Fulminant Hepatitis in Primary Human Herpesvirus-6 Infection

Ryo Sobue; Hitoshi Miyazaki; Masataka Okamoto; Masami Hirano; Tetsushi Yoshikawa; Sadao Suga; Yoshizo Asano

doi:10.1056/NEJM199105023241818

Fulminant Hepatitis in Primary Human Herpesvirus-6 Infection

Ryo Sobue
, Hitoshi Miyazaki
, Masataka Okamoto
, Masami Hirano
, Tetsushi Yoshikawa
, Sadao Suga
, Yoshizo Asano

Research output: Contribution to journal › Letter › peer-review

65 Citations (Scopus)

Abstract

To the Editor: Liver damage in primary human herpesvirus-6 infection has been reported in infants¹^,² and adults.³ ⁴ ⁵ All patients had a benign, self-limited course except one infant with fatal fulminant hepatitis.¹ We describe here an adult with fulminant hepatitis associated with lymphadenopathy and marked atypical lymphocytosis presumably caused by herpesvirus-6 infection. A 29-year-old man was admitted to our hospital on October 17, 1989, with fever, jaundice, skin rash, and lymphadenopathy, which had developed 10 days earlier. The bilirubin concentration (2.4 mg per deciliter), aminotransferase activities, and prothrombin time (18 percent) confirmed hepatic involvement. Generalized lymphadenopathy with leukocytosis (33,100 per.

Original language	English
Pages (from-to)	1290
Number of pages	1
Journal	New England Journal of Medicine
Volume	324
Issue number	18
DOIs	https://doi.org/10.1056/NEJM199105023241818
Publication status	Published - 02-05-1991
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

General Medicine

Access to Document

10.1056/NEJM199105023241818

Cite this

@article{9487d95b076b43ada86c344ee4d3c31c,

title = "Fulminant Hepatitis in Primary Human Herpesvirus-6 Infection",

abstract = "To the Editor: Liver damage in primary human herpesvirus-6 infection has been reported in infants1,2 and adults.3 4 5 All patients had a benign, self-limited course except one infant with fatal fulminant hepatitis.1 We describe here an adult with fulminant hepatitis associated with lymphadenopathy and marked atypical lymphocytosis presumably caused by herpesvirus-6 infection. A 29-year-old man was admitted to our hospital on October 17, 1989, with fever, jaundice, skin rash, and lymphadenopathy, which had developed 10 days earlier. The bilirubin concentration (2.4 mg per deciliter), aminotransferase activities, and prothrombin time (18 percent) confirmed hepatic involvement. Generalized lymphadenopathy with leukocytosis (33,100 per.",

author = "Ryo Sobue and Hitoshi Miyazaki and Masataka Okamoto and Masami Hirano and Tetsushi Yoshikawa and Sadao Suga and Yoshizo Asano",

year = "1991",

month = may,

day = "2",

doi = "10.1056/NEJM199105023241818",

language = "English",

volume = "324",

pages = "1290",

journal = "New England Journal of Medicine",

issn = "0028-4793",

publisher = "Massachussetts Medical Society",

number = "18",

}

TY - JOUR

T1 - Fulminant Hepatitis in Primary Human Herpesvirus-6 Infection

AU - Sobue, Ryo

AU - Miyazaki, Hitoshi

AU - Okamoto, Masataka

AU - Hirano, Masami

AU - Yoshikawa, Tetsushi

AU - Suga, Sadao

AU - Asano, Yoshizo

PY - 1991/5/2

Y1 - 1991/5/2

N2 - To the Editor: Liver damage in primary human herpesvirus-6 infection has been reported in infants1,2 and adults.3 4 5 All patients had a benign, self-limited course except one infant with fatal fulminant hepatitis.1 We describe here an adult with fulminant hepatitis associated with lymphadenopathy and marked atypical lymphocytosis presumably caused by herpesvirus-6 infection. A 29-year-old man was admitted to our hospital on October 17, 1989, with fever, jaundice, skin rash, and lymphadenopathy, which had developed 10 days earlier. The bilirubin concentration (2.4 mg per deciliter), aminotransferase activities, and prothrombin time (18 percent) confirmed hepatic involvement. Generalized lymphadenopathy with leukocytosis (33,100 per.

AB - To the Editor: Liver damage in primary human herpesvirus-6 infection has been reported in infants1,2 and adults.3 4 5 All patients had a benign, self-limited course except one infant with fatal fulminant hepatitis.1 We describe here an adult with fulminant hepatitis associated with lymphadenopathy and marked atypical lymphocytosis presumably caused by herpesvirus-6 infection. A 29-year-old man was admitted to our hospital on October 17, 1989, with fever, jaundice, skin rash, and lymphadenopathy, which had developed 10 days earlier. The bilirubin concentration (2.4 mg per deciliter), aminotransferase activities, and prothrombin time (18 percent) confirmed hepatic involvement. Generalized lymphadenopathy with leukocytosis (33,100 per.

UR - https://www.scopus.com/pages/publications/0025819422

UR - https://www.scopus.com/pages/publications/0025819422#tab=citedBy

U2 - 10.1056/NEJM199105023241818

DO - 10.1056/NEJM199105023241818

M3 - Letter

C2 - 1849614

AN - SCOPUS:0025819422

SN - 0028-4793

VL - 324

SP - 1290

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 18

ER -

Fulminant Hepatitis in Primary Human Herpesvirus-6 Infection

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this