Function of a cell adhesion molecule, plexin, in neuron network formation

Hajime Fujisawa, Kunimasa Ohta, Toshiki Kameyama, Yasunori Murakami

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Plexin is a type I membrane protein which was identified in Xenopus nervous system by hybridoma technique. Molecular cloning studies demonstrated that the extracellular segment of the plexin protein possesses three internal repeats of cysteine cluster which are homologous to the cysteine-rich domain of the omet proto-oncogene protein product. A cell aggregation test revealed that the plexin protein mediated cell adhesion via a homophilic binding mechanism, in the presence of calcium ions. Plexin was expressed in the neuronal elements composing particular neuron circuits in Xenopus CNS and PNS. These findings indicate that plexin is a new member of the Ca2+-dependent cell adhesion molecules, and suggest that the molecule plays an important role in neuronal cell contact and neuron network formation.

Original languageEnglish
Pages (from-to)101-105
Number of pages5
JournalDevelopmental Neuroscience
Volume19
Issue number1
DOIs
Publication statusPublished - 01-01-1997

Fingerprint

Cell Adhesion Molecules
Neurons
Xenopus
Cysteine
Proto-Oncogene Proteins
Cell Aggregation
Oncogene Proteins
Hybridomas
Molecular Cloning
Cell Adhesion
Nervous System
Membrane Proteins
Proteins
plexin
Ions
Calcium

All Science Journal Classification (ASJC) codes

  • Neurology
  • Developmental Neuroscience

Cite this

Fujisawa, Hajime ; Ohta, Kunimasa ; Kameyama, Toshiki ; Murakami, Yasunori. / Function of a cell adhesion molecule, plexin, in neuron network formation. In: Developmental Neuroscience. 1997 ; Vol. 19, No. 1. pp. 101-105.
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Function of a cell adhesion molecule, plexin, in neuron network formation. / Fujisawa, Hajime; Ohta, Kunimasa; Kameyama, Toshiki; Murakami, Yasunori.

In: Developmental Neuroscience, Vol. 19, No. 1, 01.01.1997, p. 101-105.

Research output: Contribution to journalArticle

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