Function of a cell adhesion molecule, plexin, in neuron network formation

Hajime Fujisawa, Kunimasa Ohta, Toshiki Kameyama, Yasunori Murakami

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


Plexin is a type I membrane protein which was identified in Xenopus nervous system by hybridoma technique. Molecular cloning studies demonstrated that the extracellular segment of the plexin protein possesses three internal repeats of cysteine cluster which are homologous to the cysteine-rich domain of the omet proto-oncogene protein product. A cell aggregation test revealed that the plexin protein mediated cell adhesion via a homophilic binding mechanism, in the presence of calcium ions. Plexin was expressed in the neuronal elements composing particular neuron circuits in Xenopus CNS and PNS. These findings indicate that plexin is a new member of the Ca2+-dependent cell adhesion molecules, and suggest that the molecule plays an important role in neuronal cell contact and neuron network formation.

Original languageEnglish
Pages (from-to)101-105
Number of pages5
JournalDevelopmental Neuroscience
Issue number1
Publication statusPublished - 1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neurology
  • Developmental Neuroscience


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