Fulminant Hepatitis in Primary Human Herpesvirus-6 Infection

Ryo Sobue, Hitoshi Miyazaki, Masataka Okamoto, Masami Hirano, Tetsushi Yoshikawa, Sadao Suga, Yoshizo Asano

Research output: Contribution to journalLetter

60 Citations (Scopus)

Abstract

To the Editor: Liver damage in primary human herpesvirus-6 infection has been reported in infants1,2 and adults.3 4 5 All patients had a benign, self-limited course except one infant with fatal fulminant hepatitis.1 We describe here an adult with fulminant hepatitis associated with lymphadenopathy and marked atypical lymphocytosis presumably caused by herpesvirus-6 infection. A 29-year-old man was admitted to our hospital on October 17, 1989, with fever, jaundice, skin rash, and lymphadenopathy, which had developed 10 days earlier. The bilirubin concentration (2.4 mg per deciliter), aminotransferase activities, and prothrombin time (18 percent) confirmed hepatic involvement. Generalized lymphadenopathy with leukocytosis (33,100 per.

Original languageEnglish
Number of pages1
JournalNew England Journal of Medicine
Volume324
Issue number18
DOIs
Publication statusPublished - 02-05-1991

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Human Herpesvirus 6
Herpesviridae Infections
Hepatitis
Lymphocytosis
Liver
Prothrombin Time
Leukocytosis
Transaminases
Jaundice
Exanthema
Bilirubin
Fever
Lymphadenopathy

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Sobue, Ryo ; Miyazaki, Hitoshi ; Okamoto, Masataka ; Hirano, Masami ; Yoshikawa, Tetsushi ; Suga, Sadao ; Asano, Yoshizo. / Fulminant Hepatitis in Primary Human Herpesvirus-6 Infection. In: New England Journal of Medicine. 1991 ; Vol. 324, No. 18.
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Fulminant Hepatitis in Primary Human Herpesvirus-6 Infection. / Sobue, Ryo; Miyazaki, Hitoshi; Okamoto, Masataka; Hirano, Masami; Yoshikawa, Tetsushi; Suga, Sadao; Asano, Yoshizo.

In: New England Journal of Medicine, Vol. 324, No. 18, 02.05.1991.

Research output: Contribution to journalLetter

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T1 - Fulminant Hepatitis in Primary Human Herpesvirus-6 Infection

AU - Sobue, Ryo

AU - Miyazaki, Hitoshi

AU - Okamoto, Masataka

AU - Hirano, Masami

AU - Yoshikawa, Tetsushi

AU - Suga, Sadao

AU - Asano, Yoshizo

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AB - To the Editor: Liver damage in primary human herpesvirus-6 infection has been reported in infants1,2 and adults.3 4 5 All patients had a benign, self-limited course except one infant with fatal fulminant hepatitis.1 We describe here an adult with fulminant hepatitis associated with lymphadenopathy and marked atypical lymphocytosis presumably caused by herpesvirus-6 infection. A 29-year-old man was admitted to our hospital on October 17, 1989, with fever, jaundice, skin rash, and lymphadenopathy, which had developed 10 days earlier. The bilirubin concentration (2.4 mg per deciliter), aminotransferase activities, and prothrombin time (18 percent) confirmed hepatic involvement. Generalized lymphadenopathy with leukocytosis (33,100 per.

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