Fulminant group A streptococcal infection without gangrene in the extremities: Analysis of five autopsy cases

Shu Kato, Motoi Yanazaki, Kino Hayashi, Fumiko Satoh, Ichiro Isobe, Yutaka Tsutsumi

Research output: Contribution to journalArticle

Abstract

Five autopsy cases of fulminant group A streptococcal infection without gangrene in the extremities are presented. Clinical course of the fulminant illness was short (2–4 days). One pathological autopsy case was aged (86-years-old), and hemorrhagic cystitis was observed. The other four forensic autopsy cases were young (24–38 years-old) with the mean age of 32, and the primary infective lesions were located in the postpartum endometrium, tonsil and bronchus (2 cases). Systemic coccal dissemination with poor neutrophilic reaction was seen in two of five cases. Bilateral renal cortical necrosis was noted in three cases (including two with bacterial embolism). Hemophagocytosis, probably resulting from hypercytokinemia, was characteristic in three cases without bacterial embolism. Gram-positive cocci colonizing the hemorrhagic and necrotizing lesions were consistently immunoreactive for streptococcal antigens and Strep A (a carbohydrate antigen on group A streptococci). Neutrophilic reaction was mild in the primary infected foci. Clinicians should note that fulminant streptococcal infection (streptococcal toxic shock syndrome) in young and immunocompetent patients may not be associated with gangrene in the extremities. Autopsy prosecutors (diagnostic and forensic pathologists) must recognize the difficulty in making an appropriate autopsy diagnosis, particularly when bacterial embolism is not associated.

Original languageEnglish
Pages (from-to)419-424
Number of pages6
JournalPathology International
Volume68
Issue number7
DOIs
Publication statusPublished - 07-2018

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Fingerprint Dive into the research topics of 'Fulminant group A streptococcal infection without gangrene in the extremities: Analysis of five autopsy cases'. Together they form a unique fingerprint.

  • Cite this