. Thus, in this study, we analyzed the hippocampi of the offspring of dams fed fructose during the gestation or lactation period. Maternal fructose consumption during either the gestation or lactation period did not affect the mRNA levels of StAR, P450(17α), 11β-HSD-2, and 17β-HSD-1. PBR expression was down-regulated, even when rats consumed fructose during the lactation period only, while fructose consumption during gestation tended to activate the expression of P450(11β)-2. We found that maternal fructose intake during gestation and lactation differentially affected the expression of hippocampal neurosteroidogenic enzymes in the offspring.

Original languageEnglish
Pages (from-to)71-77
Number of pages7
JournalEndocrine Research
Volume42
Issue number1
DOIs
Publication statusPublished - 02-01-2017

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Fructose
Lactation
Pregnancy
Enzymes
Mothers
GABA-A Receptors
11-beta-Hydroxysteroid Dehydrogenases
Messenger RNA
Synapses
Cytochrome P-450 Enzyme System
Neurotransmitter Agents
Hippocampus
Cholesterol
Hormones
Brain
3(17)-hydroxysteroid dehydrogenase

All Science Journal Classification (ASJC) codes

  • Endocrinology

Cite this

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title = "Fructose intake during gestation and lactation differentially affects the expression of hippocampal neurosteroidogenic enzymes in rat offspring",
abstract = "Neurosteroids, steroidal hormones synthesized de novo from cholesterol within the brain, stimulate hippocampal functions such as neuron protection and synapse formation. Previously, we examined the effect of maternal fructose on the transcriptional regulation of neurosteroidogenic enzymes. We found that the mRNA expression level of the steroidogenic acute regulatory protein (StAR), peripheral benzodiazepine receptor (PBR), cytochrome P450(11β), 11β-hydroxysteroid dehydrogenase (HSD), and 17β-HSD was altered. However, we could not determine whether maternal fructose intake played a role in the gestation or lactation period because the dam rats were fed fructose solution during both periods. Thus, in this study, we analyzed the hippocampi of the offspring of dams fed fructose during the gestation or lactation period. Maternal fructose consumption during either the gestation or lactation period did not affect the mRNA levels of StAR, P450(17α), 11β-HSD-2, and 17β-HSD-1. PBR expression was down-regulated, even when rats consumed fructose during the lactation period only, while fructose consumption during gestation tended to activate the expression of P450(11β)-2. We found that maternal fructose intake during gestation and lactation differentially affected the expression of hippocampal neurosteroidogenic enzymes in the offspring.",
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Fructose intake during gestation and lactation differentially affects the expression of hippocampal neurosteroidogenic enzymes in rat offspring. / Mizuno, Genki; Munetsuna, Eiji; Yamada, Hiroya; Ando, Yoshitaka; Yamazaki, Mirai; Murase, Yuri; Kondo, Kanako; Ishikawa, Hiroaki; Teradaira, Ryoji; Suzuki, Koji; Ohashi, Koji.

In: Endocrine Research, Vol. 42, No. 1, 02.01.2017, p. 71-77.

Research output: Contribution to journalArticle

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AU - Mizuno, Genki

AU - Munetsuna, Eiji

AU - Yamada, Hiroya

AU - Ando, Yoshitaka

AU - Yamazaki, Mirai

AU - Murase, Yuri

AU - Kondo, Kanako

AU - Ishikawa, Hiroaki

AU - Teradaira, Ryoji

AU - Suzuki, Koji

AU - Ohashi, Koji

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